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MeSH Review


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Disease relevance of Hypernatremia


Psychiatry related information on Hypernatremia


High impact information on Hypernatremia


Chemical compound and disease context of Hypernatremia


Biological context of Hypernatremia


Anatomical context of Hypernatremia


Gene context of Hypernatremia

  • Both the euthyroid and the hypothyroid animals receiving 2% NaCl developed hypernatremia and increased the levels and the size of OT and AVP mRNAs compared to their tap water cohorts [23].
  • GN and UGN therefore participate in the prevention of hypernatremia and hypervolemia after salty meals [24].
  • At the same time, we found that oxytocin (OT) receptors were important mediators of natriuresis induced by hypernatremia but not of that induced by isotonic volume expansion [25].
  • Patients who developed hypernatremia during hospitalization were younger than patients who developed hypernatremia before hospital admission (mean age +/- SD, 58.9 +/- 19.2 years compared with 76.6 +/- 16.6 years; P < 0.01) but did not differ in age from the patients of the general hospitalized population [26].
  • An infant with microcephaly and delayed development was found to have chronic asymptomatic hypernatremia [27].

Analytical, diagnostic and therapeutic context of Hypernatremia


  1. Hypernatremia and lactulose therapy. Nelson, D.C., McGrew, W.R., Hoyumpa, A.M. JAMA (1983) [Pubmed]
  2. Hemodynamic, ventilatory, and biochemical responses of panic patients and normal controls with sodium lactate infusion and spontaneous panic attacks. Gaffney, F.A., Fenton, B.J., Lane, L.D., Lake, C.R. Arch. Gen. Psychiatry (1988) [Pubmed]
  3. Direct suppressive effect of acute metabolic and respiratory alkalosis on parathyroid hormone secretion in the dog. Lopez, I., Rodriguez, M., Felsenfeld, A.J., Estepa, J.C., Aguilera-Tejero, E. J. Bone Miner. Res. (2003) [Pubmed]
  4. Selective osmoreceptor dysfunction presenting as intermittent hypernatremia following surgery for a pituitary chromophobe adenoma. Arem, R., Rushford, F.E., Segal, J., Robinson, A., Grossman, R.G., Field, J.B. Am. J. Med. (1986) [Pubmed]
  5. The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog. Düsing, R., Gill, J.R., Güllner, H.G., Bartter, F.C. Endocrinology (1982) [Pubmed]
  6. Sodium lactate and hypertonic sodium chloride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder. Peskind, E.R., Jensen, C.F., Pascualy, M., Tsuang, D., Cowley, D., Martin, D.C., Wilkinson, C.W., Raskind, M.A. Biol. Psychiatry (1998) [Pubmed]
  7. Central diabetes insipidus following intracranial hemorrhage due to vitamin K deficiency in a neonate. Caksen, H., Odabaş, D., Kaya, A., Cesur, Y., Kiymaz, N., Etlik, O., Turhan, S. Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi. (2005) [Pubmed]
  8. Hypodipsic hypernatremia with normal osmoregulation of vasopressin. Hammond, D.N., Moll, G.W., Robertson, G.L., Chelmicka-Schorr, E. N. Engl. J. Med. (1986) [Pubmed]
  9. Taurine: possible role in osmotic regulation of mammalian heart. Thurston, J.H., Hauhart, R.E., Naccarato, E.F. Science (1981) [Pubmed]
  10. Hypernatremia induced by maximal exercise. Felig, P., Johnson, C., Levitt, M., Cunningham, J., Keefe, F., Boglioli, B. JAMA (1982) [Pubmed]
  11. Effects of hypernatremia on organic brain osmoles. Lien, Y.H., Shapiro, J.I., Chan, L. J. Clin. Invest. (1990) [Pubmed]
  12. Pyruvate carboxylase deficiency: metabolic characteristics and new neurological aspects. García-Cazorla, A., Rabier, D., Touati, G., Chadefaux-Vekemans, B., Marsac, C., de Lonlay, P., Saudubray, J.M. Ann. Neurol. (2006) [Pubmed]
