Disease relevance of Il11

• This study was designed to examine the effects of systemic IL-11 on small bowel absorptive function in a rat model of intestinal ischemia and reperfusion (IR) injury [1].
• Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury [1].
• Trophic effects of interleukin-11 in rats with experimental short bowel syndrome [2].
• This increase in IL-11 gene expression, however, does not appear to prevent severe thrombocytopenia [3].
• We conclude that IL-11 attenuated mucositis by maintaining intestinal weight and morphometry [4].

High impact information on Il11

• The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines [5].
• We have shown that mitotic progenitor cells can be isolated from embryonic rat mesencephalon and that these cells respond to a combination of interleukin-1, interleukin-11, leukemia inhibitory factor, and glial cell line-derived neurotrophic factor yielding a tyrosine hydroxylase-immunoreactive (THir) phenotype in 20-25% of total cells [6].
• We have previously examined the effects of granulocyte colony-stimulating factor (G-CSF) alone or in combination with either stem cell factor (SCF) or interleukin-11 (IL-11) on in vivo neonatal rat hematopoiesis [7].
• In this study, we determined the effect of the triple combination of IL-11, SCF, and G-CSF on newborn rat hematopoiesis [7].
• The combined effects of interleukin-11, stem cell factor, and granulocyte colony-stimulating factor on newborn rat hematopoiesis: significant enhancement of the absolute neutrophil count [7].

Chemical compound and disease context of Il11

• Effects of interleukin-11 on carboplatin-induced thrombocytopenia in rats and in combination with stem cell factor [8].
• Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats [4].

Biological context of Il11

• These data suggest that the combination of two early-lineage CSFs, IL-11 plus SCF and G-CSF, significantly induces newborn rat myelopoiesis and that IL-11 alone significantly induces newborn rat thrombopoiesis [7].
• The circulating platelet counts, however, significantly increased during each of the IL-11 treatment arms, but they were not enhanced by the addition of either SCF, G-CSF, or the combination [7].
• Interleukin-11 inhibits bone formation in vitro [9].
• IL-11 did not affect tumor apoptosis or proliferation [4].
• IL-11 did not prevent apoptosis, but rather induced compensatory crypt cell proliferation [4].

Anatomical context of Il11

• Rats were divided into 3 groups: sham operation/systemic saline; 30-minute superior mesenteric artery occlusion/systemic saline; superior mesenteric artery occlusion/systemic IL-11, 750 microgram/kg/d. After the infusion, (14)C-galactose or (14)C-glycine absorption was measured using an in vivo, recirculation technique [1].
• The triple combination of IL-11, SCF, and G-CSF induced the most significant increase in the circulating absolute neutrophil count (ANC) above any other combination or placebo [7].
• These data indicate that following IR injury, IL-11 improves enterocyte survival by reducing necrosis and apoptosis [10].
• This study evaluates whether IL-11 can improve the function and structure of the small intestine and enhance adaptation in an experimental model of short bowel syndrome [2].
• BACKGROUND/PURPOSE: Interleukin-11 (IL-11) is a multifunctional cytokine derived from bone marrow, which has a trophic effect on small bowel epithelium [11].

Associations of Il11 with chemical compounds

• Rats treated with systemic IL-11 showed improved absorption of galactose of 2.39 micromoles/cm(2) (P <.05), and glycine at 2.21 micromoles/cm(2) (P <.05) [1].
• Cells were incubated in low-serum medium, or in low-serum medium containing progesterone (1 microM), estradiol 17-beta (10 nM), cholera toxin (10 ng/ml) and interleukin-11 (10 ng/ml) [12].
• IL-11 (20 micrograms/day) was given subcutaneously for 10 days from day 5 after CBDCA treatment [8].

Other interactions of Il11

• Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor [13].
• IL-11, with or without EGF may be a useful adjunct in treatment of short bowel syndrome [14].
• Neither IL-11 nor LIF enhanced the response obtained with Zn+Dex+IL-6 [13].
• Here, we show that transforming growth factor-beta, hepatocyte growth factor, and interleukin-11 are potent inhibitors of 2C11 expression [15].
• CONCLUSIONS: IL-11 pretreatment reduced crypt cell apoptosis after IR injury, possibly by upregulating Bcl-2 [10].

References