Gene Review:
Casp2 - caspase 2
Rattus norvegicus
Synonyms:
CASP-2, Caspase-2, Ich1, Protease ICH-1
- Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. Jin, K., Nagayama, T., Mao, X., Kawaguchi, K., Hickey, R.W., Greenberg, D.A., Simon, R.P., Graham, S.H. J. Neurochem. (2002)
- Cloning and expression of the cDNA encoding rat caspase-2. Sato, N., Milligan, C.E., Uchiyama, Y., Oppenheim, R.W. Gene (1997)
- Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. Singh, M., Savitz, S.I., Hoque, R., Gupta, G., Roth, S., Rosenbaum, P.S., Rosenbaum, D.M. J. Neurochem. (2001)
- Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD). Tao, Y., Kim, J., Stanley, M., He, Z., Faubel, S., Schrier, R.W., Edelstein, C.L. Kidney Int. (2005)
- Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Shimohama, S., Tanino, H., Fujimoto, S. Biochem. Biophys. Res. Commun. (1999)
- Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. Vaudry, D., Rousselle, C., Basille, M., Falluel-Morel, A., Pamantung, T.F., Fontaine, M., Fournier, A., Vaudry, H., Gonzalez, B.J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal. Wang, Q., Maniati, M., Jabado, O., Pavlaki, M., Troy, C.M., Greene, L.A., Stefanis, L. Cell Death Differ. (2006)
- RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons. Jabado, O., Wang, Q., Rideout, H.J., Yeasmin, M., Guo, K.X., Vekrellis, K., Papantonis, S., Angelastro, J.M., Troy, C.M., Stefanis, L. Cell Death Differ. (2004)
- A serine protease is involved in the initiation of DNA damage-induced apoptosis. de Bruin, E.C., Meersma, D., de Wilde, J., den Otter, I., Schipper, E.M., Medema, J.P., Peltenburg, L.T. Cell Death Differ. (2003)
- Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways. Fu, Y.C., Chi, C.S., Yin, S.C., Hwang, B., Chiu, Y.T., Hsu, S.L. Cardiovasc. Res. (2004)
- The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells. Haviv, R., Stein, R. J. Neurosci. Res. (1998)
- Caspaselike proteases activated in apoptotic photoreceptors of Royal College of Surgeons rats. Katai, N., Kikuchi, T., Shibuki, H., Kuroiwa, S., Arai, J., Kurokawa, T., Yoshimura, N. Invest. Ophthalmol. Vis. Sci. (1999)
- Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32). Suzuki, Y., Farbman, A.I. Exp. Neurol. (2000)
- Differential c-Fos and caspase expression following kainic acid excitotoxicity. Ferrer, I., López, E., Blanco, R., Rivera, R., Krupinski, J., Martí, E. Acta Neuropathol. (2000)
- B cell apoptosis triggered by antigen receptor ligation proceeds via a novel caspase-dependent pathway. Chen, W., Wang, H.G., Srinivasula, S.M., Alnemri, E.S., Cooper, N.R. J. Immunol. (1999)
- Caspase inhibition decreases cell death in regions of adult neurogenesis. Biebl, M., Winner, B., Winkler, J. Neuroreport (2005)
- Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. Stefanis, L., Troy, C.M., Qi, H., Shelanski, M.L., Greene, L.A. J. Neurosci. (1998)
- Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Schulz, J.B., Weller, M., Matthews, R.T., Heneka, M.T., Groscurth, P., Martinou, J.C., Lommatzsch, J., von Coelln, R., Wüllner, U., Löschmann, P.A., Beal, M.F., Dichgans, J., Klockgether, T. Cell Death Differ. (1998)
- ICE-like protease (caspase) is involved in transforming growth factor beta1-mediated apoptosis in FaO rat hepatoma cell line. Choi, K.S., Lim, I.K., Brady, J.N., Kim, S.J. Hepatology (1998)
- Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Flaws, J.A., Kugu, K., Trbovich, A.M., DeSanti, A., Tilly, K.I., Hirshfield, A.N., Tilly, J.L. Endocrinology (1995)
- Caspase activation pathways induced by staurosporine and low potassium: role of caspase-2. Caballero-Benítez, A., Morán, J. J. Neurosci. Res. (2003)
- Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. Marques, C.A., Keil, U., Bonert, A., Steiner, B., Haass, C., Muller, W.E., Eckert, A. J. Biol. Chem. (2003)
- Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia. Hornum, L., Rasmussen, S.B., Markholst, H. Mamm. Genome (1999)
- Gene expression analysis of the rat testis after treatment with di(2-ethylhexyl) phthalate using cDNA microarray and real-time RT-PCR. Kijima, K., Toyosawa, K., Yasuba, M., Matsuoka, N., Adachi, T., Komiyama, M., Mori, C. Toxicol. Appl. Pharmacol. (2004)
- Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats. Kitagawa, H., Hayashi, T., Mitsumoto, Y., Koga, N., Itoyama, Y., Abe, K. Stroke (1998)
- Caspase-2 activation is redundant during seizure-induced neuronal death. Henshall, D.C., Skradski, S.L., Bonislawski, D.P., Lan, J.Q., Simon, R.P. J. Neurochem. (2001)
- BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. Kurokawa, T., Katai, N., Shibuki, H., Kuroiwa, S., Kurimoto, Y., Nakayama, C., Yoshimura, N. Invest. Ophthalmol. Vis. Sci. (1999)