  13. Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. Shangraw, R.E., Winter, R., Hromco, J., Robinson, S.T., Gallaher, E.J. Anesthesiology (1994) [Pubmed]
  14. Hypertonic saline-dextran resuscitation from hemorrhagic shock induces transient mixed acidosis. Moon, P.F., Kramer, G.C. Crit. Care Med. (1995) [Pubmed]
  15. Structural, functional and hypertensive effects of 19-oxo-11-deoxycorticosterone acetate (19-oxo-DOCA) in the rat. Hall, C.E., Gomez-Sanchez, C.E., Hungerford, S. Steroids (1983) [Pubmed]
  16. Chronic in utero plasma hyperosmolality alters hypothalamic arginine vasopressin synthesis and pituitary arginine vasopressin content in newborn lambs. Ramirez, B.A., Wang, S., Kallichanda, N., Ross, M.G. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  17. The natriuretic peptide system in eels: a key endocrine system for euryhalinity? Takei, Y., Hirose, S. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  18. Attenuated vascular reactivity in dogs with anteroventral third ventricle lesions. Brum, J.M., Tramposch, A.F., Block, C.H., Estafanous, F.G., Ferrario, C.M. Hypertension (1991) [Pubmed]
  19. Extracellular volume decreases while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. Cserr, H.F., DePasquale, M., Nicholson, C., Patlak, C.S., Pettigrew, K.D., Rice, M.E. J. Physiol. (Lond.) (1991) [Pubmed]
  20. Arcuate nucleus inputs onto subfornical organ neurons that respond to plasma hypernatremia and angiotensin II. Rosas-Arellano, M.P., Solano-Flores, L.P., Ciriello, J. Brain Res. (1996) [Pubmed]
  21. Age-associated changes in the endocrine system. Winger, J.M., Hornick, T. Nurs. Clin. North Am. (1996) [Pubmed]
  22. A question of balance--dehydration in the elderly. Kositzke, J.A. Journal of gerontological nursing. (1990) [Pubmed]
  23. Thyroidectomy does not alter hypothalamic oxytocin and vasopressin expression in chronically hypernatremic rats. Thomas, A., Kim, N.B., Amico, J.A. Life Sci. (1995) [Pubmed]
  24. Cellular effects of guanylin and uroguanylin. Sindić, A., Schlatter, E. J. Am. Soc. Nephrol. (2006) [Pubmed]
  25. Dehydration natriuresis in male rats is mediated by oxytocin. Huang, W., Lee, S.L., Arnason, S.S., Sjöquist, M. Am. J. Physiol. (1996) [Pubmed]
  26. Hypernatremia in hospitalized patients. Palevsky, P.M., Bhagrath, R., Greenberg, A. Ann. Intern. Med. (1996) [Pubmed]
  27. Chronic hypernatremia from a congenital defect in osmoregulation of thirst and vasopressin. Schaff-Blass, E., Robertson, G.L., Rosenfield, R.L. J. Pediatr. (1983) [Pubmed]
  28. Usefulness of plasma exchange plus continuous hemodiafiltration to reduce adverse effects associated with plasma exchange in patients with acute liver failure. Sadahiro, T., Hirasawa, H., Oda, S., Shiga, H., Nakanishi, K., Kitamura, N., Hirano, T. Crit. Care Med. (2001) [Pubmed]
  29. Severe cyanide poisoning from the ingestion of an acetonitrile-containing cosmetic. Turchen, S.G., Manoguerra, A.S., Whitney, C. The American journal of emergency medicine. (1991) [Pubmed]
  30. Effect of intraperitoneal diuretics on solute transport during hypertonic dialysis. Maher, J.F., Hohnadel, D.C., Shea, C., DiSanzo, F., Cassetta, M. Clin. Nephrol. (1977) [Pubmed]
  31. Application of vasopressin radioimmunoassay to clinical study: role of vasopressin in hypo- and hypernatremia and some other disorders of water metabolism. Shimizu, K., Hoshino, M. Contributions to nephrology. (1978) [Pubmed]
  32. Myelodysplastic syndrome with central diabetes insipidus manifesting hypodipsic hypernatremia and dehydration. Nakamura, F., Kishimoto, Y., Handa, T., Arai, Y., Mitani, K. Am. J. Hematol. (2004) [Pubmed]
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