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Gene Review

Il11  -  interleukin 11

Rattus norvegicus

Synonyms: IL-11, Interleukin-11
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Disease relevance of Il11


High impact information on Il11


Chemical compound and disease context of Il11


Biological context of Il11


Anatomical context of Il11


Associations of Il11 with chemical compounds

  • Rats treated with systemic IL-11 showed improved absorption of galactose of 2.39 micromoles/cm(2) (P <.05), and glycine at 2.21 micromoles/cm(2) (P <.05) [1].
  • Cells were incubated in low-serum medium, or in low-serum medium containing progesterone (1 microM), estradiol 17-beta (10 nM), cholera toxin (10 ng/ml) and interleukin-11 (10 ng/ml) [12].
  • IL-11 (20 micrograms/day) was given subcutaneously for 10 days from day 5 after CBDCA treatment [8].

Other interactions of Il11


  1. Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury. Kuenzler, K.A., Pearson, P.Y., Schwartz, M.Z. J. Pediatr. Surg. (2002) [Pubmed]
  2. Trophic effects of interleukin-11 in rats with experimental short bowel syndrome. Liu, Q., Du, X.X., Schindel, D.T., Yang, Z.X., Rescorla, F.J., Williams, D.A., Grosfeld, J.L. J. Pediatr. Surg. (1996) [Pubmed]
  3. Endogenous interleukin-11 (IL-11) expression is increased and prophylactic use of exogenous IL-11 enhances platelet recovery and improves survival during thrombocytopenia associated with experimental group B streptococcal sepsis in neonatal rats. Chang, M., Williams, A., Ishizawa, L., Knoppel, A., van de Ven, C., Cairo, M.S. Blood Cells Mol. Dis. (1996) [Pubmed]
  4. Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats. Gibson, R.J., Keefe, D.M., Thompson, F.M., Clarke, J.M., Goland, G.J., Cummins, A.G. Dig. Dis. Sci. (2002) [Pubmed]
  5. The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines. Perez Castro, C., Nagashima, A.C., Pereda, M.P., Goldberg, V., Chervin, A., Largen, P., Renner, U., Stalla, G.K., Arzt, E. Endocrinology (2000) [Pubmed]
  6. A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease. Carvey, P.M., Ling, Z.D., Sortwell, C.E., Pitzer, M.R., McGuire, S.O., Storch, A., Collier, T.J. Exp. Neurol. (2001) [Pubmed]
  7. The combined effects of interleukin-11, stem cell factor, and granulocyte colony-stimulating factor on newborn rat hematopoiesis: significant enhancement of the absolute neutrophil count. Cairo, M.S., Plunkett, J.M., Schendel, P., van de Ven, C. Exp. Hematol. (1994) [Pubmed]
  8. Effects of interleukin-11 on carboplatin-induced thrombocytopenia in rats and in combination with stem cell factor. Yonemura, Y., Kawakita, M., Miyake, H., Miyazoe, T., Fujimoto, K., Takatsuki, K. Int. J. Hematol. (1997) [Pubmed]
  9. Interleukin-11 inhibits bone formation in vitro. Hughes, F.J., Howells, G.L. Calcif. Tissue Int. (1993) [Pubmed]
  10. IL-11 pretreatment reduces cell death after intestinal ischemia-reperfusion. Kuenzler, K.A., Pearson, P.Y., Schwartz, M.Z. J. Surg. Res. (2002) [Pubmed]
  11. Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection. Fiore, N.F., Ledniczky, G., Liu, Q., Orazi, A., Du, X., Williams, D.A., Grosfeld, J.L. J. Pediatr. Surg. (1998) [Pubmed]
  12. Stimulation of a rat uterine stromal cell line in culture reveals a molecular switch for endocrine-dependent differentiation. Rider, V., Potapova, T., Dai, G., Soares, M.J. J. Endocrinol. (2005) [Pubmed]
  13. Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor. Coyle, P., Philcox, J.C., Rofe, A.M. Inflamm. Res. (1995) [Pubmed]
  14. Effects of interleukin-11 and epidermal growth factor on residual small intestine after experimental massive small bowel resection. Ledniczky, G., Fiore, N., Bognár, G., Ondrejka, P., Grosfeld, J.L. Chirurgia (Bucharest, Romania : 1990) (2006) [Pubmed]
  15. Regulation of hepatic cytochrome P450 2C11 by transforming growth factor-beta, hepatocyte growth factor, and interleukin-11. Iber, H., Morgan, E.T. Drug Metab. Dispos. (1998) [Pubmed]
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