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Chemical Compound Review

Taurolithocholate     2-[[(4R)-4- [(3R,5R,8S,9S,10S,13R,14S,17R) ...

Synonyms: CHEMBL408701, AG-F-75252, CHEBI:36259, CTK4J4706, LMST05040003, ...
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Disease relevance of TAUROLITHOCHOLIC ACID


High impact information on TAUROLITHOCHOLIC ACID


Chemical compound and disease context of TAUROLITHOCHOLIC ACID


Biological context of TAUROLITHOCHOLIC ACID


Anatomical context of TAUROLITHOCHOLIC ACID


Associations of TAUROLITHOCHOLIC ACID with other chemical compounds



  • Inhibition by oestradiol 3,17-disulphate and taurolithocholate 3-sulphate was competitive, suggesting that these compounds are MRP4 substrates [24].
  • Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep [25].
  • Such vectorial transport was also observed for taurolithocholate sulfate, which is transported by rat oatp1 and Mrp2 [26].
  • Estradiol-17beta-d-glucuronide (E(2)17G) and taurolithocholate (TLC) induce acute cholestasis-associated with retrieval of the bile salt export pump (Bsep), which parallels with alteration in transport activity. cAMP stimulates the apically directed vesicular trafficking of transporters, partially preventing these alterations [27].
  • We evaluated if TC and TLC induction of ABAT expression was dependent on activation of PKC alpha [14].

