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Gene Review

Cntf  -  ciliary neurotrophic factor

Mus musculus

Synonyms: AI429687, CNTF, Ciliary neurotrophic factor
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Disease relevance of Cntf


Psychiatry related information on Cntf


High impact information on Cntf


Chemical compound and disease context of Cntf


Biological context of Cntf


Anatomical context of Cntf


Associations of Cntf with chemical compounds

  • In Contrast to AAV-Mediated Cntf Expression, AAV-Mediated Gdnf Expression Enhances Gene Replacement Therapy in Rodent Models of Retinal Degeneration [12].
  • In vitro, CNTF only marginally affected TNF production by LPS-stimulated mouse splenocytes, but it acted synergistically with dexamethasone (DEX) in inhibiting TNF production [2].
  • CNTF was found to increase the number of surviving neurons and to enhance the release of radiolabeled Ch/ACh; the other factors were without effect [13].
  • Both leptin and CNTF reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the ARC and PVN of control-fed mice [14].
  • As interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor were previously reported to inhibit the production of tumor necrosis factor (TNF), we studied the effect of CT-1 on serum and heart TNF levels in mice treated with lipopolysaccharide (100 ng/mouse, iv) [15].

Physical interactions of Cntf


Regulatory relationships of Cntf


Other interactions of Cntf


Analytical, diagnostic and therapeutic context of Cntf


  1. Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Sleeman, M.W., Garcia, K., Liu, R., Murray, J.D., Malinova, L., Moncrieffe, M., Yancopoulos, G.D., Wiegand, S.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Ciliary neurotrophic factor inhibits brain and peripheral tumor necrosis factor production and, when coadministered with its soluble receptor, protects mice from lipopolysaccharide toxicity. Benigni, F., Villa, P., Demitri, M.T., Sacco, S., Sipe, J.D., Lagunowich, L., Panayotatos, N., Ghezzi, P. Mol. Med. (1995) [Pubmed]
  3. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Lambert, P.D., Anderson, K.D., Sleeman, M.W., Wong, V., Tan, J., Hijarunguru, A., Corcoran, T.L., Murray, J.D., Thabet, K.E., Yancopoulos, G.D., Wiegand, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Cytokine signal transduction in P19 embryonal carcinoma cells: regulation of Stat3-mediated transactivation occurs independently of p21ras-Erk signaling. van Puijenbroek, A.A., van der Saag, P.T., Coffer, P.J. Exp. Cell Res. (1999) [Pubmed]
  5. Ciliary neurotrophic factor restores gallbladder contractility in leptin-resistant obese diabetic mice. Graewin, S.J., Kiely, J.M., Svatek, C.L., Pitt, H.A. J. Surg. Res. (2006) [Pubmed]
  6. Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease. Rubinsztein, D.C., Leggo, J., Chiano, M., Korn, S., Dodge, A., Norbury, G., Rosser, E., Craufurd, D. Neurology (1997) [Pubmed]
  7. The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Robinson, R.C., Grey, L.M., Staunton, D., Vankelecom, H., Vernallis, A.B., Moreau, J.F., Stuart, D.I., Heath, J.K., Jones, E.Y. Cell (1994) [Pubmed]
  8. CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Linker, R.A., Mäurer, M., Gaupp, S., Martini, R., Holtmann, B., Giess, R., Rieckmann, P., Lassmann, H., Toyka, K.V., Sendtner, M., Gold, R. Nat. Med. (2002) [Pubmed]
  9. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Janoschek, R., Plum, L., Koch, L., Münzberg, H., Diano, S., Shanabrough, M., Müller, W., Horvath, T.L., Brüning, J.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Leptin receptor-mediated regulation of cholinergic neurotransmitter phenotype in cells of central nervous system origin. Di Marco, A., Demartis, A., Gloaguen, I., Lazzaro, D., Delmastro, P., Ciliberto, G., Laufer, R. Eur. J. Biochem. (2000) [Pubmed]
