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Gene Review

Fabp6  -  fatty acid binding protein 6, ileal...

Mus musculus

Synonyms: Fatty acid-binding protein 6, GT, Gastrotropin, I-15P, I-BABP, ...
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Disease relevance of Fabp6

  • To explore a possible cause for this gender dimorphic effect, we examined the changes in expression of genes that encode liver fatty acid binding protein (L-FABP) and ileal lipid binding protein in the small intestine resulting from I-FABP deficiency [1].
  • In two of five families, kidney lesions consisting of proximal tubular hyperplasia, renal cysts, and microadenomas developed in male animals; males also expressed higher levels of gamma GT/rasT24 RNA [2].
  • Thus, the Spnr(GT/GT) mutant male mouse provides a unique model for some human male infertility cases [3].
  • Adenoviral vector-mediated transfer of pig alpha(1, 3) GT gene into human tumor cells such as malignant melanoma A375, stomach cancer SGC-7901, and lung cancer SPC-A-1 was reported for the first time [4].
  • In a previous work, our group reported that Albino Swiss male mice inoculated with T. cruzi to develop acute lethal infection by day 15 decreased parasitemia and survived when treated with total brain gangliosides (GT; 1 mg, daily) [5].

High impact information on Fabp6

  • Normal, chimeric-transgenic, and transgenic mice have been used to study the axial patterns of ileal lipid-binding protein gene (Ilbp) expression during and after completion of gut morphogenesis [6].
  • Ilbp is initially activated in enterocytes in bidirectional wave that expands proximally in the ileum and distally to the colon during late gestation and the first postnatal week [6].
  • Although the heterogeneity of the 5' ends of gamma GT RNAs may be explained in part by alternative splicing, it is likely that multiple promoters are involved in their generation [7].
  • One of these genes appears to be deleted in individuals lacking GT activity on trans-stilbene oxide [8].
  • Although all the RNA samples examined contained class-alpha GT mRNA, class-mu GT mRNA was found only in individuals whose peripheral leukocytes expressed GT activity on the substrate trans-stilbene oxide [8].

Biological context of Fabp6


Anatomical context of Fabp6

  • I-BABP mRNA levels were significatively increased when the human enterocyte-like CaCo-2 cells were CS-deprived and repressed when CS were added to the medium [9].
  • The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors [12].
  • The ileal lipid-binding protein (ILBP) is the only physiologically relevant bile acid-binding protein in the cytosol of ileocytes [13].
  • The results indicate that both L-FABP and ilbp levels are modestly increased in the small intestine of chow-fed mice lacking I-FABP [1].
  • To elucidate the mechanisms that generate these different mRNAs we determined the transcription start sites of gamma GT kidney mRNAs and investigated the ability of the 5'-flanking regions of mRNAs I, II, IV, V, and VI to direct transcription of chloramphenicol acetyltransferase (CAT) reporter gene constructs in a mouse kidney cell line [14].

Associations of Fabp6 with chemical compounds

  • A highly conserved sterol regularory element-like sequence (SRE) and a putative GC box were found in human I-BABP gene promoter [9].
  • Indeed, treatment with the PPARalpha-PPARbeta/delta agonist bezafibrate led to the up-regulation of I-BABP mRNA levels in the human intestine-derived Caco-2 cells [12].
  • By chemical modification and NMR structure of ILBP, arginine residue 122 was identified as the probable contact point for the negatively charged side chain of cholyltaurine [13].
  • Consequently, bile acids bind to ILBP with the steroid nucleus deep inside the protein cavity and the negatively charged side chain near the entry portal [13].
  • The effect of Glc deprivation (starvation) on hexose transporter (GT) polypeptide(s) (pp) was studied in 3T3-C2 murine fibroblasts [15].

