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Gene Review

Rbp1  -  retinol binding protein 1, cellular

Rattus norvegicus

Synonyms: CRBP, CRBP-I, Cellular retinol-binding protein, Cellular retinol-binding protein I, Rbp-1, ...
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Disease relevance of Rbp1


High impact information on Rbp1


Chemical compound and disease context of Rbp1


Biological context of Rbp1


Anatomical context of Rbp1


Associations of Rbp1 with chemical compounds

  • Thus binding of retinol markedly reduced conformational flexibility in both CRBP I and CRBP II on the micro- to millisecond timescale [11].
  • Intraligand NOE cross-peaks were detected for the hydroxyl proton in the NOESY spectrum of CRBP I-bound retinol, but not for CRBP II-bound retinol, indicating that the conformational dynamics of retinol binding are different for these two proteins [11].
  • Finally, when retinol-deficient rats are fed retinyl acetate for 4 hr, about 4-fold accumulation of CRBP-specific mRNA is observed in the lungs [8].
  • The primary structure of rat liver CRBP was elucidated by analyses of cyanogen bromide fragments and peptides obtained by tryptic and thermolytic digestions [19].
  • Both polypeptides contain reactive thiol groups, but the rate of disruption of CRBP II-retinol complexes by p-chloromercuribenzoate is greater than that of CRBP-retinol [20].