Analytical, diagnostic and therapeutic context of TAUROLITHOCHOLIC ACID


  1. Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis. Layden, T.J., Schwarz, n.u.l.l., Boyer, J.L. Gastroenterology (1975) [Pubmed]
  2. Pathogenesis of lithocholate- and taurolithocholate-induced intrahepatic cholestasis in rats. Kakis, G., Yousef, I.M. Gastroenterology (1978) [Pubmed]
  3. Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity. Kitada, H., Miyata, M., Nakamura, T., Tozawa, A., Honma, W., Shimada, M., Nagata, K., Sinal, C.J., Guo, G.L., Gonzalez, F.J., Yamazoe, Y. J. Biol. Chem. (2003) [Pubmed]
  4. Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat. Crocenzi, F.A., Mottino, A.D., Sánchez Pozzi, E.J., Pellegrino, J.M., Rodríguez Garay, E.A., Milkiewicz, P., Vore, M., Coleman, R., Roma, M.G. Gut (2003) [Pubmed]
  5. Effects of taurolithocholate, a Ca2(+)-mobilizing agent, on cell Ca2(+) in rat hepatocytes, human platelets and neuroblastoma NG108-15 cell line. Coquil, J.F., Berthon, B., Chomiki, N., Combettes, L., Jourdon, P., Schteingart, C., Erlinger, S., Claret, M. Biochem. J. (1991) [Pubmed]
  6. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Alpini, G., Glaser, S.S., Ueno, Y., Rodgers, R., Phinizy, J.L., Francis, H., Baiocchi, L., Holcomb, L.A., Caligiuri, A., LeSage, G.D. Gastroenterology (1999) [Pubmed]
  7. Taurolithocholate increases heme catabolism and alters the clearance of antipyrine in the rat. Berry, W.R., Kirshenbaum, G., Hoilien, C., Le, M., Reichen, J. Gastroenterology (1985) [Pubmed]
  8. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Beuers, U., Bilzer, M., Chittattu, A., Kullak-Ublick, G.A., Keppler, D., Paumgartner, G., Dombrowski, F. Hepatology (2001) [Pubmed]
  9. Subcellular pathology of rat liver in cholestasis and choleresis induced by bile salts. 1. Effects of lithocholic, 3beta-hydroxy-5-cholenoic, cholic, and dehydrocholic acids. Miyai, K., Richardson, A.L., Mayr, W., Javitt, N.B. Lab. Invest. (1977) [Pubmed]
  10. Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. II. Taurolithocholate-induced alterations of canalicular morphology and of the distribution of filipin-cholesterol complexes. Jung, W., Gebhardt, R., Robenek, H. Eur. J. Cell Biol. (1982) [Pubmed]
  11. 1,3-Butanediol pretreatment on the cholestasis induced in rats by manganese--bilirubin combination, taurolithocholic acid, or alpha-naphthylisothiocyanate. De Lamirande, E., Plaa, G.L. Toxicol. Appl. Pharmacol. (1981) [Pubmed]
  12. Effect of taurolithocholate on in vivo sulfation and glucuronidation of acetaminophen in rats. Galinsky, R.E., Chałasinska, B. Pharm. Res. (1988) [Pubmed]
  13. Sex differences in hepatic sulfation of taurolithocholate in the rat. Hammerman, K.J., Chen, L.J., Fernandez-Corugedo, A., Earnest, D.L. Gastroenterology (1978) [Pubmed]
  14. Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes. Alpini, G., Ueno, Y., Glaser, S.S., Marzioni, M., Phinizy, J.L., Francis, H., Lesage, G. Hepatology (2001) [Pubmed]
  15. Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. Milkiewicz, P., Roma, M.G., Elias, E., Coleman, R. Gut (2002) [Pubmed]
  16. Effect of bile acids on lipid peroxidation: the role of iron. Sreejayan, N., von Ritter, C. Free Radic. Biol. Med. (1998) [Pubmed]
  17. Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver. Schölmerich, J., Baumgartner, U., Miyai, K., Gerok, W. J. Hepatol. (1990) [Pubmed]
  18. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Beuers, U., Probst, I., Soroka, C., Boyer, J.L., Kullak-Ublick, G.A., Paumgartner, G. Hepatology (1999) [Pubmed]
  19. Urinary excretion of lithocholic acid and its conjugates by the bile duct-ligated rat. Little, J.M., Zimniak, P., Radominska, A., Lehman, P., Lester, R. Hepatology (1991) [Pubmed]
  20. Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells. Combettes, L., Dumont, M., Berthon, B., Erlinger, S., Claret, M. J. Biol. Chem. (1988) [Pubmed]
  21. Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated rat hepatocyte couplets. Thibault, N., Maurice, M., Maratrat, M., Cordier, A., Feldmann, G., Ballet, F. J. Hepatol. (1993) [Pubmed]
  22. Effects of bile acids on biliary epithelial cell proliferation and portal fibroblast activation using rat liver slices. Clouzeau-Girard, H., Guyot, C., Combe, C., Moronvalle-Halley, V., Housset, C., Lamireau, T., Rosenbaum, J., Desmoulière, A. Lab. Invest. (2006) [Pubmed]
  23. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. Sokol, R.J., Devereaux, M., Khandwala, R., O'Brien, K. Hepatology (1993) [Pubmed]
  24. Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Zelcer, N., Reid, G., Wielinga, P., Kuil, A., van der Heijden, I., Schuetz, J.D., Borst, P. Biochem. J. (2003) [Pubmed]
  25. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Hayashi, H., Takada, T., Suzuki, H., Onuki, R., Hofmann, A.F., Sugiyama, Y. Biochim. Biophys. Acta (2005) [Pubmed]
  26. Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). Sasaki, M., Suzuki, H., Ito, K., Abe, T., Sugiyama, Y. J. Biol. Chem. (2002) [Pubmed]
  27. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP. Crocenzi, F.A., Basiglio, C.L., Pérez, L.M., Portesio, M.S., Pozzi, E.J., Roma, M.G. Biochem. Pharmacol. (2005) [Pubmed]
  28. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Almasio, P., Bortolini, M., Pagliaro, L., Coltorti, M. Drugs (1990) [Pubmed]
  29. Reduced cholestatic potency of taurolithocholate during backward perfusion of the rat liver. Baumgartner, U., Hardison, W.G., Miyai, K. Lab. Invest. (1987) [Pubmed]
  30. Cholesterol in acute cholestasis induced by taurolithocholic acid. A cytochemical study in transmission and scanning electron microscopy. Bonvicini, F., Gautier, A., Gardiol, D., Borel, G.A. Lab. Invest. (1978) [Pubmed]
  31. Effect of biliary stasis and hepatotoxins on the excretion of iopanoate in the rat. Cooke, W.J., Berndt, W.O., Mudge, G.H. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
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