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Gene Review

Vip  -  vasoactive intestinal polypeptide

Mus musculus

Synonyms: PHI, peptide histidine isoleucine, VIP peptides
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Disease relevance of Vip


Psychiatry related information on Vip


High impact information on Vip


Chemical compound and disease context of Vip


Biological context of Vip


Anatomical context of Vip


Associations of Vip with chemical compounds


Physical interactions of Vip


Regulatory relationships of Vip


Other interactions of Vip

  • In cells isolated from iNOS knockout mice, VIP still induced full relaxation but it was not influenced by L-NA or 1400W [19].
  • Mouse ES cells were allowed to aggregate in embryoid bodies (EBs) in the presence or not of VIP and PACAP for 1 week [15].
  • In addition, VIPR1 mRNA was detected in splenic T lymphocytes, but no signal was obtained for VIPR2 mRNA, even after stimulation of the cells with anti-CD3(epsilon)-chain mAb, phorbol 12-myristate 13-acetate (PMA) and/or VIP [20].
  • CCK and VIP levels in plasma and small intestine in mice were measured by radioimmunoassay (RIA) [6].
  • VIP and CGRP had small relaxant effects [26].

Analytical, diagnostic and therapeutic context of Vip


  1. Vasoactive intestinal polypeptide suppressed experimental autoimmune encephalomyelitis by inhibiting T helper 1 responses. Li, H., Mei, Y., Wang, Y., Xu, L. J. Clin. Immunol. (2006) [Pubmed]
  2. Neuropeptides in dissociated cell cultures of mammalian spinal cord and dorsal root ganglion. Matthew, E. Int. J. Dev. Neurosci. (1993) [Pubmed]
  3. Neuropeptide immunoreactivity and choline acetyltransferase activity in the mouse urinary bladder following inoculation with Semliki Forest Virus. Moss, H.E., Tansey, E.M., Milner, P., Lincoln, J., Burnstock, G. J. Auton. Nerv. Syst. (1990) [Pubmed]
  4. Altered levels of neuropeptides characterize the brain of lupus prone mice. Bracci-Laudiero, L., Aloe, L., Lundeberg, T., Theodorsson, E., Stenfors, C. Neurosci. Lett. (1999) [Pubmed]
  5. Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein. Cabanes, D., Sousa, S., Cebriá, A., Lecuit, M., García-del Portillo, F., Cossart, P. EMBO J. (2005) [Pubmed]
  6. Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice. Cao, S.G., Wu, W.C., Han, Z., Wang, M.Y. World J. Gastroenterol. (2005) [Pubmed]
  7. VIP and noradrenaline act synergistically to increase cyclic AMP in cerebral cortex. Magistretti, P.J., Schorderet, M. Nature (1984) [Pubmed]
  8. Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Aton, S.J., Colwell, C.S., Harmar, A.J., Waschek, J., Herzog, E.D. Nat. Neurosci. (2005) [Pubmed]
  9. Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum. Ikuno, N., Soda, H., Watanabe, M., Oka, M. J. Natl. Cancer Inst. (1995) [Pubmed]
  10. Expression of vasoactive intestinal polypeptide and amylase in a human parotid gland adenocarcinoma cell line in culture. Hayashi, Y., Yanagawa, T., Yoshida, H., Azuma, M., Nishida, T., Yura, Y., Sato, M. J. Natl. Cancer Inst. (1987) [Pubmed]
  11. Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin. Inukai, T., Chik, C.L., Ho, A.K. Peptides (1994) [Pubmed]
  12. Synthesis and release of vasoactive intestinal polypeptide (VIP) by mouse neuroblastoma cells: modulation by cyclic nucleotides and ascorbic acid. Brick, P.L., Howlett, A.C., Beinfeld, M.C. Peptides (1985) [Pubmed]
