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Gene Review

Terc  -  telomerase RNA component

Mus musculus

Synonyms: mTER, mTR
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Disease relevance of Terc


High impact information on Terc


Biological context of Terc

  • To determine whether telomere shortening leads to a cardiac phenotype, we studied heart function in the telomerase knockout mouse, Terc-/-. We studied Terc-/- mice at the second, G2, and fifth, G5, generation [2].
  • Finally, G5 Terc(-/-) hypersensitivity to MNU supports the notion that short telomeres interfere with proper DNA damage repair [5].
  • Although a few transcripts are modulated specifically in Ku86- or Terc-deficient cells, the observed transcriptional response is mainly inductive and qualitatively similar for all three genotypes, with highest transcriptional induction observed in double mutant G3 Terc-/-/Ku86-/- cells compared with either single mutant [9].
  • We show here that in meiotic chromosome ends of late generation Terc-/- mice telomeric TTAGGG repeats and the TRF1 telomere-binding protein are significantly reduced or below detection level [10].
  • The influence of critical telomeric attrition, a well-known trigger of apoptosis and cell arrest, on sperm DNA fragmentation was studied in late-generation knockout mice for Terc, the RNA component of telomerase, as a model of choice [11].

Anatomical context of Terc


Associations of Terc with chemical compounds


Regulatory relationships of Terc


Other interactions of Terc


Analytical, diagnostic and therapeutic context of Terc


  1. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Rudolph, K.L., Millard, M., Bosenberg, M.W., DePinho, R.A. Nat. Genet. (2001) [Pubmed]
  2. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation. Leri, A., Franco, S., Zacheo, A., Barlucchi, L., Chimenti, S., Limana, F., Nadal-Ginard, B., Kajstura, J., Anversa, P., Blasco, M.A. EMBO J. (2003) [Pubmed]
  3. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Du, X., Shen, J., Kugan, N., Furth, E.E., Lombard, D.B., Cheung, C., Pak, S., Luo, G., Pignolo, R.J., DePinho, R.A., Guarente, L., Johnson, F.B. Mol. Cell. Biol. (2004) [Pubmed]
  4. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. González-Suárez, E., Samper, E., Flores, J.M., Blasco, M.A. Nat. Genet. (2000) [Pubmed]
  5. Telomere dysfunction results in enhanced organismal sensitivity to the alkylating agent N-methyl-N-nitrosourea. González-Suárez, E., Goytisolo, F.A., Flores, J.M., Blasco, M.A. Cancer Res. (2003) [Pubmed]
  6. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Hao, L.Y., Armanios, M., Strong, M.A., Karim, B., Feldser, D.M., Huso, D., Greider, C.W. Cell (2005) [Pubmed]
  7. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., Greider, C.W. Cell (1997) [Pubmed]
  8. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. Goytisolo, F.A., Samper, E., Martín-Caballero, J., Finnon, P., Herrera, E., Flores, J.M., Bouffler, S.D., Blasco, M.A. J. Exp. Med. (2000) [Pubmed]
  9. Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models. Franco, S., Canela, A., Klatt, P., Blasco, M.A. Carcinogenesis (2005) [Pubmed]
  10. Mammalian meiotic telomeres: composition and ultrastructure in telomerase-deficient mice. Franco, S., Alsheimer, M., Herrera, E., Benavente, R., Blasco, M.A. Eur. J. Cell Biol. (2002) [Pubmed]
  11. Critically short telomeres are associated with sperm DNA fragmentation. Rodríguez, S., Goyanes, V., Segrelles, E., Blasco, M., Gosálvez, J., Fernández, J.L. Fertil. Steril. (2005) [Pubmed]
  12. Genomic instability in both wild-type and telomerase null MEFs. Hao, L.Y., Greider, C.W. Chromosoma (2004) [Pubmed]
  13. DNA repair factors and telomere-chromosome integrity in mammalian cells. Hande, M.P. Cytogenet. Genome Res. (2004) [Pubmed]
  14. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. Herrera, E., Samper, E., Martín-Caballero, J., Flores, J.M., Lee, H.W., Blasco, M.A. EMBO J. (1999) [Pubmed]
  15. Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. Herrera, E., Samper, E., Blasco, M.A. EMBO J. (1999) [Pubmed]
  16. The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. Cayuela, M.L., Flores, J.M., Blasco, M.A. EMBO Rep. (2005) [Pubmed]
  17. Genetic analysis of myc and telomerase interactions in vivo. Flores, I., Evan, G., Blasco, M.A. Mol. Cell. Biol. (2006) [Pubmed]
  18. Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system. Martin-Rivera, L., Blasco, M.A. J. Biol. Chem. (2001) [Pubmed]
  19. Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis. Qi, L., Strong, M.A., Karim, B.O., Armanios, M., Huso, D.L., Greider, C.W. Cancer Res. (2003) [Pubmed]
  20. Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Niida, H., Shinkai, Y., Hande, M.P., Matsumoto, T., Takehara, S., Tachibana, M., Oshimura, M., Lansdorp, P.M., Furuichi, Y. Mol. Cell. Biol. (2000) [Pubmed]
  21. Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA. Nosrati, M., Li, S., Bagheri, S., Ginzinger, D., Blackburn, E.H., Debs, R.J., Kashani-Sabet, M. Clin. Cancer Res. (2004) [Pubmed]
  22. A fusion protein of IgG fc and mouse-derived antigen on the surface of pseudorabies virus particles does not accelerate production of harmful auto-reactive antibodies. Ota, H., Takashima, Y., Hayashi, Y., Matsumoto, Y. J. Vet. Med. Sci. (2006) [Pubmed]
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