  11. Early onset of degenerative changes at nodes of Ranvier in alpha-motor axons of Cntf null (-/-) mutant mice. Gatzinsky, K.P., Holtmann, B., Daraie, B., Berthold, C.H., Sendtner, M. Glia (2003) [Pubmed]
  12. In Contrast to AAV-Mediated Cntf Expression, AAV-Mediated Gdnf Expression Enhances Gene Replacement Therapy in Rodent Models of Retinal Degeneration. Buch, P.K., Maclaren, R.E., Dur??n, Y., Balaggan, K.S., Macneil, A., Schlichtenbrede, F.C., Smith, A.J., Ali, R.R. Mol. Ther. (2006) [Pubmed]
  13. Growth factor dependent cholinergic function and survival in primary mouse spinal cord cultures. Sheridan, R.E., Adler, M. Life Sci. (2006) [Pubmed]
  14. Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. Steinberg, G.R., Watt, M.J., Fam, B.C., Proietto, J., Andrikopoulos, S., Allen, A.M., Febbraio, M.A., Kemp, B.E. Endocrinology (2006) [Pubmed]
  15. Cardiotrophin-1 inhibits tumor necrosis factor production in the heart and serum of lipopolysaccharide-treated mice and in vitro in mouse blood cells. Benigni, F., Sacco, S., Pennica, D., Ghezzi, P. Am. J. Pathol. (1996) [Pubmed]
  16. Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. MacLennan, A.J., Gaskin, A.A., Vinson, E.N., Martinez, L.C. Eur. J. Pharmacol. (1996) [Pubmed]
  17. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Benigni, F., Fantuzzi, G., Sacco, S., Sironi, M., Pozzi, P., Dinarello, C.A., Sipe, J.D., Poli, V., Cappelletti, M., Paonessa, G., Pennica, D., Panayotatos, N., Ghezzi, P. Blood (1996) [Pubmed]
  18. Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells. Conover, J.C., Ip, N.Y., Poueymirou, W.T., Bates, B., Goldfarb, M.P., DeChiara, T.M., Yancopoulos, G.D. Development (1993) [Pubmed]
  19. Activation of STAT3 signaling in axotomized neurons and reactive astrocytes after fimbria-fornix transection. Schubert, K.O., Naumann, T., Schnell, O., Zhi, Q., Steup, A., Hofmann, H.D., Kirsch, M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2005) [Pubmed]
  20. Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Ozawa, Y., Nakao, K., Shimazaki, T., Takeda, J., Akira, S., Ishihara, K., Hirano, T., Oguchi, Y., Okano, H. Mol. Cell. Neurosci. (2004) [Pubmed]
  21. Functional requirement of gp130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells. Koshimizu, U., Taga, T., Watanabe, M., Saito, M., Shirayoshi, Y., Kishimoto, T., Nakatsuji, N. Development (1996) [Pubmed]
  22. Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. Arce, V., Garces, A., de Bovis, B., Filippi, P., Henderson, C., Pettmann, B., deLapeyrière, O. J. Neurosci. Res. (1999) [Pubmed]
  23. The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. Shimazaki, T., Shingo, T., Weiss, S. J. Neurosci. (2001) [Pubmed]
  24. Essential function of LIF receptor in motor neurons. Li, M., Sendtner, M., Smith, A. Nature (1995) [Pubmed]
  25. Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. Holtmann, B., Wiese, S., Samsam, M., Grohmann, K., Pennica, D., Martini, R., Sendtner, M. J. Neurosci. (2005) [Pubmed]
  26. Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice. Sendtner, M., Götz, R., Holtmann, B., Thoenen, H. J. Neurosci. (1997) [Pubmed]
  27. Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis. Kaibara, A., Espat, N.J., Auffenberg, T., Abouhamze, A.S., Martin, D., Kalra, S., Moldawer, L.L. Cytokine (1998) [Pubmed]
  28. Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Ikeda, K., Wong, V., Holmlund, T.H., Greene, T., Cedarbaum, J.M., Lindsay, R.M., Mitsumoto, H. Ann. Neurol. (1995) [Pubmed]
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