Other interactions of Fabp6


Analytical, diagnostic and therapeutic context of Fabp6


  1. Adaptations to the loss of intestinal fatty acid binding protein in mice. Agellon, L.B., Li, L., Luong, L., Uwiera, R.R. Mol. Cell. Biochem. (2006) [Pubmed]
  2. Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys. Schaffner, D.L., Barrios, R., Massey, C., Bañez, E.I., Ou, C.N., Rajagopalan, S., Aguilar-Cordova, E., Lebovitz, R.M., Overbeek, P.A., Lieberman, M.W. Am. J. Pathol. (1993) [Pubmed]
  3. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva, A., Nayernia, K., Engel, W., Torres, M., Stoykova, A., Chowdhury, K., Gruss, P. Dev. Biol. (2001) [Pubmed]
  4. Adenovirus-mediated expression of pig alpha(1, 3) galactosyltransferase reconstructs Gal alpha(1, 3) gal epitope on the surface of human tumor cells. Xing, L., Xia, G.H., Fei, J., Huang, F., Guo, L.H. Cell Res. (2001) [Pubmed]
  5. GM1 ganglioside induced myocardial restoration and survival of mice with experimental Chagas' disease. Cossy Isasi, S., Fernandez, A.R., Paglini, P., Bronia, D.H. Acta Trop. (1999) [Pubmed]
  6. The mouse ileal lipid-binding protein gene: a model for studying axial patterning during gut morphogenesis. Crossman, M.W., Hauft, S.M., Gordon, J.I. J. Cell Biol. (1994) [Pubmed]
  7. Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse. Rajagopalan, S., Wan, D.F., Habib, G.M., Sepulveda, A.R., McLeod, M.R., Lebovitz, R.M., Lieberman, M.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Seidegård, J., Vorachek, W.R., Pero, R.W., Pearson, W.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  9. Sterol regulatory element-binding protein-1c is responsible for cholesterol regulation of ileal bile acid-binding protein gene in vivo. Possible involvement of liver-X-receptor. Zaghini, I., Landrier, J.F., Grober, J., Krief, S., Jones, S.A., Monnot, M.C., Lefrere, I., Watson, M.A., Collins, J.L., Fujii, H., Besnard, P. J. Biol. Chem. (2002) [Pubmed]
  10. Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. Birkenmeier, E.H., Rowe, L.B., Crossman, M.W., Gordon, J.I. Mamm. Genome (1994) [Pubmed]
  11. The relative ligand binding preference of the murine ileal lipid binding protein. Labonté, E.D., Li, Q., Kay, C.M., Agellon, L.B. Protein Expr. Purif. (2003) [Pubmed]
  12. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. Landrier, J.F., Thomas, C., Grober, J., Zaghini, I., Petit, V., Poirier, H., Niot, I., Besnard, P. Biochim. Biophys. Acta (2005) [Pubmed]
  13. Identification of the bile acid-binding site of the ileal lipid-binding protein by photoaffinity labeling, matrix-assisted laser desorption ionization-mass spectrometry, and NMR structure. Kramer, W., Sauber, K., Baringhaus, K.H., Kurz, M., Stengelin, S., Lange, G., Corsiero, D., Girbig, F., König, W., Weyland, C. J. Biol. Chem. (2001) [Pubmed]
  14. The mouse gamma-glutamyl transpeptidase gene is transcribed from at least five separate promoters. Sepulveda, A.R., Carter, B.Z., Habib, G.M., Lebovitz, R.M., Lieberman, M.W. J. Biol. Chem. (1994) [Pubmed]
  15. Glucose deprivation and hexose transporter polypeptides of murine fibroblasts. Haspel, H.C., Wilk, E.W., Birnbaum, M.J., Cushman, S.W., Rosen, O.M. J. Biol. Chem. (1986) [Pubmed]
  16. Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor. Campana, G., Pasini, P., Roda, A., Spampinato, S. Biochem. Pharmacol. (2005) [Pubmed]
  17. Ontogenetic development and spatial distribution of the ileal apical sodium-dependent bile acid transporter and the ileal lipid-binding protein in apoE knockout and C57BL/6 mice. Håkansson, P., Andersson, I., Nyström, S., Löfgren, L., Amrot, L.F., Li, H. Scand. J. Gastroenterol. (2002) [Pubmed]
  18. Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells. Sepulveda, A.R., Habib, G.M., Damjanov, A., Matacic, S., Damjanov, I., Lebovitz, R.M., Lieberman, M.W. Exp. Cell Res. (1995) [Pubmed]
  19. Human xenoreactivity is reduced in mice bearing porcine antisense alpha(1,3) galactosyltransferase cDNA. Ma, Y.H., Zhou, X.G., Hu, J.H., Fei, J., Xia, G.H., Guo, L.H. Acta Pharmacol. Sin. (2001) [Pubmed]
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