  13. Ontogeny of enkephalin- and VIP-containing neurons in dissociated cultures of embryonic mouse spinal cord and dorsal root ganglia. Eiden, L.E., Siegel, R.E., Giraud, P., Brenneman, D.E. Brain Res. Dev. Brain Res. (1988) [Pubmed]
  14. Clues to VIP function from knockout mice. Hamidi, S.A., Szema, A.M., Lyubsky, S., Dickman, K.G., Degene, A., Mathew, S.M., Waschek, J.A., Said, S.I. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  15. VIP and PACAP induce selective neuronal differentiation of mouse embryonic stem cells. Cazillis, M., Gonzalez, B.J., Billardon, C., Lombet, A., Fraichard, A., Samarut, J., Gressens, P., Vaudry, H., Rostène, W. Eur. J. Neurosci. (2004) [Pubmed]
  16. Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro. Ogasawara, M., Murata, J., Ayukawa, K., Saimi, I. Cancer Lett. (1997) [Pubmed]
  17. Pituitary adenylate cyclase-activating polypeptide induces cAMP production independently from vasoactive intestinal polypeptide in osteoblast-like cells. Suzuki, A., Kotoyori, J., Oiso, Y., Kozawa, O. Cell. Signal. (1994) [Pubmed]
  18. Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism. Magistretti, P.J., Morrison, J.H., Shoemaker, W.J., Sapin, V., Bloom, F.E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice. Dick, J.M., Van Molle, W., Brouckaert, P., Lefebvre, R.A. J. Physiol. (Lond.) (2002) [Pubmed]
  20. Differential expression of vasoactive intestinal polypeptide receptor 1 and 2 mRNA in murine intestinal T lymphocyte subtypes. Qian, B.F., Hammarström, M.L., Danielsson, A. J. Neuroendocrinol. (2001) [Pubmed]
  21. The effect of somatostatin analogue octreotide on amylase secretion from mouse pancreatic acini. Ishiguro, H., Hayakawa, T., Kondo, T., Shibata, T., Kitagawa, M., Sakai, Y., Sobajima, H., Nakae, Y., Tanikawa, M. Digestion (1993) [Pubmed]
  22. Vasoactive intestinal polypeptide receptors linked to an adenylate cyclase, and their relationship with biogenic amine- and somatostatin-sensitive adenylate cyclases on central neuronal and glial cells in primary cultures. Chneiweiss, H., Glowinski, J., Prémont, J. J. Neurochem. (1985) [Pubmed]
  23. Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling. Brown, T.M., Hughes, A.T., Piggins, H.D. J. Neurosci. (2005) [Pubmed]
  24. The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro. Cutler, D.J., Haraura, M., Reed, H.E., Shen, S., Sheward, W.J., Morrison, C.F., Marston, H.M., Harmar, A.J., Piggins, H.D. Eur. J. Neurosci. (2003) [Pubmed]
  25. Influences of gastro-intestinal polypeptides and glucose on glucagon secretion induced by cholinergic stimulation. Ahrén, B., Lundquist, I. Horm. Metab. Res. (1982) [Pubmed]
  26. Morphological and functional in vitro and in vivo characterization of the mouse corpus cavernosum. Mizusawa, H., Hedlund, P., Håkansson, A., Alm, P., Andersson, K.E. Br. J. Pharmacol. (2001) [Pubmed]
  27. Distribution and development of peptidergic nerves and gut endocrine cells in mice with congenital aganglionic colon, and their normal littermates. Vaillant, C., Bu'lock, A., Dimaline, R., Dockray, G.J. Gastroenterology (1982) [Pubmed]
  28. Vasoactive intestinal polypeptide induces analgesia and impairs the antinociceptive effect of morphine in mice. Mácsai, M., Szabó, G., Telegdy, G. Neuropeptides (1998) [Pubmed]
  29. Antigen recognition by an antibody light chain. Sun, M., Li, L., Gao, Q.S., Paul, S. J. Biol. Chem. (1994) [Pubmed]
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