Physical interactions of Rbp1


Other interactions of Rbp1


Analytical, diagnostic and therapeutic context of Rbp1


  1. Characterization of rat cellular retinol-binding protein II expressed in Escherichia coli. Li, E., Locke, B., Yang, N.C., Ong, D.E., Gordon, J.I. J. Biol. Chem. (1987) [Pubmed]
  2. Cellular binding proteins for vitamin A in colorectal adenocarcinoma of rat. Ong, D.E., Markert, C., Chiu, J.F. Cancer Res. (1978) [Pubmed]
  3. Cytoplasmic retinoid-binding proteins and retinoid effects on insulin release in RINm5F beta-cells. Chertow, B.S., Moore, M.R., Blaner, W.S., Wilford, M.R., Cordle, M.B. Diabetes (1989) [Pubmed]
  4. Expression of cellular retinol- and cellular retinoic acid-binding proteins in the rat cervical epithelium is regulated by endocrine stimuli during normal squamous metaplasia. Tannous-Khuri, L., Hillemanns, P., Rajan, N., Wright, T.C., Talmage, D.A. Am. J. Pathol. (1994) [Pubmed]
  5. Specificity of cellular retinol-binding protein for compounds with vitamin A activity. Ong, D.E., Chytil, F. Nature (1975) [Pubmed]
  6. Interaction of the retinol/cellular retinol-binding protein complex with isolated nuclei and nuclear components. Liau, G., Ong, D.E., Chytil, F. J. Cell Biol. (1981) [Pubmed]
  7. Localization of cellular retinol-binding protein and retinol-binding protein in cells comprising the blood-brain barrier of rat and human. MacDonald, P.N., Bok, D., Ong, D.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. Sherman, D.R., Lloyd, R.S., Chytil, F. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  9. Nuclear magnetic resonance studies of 6-fluorotryptophan-substituted rat cellular retinol-binding protein II produced in Escherichia coli. Analysis of the apoprotein and the holoprotein containing bound all-trans-retinol and all-trans-retinal. Li, E., Quian, S.J., Nader, L., Yang, N.C., d'Avignon, A., Sacchettini, J.C., Gordon, J.I. J. Biol. Chem. (1989) [Pubmed]
  10. 19F nuclear magnetic resonance studies of 6-fluorotryptophan-substituted rat cellular retinol binding protein II produced in Escherichia coli. An analysis of four tryptophan substitution mutants and their interactions with all-trans-retinol. Li, E., Qian, S.J., Yang, N.C., d'Avignon, A., Gordon, J.I. J. Biol. Chem. (1990) [Pubmed]
  11. Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility. Lu, J., Cistola, D.P., Li, E. J. Mol. Biol. (2003) [Pubmed]
  12. Fluorine nuclear magnetic resonance analysis of the ligand binding properties of two homologous rat cellular retinol-binding proteins expressed in Escherichia coli. Li, E., Qian, S.J., Winter, N.S., d'Avignon, A., Levin, M.S., Gordon, J.I. J. Biol. Chem. (1991) [Pubmed]
  13. Gene expression of retinoic acid receptors, retinoid-X receptors, and cellular retinol-binding protein I in bone and its regulation by vitamin A. Harada, H., Miki, R., Masushige, S., Kato, S. Endocrinology (1995) [Pubmed]
  14. NMR studies of fluororetinol analogs complexed to two homologous rat cellular retinol-binding proteins. Rong, D., Lovey, A.J., Rosenberger, M., d'Avignon, D.A., Li, E. Biochim. Biophys. Acta (1994) [Pubmed]
  15. Cellular retinol-binding protein. Quantitation and distribution. Eriksson, U., Das, K., Busch, C., Nordlinder, H., Rask, L., Sundelin, J., Sällström, J., Peterson, P.A. J. Biol. Chem. (1984) [Pubmed]
  16. Interactions of retinol with binding proteins: studies with rat cellular retinol-binding protein and with rat retinol-binding protein. Noy, N., Blaner, W.S. Biochemistry (1991) [Pubmed]
  17. Unsaturated fatty acids regulate gene expression of cellular retinol-binding protein, type II in rat jejunum. Suruga, K., Suzuki, R., Goda, T., Takase, S. J. Nutr. (1995) [Pubmed]
  18. Transcriptional regulation of cellular retinol-binding protein, type II gene expression in small intestine by dietary fat. Suruga, K., Mochizuki, K., Kitagawa, M., Goda, T., Horie, N., Takeishi, K., Takase, S. Arch. Biochem. Biophys. (1999) [Pubmed]
  19. The primary structure of rat liver cellular retinol-binding protein. Sundelin, J., Anundi, H., Trägårdh, L., Eriksson, U., Lind, P., Ronne, H., Peterson, P.A., Rask, L. J. Biol. Chem. (1985) [Pubmed]
  20. Rat cellular retinol-binding protein II: use of a cloned cDNA to define its primary structure, tissue-specific expression, and developmental regulation. Li, E., Demmer, L.A., Sweetser, D.A., Ong, D.E., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  21. Cellular retinol-binding protein and retinoic acid-binding protein in rat testes: effect of retinol depletion. Ong, D.E., Tsai, C.H., Chytil, F. J. Nutr. (1976) [Pubmed]
  22. Retinyl methyl ether: binding to transport proteins and effect on transcriptional regulation. Sani, B.P., Zhang, X., Hill, D.L., Shealy, Y.F. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  23. Modulation of the expression of peroxisome proliferator-activated receptor-dependent genes through disproportional expression of two subtypes in the small intestine. Mochizuki, K., Suruga, K., Kitagawa, M., Takase, S., Goda, T. Arch. Biochem. Biophys. (2001) [Pubmed]
  24. Rat liver cytosolic retinal dehydrogenase: comparison of 13-cis-, 9-cis-, and all-trans-retinal as substrates and effects of cellular retinoid-binding proteins and retinoic acid on activity. el Akawi, Z., Napoli, J.L. Biochemistry (1994) [Pubmed]
  25. Alteration of the binding specificity of cellular retinol-binding protein II by site-directed mutagenesis. Cheng, L., Qian, S.J., Rothschild, C., d'Avignon, A., Lefkowith, J.B., Gordon, J.I., Li, E. J. Biol. Chem. (1991) [Pubmed]
  26. Crystallization of rat cellular retinol binding protein II. Preliminary X-ray data obtained from the apoprotein expressed in Escherichia coli. Sacchettini, J.C., Stockhausen, D., Li, E., Banaszak, L.J., Gordon, J.I. J. Biol. Chem. (1987) [Pubmed]
  27. Regulation of cellular retinol binding protein type II by 1,25-dihydroxyvitamin D3. Finlay, J.A., Strom, M., Ong, D.E., DeLuca, H.F. Biochemistry (1990) [Pubmed]
  28. Retinoids and retinoid-binding protein expression in rat adipocytes. Tsutsumi, C., Okuno, M., Tannous, L., Piantedosi, R., Allan, M., Goodman, D.S., Blaner, W.S. J. Biol. Chem. (1992) [Pubmed]
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