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Gene Review

Nfkbib  -  nuclear factor of kappa light polypeptide...

Mus musculus

Synonyms: I-kappa-B-beta, IKB-beta, IKappaBbeta, IkB, IkB-B, ...
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Disease relevance of Nfkbib


High impact information on Nfkbib

  • The knock-in mice do not express IkappaBalpha, but express a T7-tagged IkappaBbeta under the promoter and regulatory sequence of ikba [5].
  • IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation [6].
  • Chemical cross-linking and coimmunoprecipitation show that NFkappaB/Rel factor-bound IkappaBbeta forms a ternary complex with Cn under in vitro and in vivo conditions that was sensitive to FK506 [7].
  • Results show that phosphorylation at S313 and S315 from the COOH-terminal PEST domain of IkappaBbeta is critical for binding to Cn [7].
  • Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta [7].

Biological context of Nfkbib


Anatomical context of Nfkbib


Associations of Nfkbib with chemical compounds


Physical interactions of Nfkbib


Other interactions of Nfkbib

  • Mutations at S313/S315 of IkappaBbeta abolished Cn binding, inhibited Cn-mediated increase of Rel proteins in the nucleus, and had a dominant-negative effect on the mitochondrial stress-induced expression of RyR1 and cathepsin L genes [7].
  • Activation of this pathway requires the PKR-dependent degradation of the IkappaBbeta protein [20].
  • When the effect of pro-inflammatory cytokines was investigated, tumor necrosis factor alpha, but not interleukin-1 or interferon-gamma, promoted an important degradation of IkappaBbeta followed by an increase in the mRNA at 1 h [13].
  • Moreover, treatment of extracts of resynthesized IkappaBbeta with alkaline phosphatase resulted in the accumulation of the protein of slightly higher electrophoretic mobility, indicating the prevalence of a rapid phosphorylation of the newly synthesized IkappaBbeta [13].

Analytical, diagnostic and therapeutic context of Nfkbib


  1. Inhibition of anchorage-independent growth and lung metastasis of A549 lung carcinoma cells by IkappaBbeta. Jiang, Y., Cui, L., Yie, T.A., Rom, W.N., Cheng, H., Tchou-Wong, K.M. Oncogene (2001) [Pubmed]
  2. Menadione cytotoxicity to Hep G2 cells and protection by activation of nuclear factor-kappaB. Chen, Q., Cederbaum, A.I. Mol. Pharmacol. (1997) [Pubmed]
  3. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. MacMaster, J.F., Dambach, D.M., Lee, D.B., Berry, K.K., Qiu, Y., Zusi, F.C., Burke, J.R. Inflamm. Res. (2003) [Pubmed]
  4. Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Feinstein, D.L., Galea, E., Gavrilyuk, V., Brosnan, C.F., Whitacre, C.C., Dumitrescu-Ozimek, L., Landreth, G.E., Pershadsingh, H.A., Weinberg, G., Heneka, M.T. Ann. Neurol. (2002) [Pubmed]
  5. Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta. Cheng, J.D., Ryseck, R.P., Attar, R.M., Dambach, D., Bravo, R. J. Exp. Med. (1998) [Pubmed]
  6. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. Fan, C., Li, Q., Zhang, Y., Liu, X., Luo, M., Abbott, D., Zhou, W., Engelhardt, J.F. J. Clin. Invest. (2004) [Pubmed]
  7. Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. Biswas, G., Anandatheerthavarada, H.K., Zaidi, M., Avadhani, N.G. J. Cell Biol. (2003) [Pubmed]
  8. Assignment of Nfkbib to murine chromosome bands 7A3-B3 by in situ hybridization. Klein, B.S., Liptay, S., Schmid, R.M., Hameister, H. Cytogenet. Cell Genet. (1999) [Pubmed]
  9. RelA/p65 regulation of IkappaBbeta. Hertlein, E., Wang, J., Ladner, K.J., Bakkar, N., Guttridge, D.C. Mol. Cell. Biol. (2005) [Pubmed]
  10. Cloning and characterization of the gene encoding mouse IkappaBbeta. Budde, L.M., Ghosh, S. Gene (2000) [Pubmed]
  11. Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation. Hauf, N., Goebel, W., Fiedler, F., Sokolovic, Z., Kuhn, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. Identification of a novel NF-kappaB p50-related protein in B lymphocytes. Phillips, R.J., Gustafson, S., Ghosh, S. Mol. Cell. Biol. (1996) [Pubmed]
  13. Rapid Up-regulation of IkappaBbeta and abrogation of NF-kappaB activity in peritoneal macrophages stimulated with lipopolysaccharide. Velasco, M., Díaz-Guerra, M.J., Martín-Sanz, P., Alvarez, A., Boscá, L. J. Biol. Chem. (1997) [Pubmed]
  14. Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation. Kim, H.T., Qiang, W., Wong, P.K., Stoica, G. J. Neurovirol. (2001) [Pubmed]
  15. Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha. Weil, R., Laurent-Winter, C., Israël, A. J. Biol. Chem. (1997) [Pubmed]
  16. Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. Wright, G., Singh, I.S., Hasday, J.D., Farrance, I.K., Hall, G., Cross, A.S., Rogers, T.B. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  17. Proteasome regulation of activation-induced T cell death. Cui, H., Matsui, K., Omura, S., Schauer, S.L., Matulka, R.A., Sonenshein, G.E., Ju, S.T. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock. McDonald, M.C., Mota-Filipe, H., Paul, A., Cuzzocrea, S., Abdelrahman, M., Harwood, S., Plevin, R., Chatterjee, P.K., Yaqoob, M.M., Thiemermann, C. FASEB J. (2001) [Pubmed]
  19. Preparation and crystallization of dynamic NF-kappa B.Ikappa B complexes. Huxford, T., Malek, S., Ghosh, G. J. Biol. Chem. (2000) [Pubmed]
  20. Induction of E-selectin expression by double-stranded RNA and TNF-alpha is attenuated in murine aortic endothelial cells derived from double-stranded RNA-activated kinase (PKR)-null mice. Bandyopadhyay, S.K., de La Motte, C.A., Williams, B.R. J. Immunol. (2000) [Pubmed]
  21. Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome. Jaffray, C., Yang, J., Carter, G., Mendez, C., Norman, J. Surgery (2000) [Pubmed]
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