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SPESP1  -  sperm equatorial segment protein 1

Homo sapiens

Synonyms: ESP, Equatorial segment protein, Glycosylated 38 kDa sperm protein C-7/8, SP-ESP, Sperm equatorial segment protein 1, ...
 
 
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Disease relevance of SPESP1

  • Evaluation of the ESP culture system II for testing susceptibilities of Mycobacterium tuberculosis isolates to four primary antituberculous drugs [1].
  • Detection of bacteremia by Difco ESP blood culture system [2].
  • BacT/Alert FAN detected more isolates of Staphylococcus aureus (47 versus 34; P = 0.02), while ESP 80A detected more episodes of streptococcal and enterococcal infection [3].
  • A panfungal PCR assay was used to evaluate the ability of the ESP blood culture system to detect fungemia [4].
  • Significantly more episodes of bacteremia caused by Staphylococcus epidermidis and anaerobes were detected by the ESP system [2].
 

Psychiatry related information on SPESP1

  • One or no abnormal responses to the ESP ruled out an eating disorder (likelihood ratio [LR] 0.0), whereas 3 or more abnormal responses ruled one in (LR 11) [5].
  • In this experiment we sought to provide evidence for transliminality from a test of subliminal perception that was disguised as a computerised ESP card-guessing task [6].
  • Of the three subscales to the Australian Sheep-Goat measure, scores for narcissism correlated with belief in ESP and PK but not in Life after death [7].
  • The women had high DES scores, a high number of secondary features of MPD, high rates of depression, borderline personality, substance abuse, somatic symptoms, Schneiderian symptoms, ESP/supernatural experiences, suicide attempts, and conversion symptoms [8].
  • A questionnaire was developed to assess adult recall for a range of transpersonal experiences throughout childhood and adolescence (mystical experience, out-of-body experience, lucid dreams, archetypal dreams, ESP), as well as nightmares and night terrors as indicators of more conflicted, negative states [9].
 

High impact information on SPESP1

  • Upon ESP-MS, EoCP-1 showed an average molecular mass of 8,355 +/- 10 daltons, suggesting O-glycosylation at these serine residues [10].
  • Electrospray mass spectrometry (ESP-MS) of EoCPs revealed for EoCP-2 a molecular mass of 7,862.8 +/- 1.1 daltons, which is 15.8 mass units higher than the calculated value of RANTES, indicating that EoCP-2 is identical to the full-length cytokine, and oxygenation, probably at methionine residue number 64, has taken place [10].
  • Therefore, the ESP EPR signal can be directly attributed to A-1, and vitamin K1 can be assigned as this PSI acceptor [11].
  • Features of drug structure that may limit damage to the nucleosome core include the presence of substituents on both sides of the CAL/ESP-type core, and the presence of an intercalating moiety, such as the naphthoate of NCS and possibly the anthranilate of ESP A1 [12].
  • In nuclei, both NCS and ESP A1 produced DNA damage limited to the linker region of the nucleosome, while CAL and ESP C, an analog of ESP A1 missing the deoxyfucose-anthranilate moiety, damaged both the core and linker DNA [12].
 

Chemical compound and disease context of SPESP1

 

Biological context of SPESP1

  • ESP is the earliest known protein to be recognized as a marker for the specification of the equatorial segment, and it allows this region to be traced through all phases of acrosomal biogenesis [15].
  • Equatorial segment protein (ESP), a novel 349-amino acid concanavalin-A-binding protein encoded by a two-exon gene (SP-ESP) located on chromosome 15 at q22, has been localized to the equatorial segment of ejaculated human sperm [15].
  • DNA damage in HeLa nuclei and isolated nucleosome core particles has been examined for several members of the enediyne family of antitumor antibiotics: calicheamicin gamma 1I (CAL), esperamicin A1 (ESP A1), esperamicin C (ESP C), and neocarzinostatin (NCS) [12].
  • In this paper, a multiple alignment of amino acid sequences was constructed using a shared lipid binding motif as an anchor, to demonstrate that lepidopteran ESP/YP2s, higher-dipteran YPs, and lipoprotein lipases are indeed homologous [16].
  • It has become clear that eosinophols are subject to chemotaxis by attractants that do not affect other cells (e.g., histamine, ECF-A, ESP) and that they contain antiflogistic agents (arylsulfatase IIB, peroxidase) that neutralize specific substances known to elicit the inflammatory response [17].
 

Anatomical context of SPESP1

  • Subsequently, ESP was localized to electron-dense regions of the equatorial segment and the expanded equatorial bulb in elongating spermatids and mature sperm [15].
  • The results indicate that D exerts a mild negative inotropic effect which is more evident in the postextrasystolic beat (postextrasystolic ESP/ESV and dP/dtmax were significantly lower after D) but the postextrasystolic increase of EF is maintained by the effects of the drug on loading conditions of the left ventricle [18].
  • On the basis of the high technical success rate, high sensitivity and specificity, and short examination time, waveform analysis for detection of tardus-parvus abnormalities, especially loss of ESP, of the segmental artery is recommended as an alternative to direct examination of the main renal arteries for evaluation of RAS [19].
  • In experimental series 1 (7 men; 2 women), plasma [K+] was continuously measured in vitro (37 degrees C) after the addition of red blood cells (RBCs) obtained from rested subjects (resting RBCs) into an exercise-simulated plasma (ESP; increased plasma osmolality, [K+], [H+], [lactate] and [adrenaline] (epinephrine)), and JK,net calculated [20].
  • This study suggests a new non-invasive approach for collection of spermatozoa in these patients: the extended sperm preparation (ESP) [21].
 

Associations of SPESP1 with chemical compounds

  • The characteristic electron spin polarized electron paramagnetic resonance (ESP EPR) signal observed in photosystem I (PSI) has been previously assigned to a radical pair composed of the oxidized primary donor and a reduced vitamin K1 [11].
  • DNA fragments produced by CAL and ESP C in the nucleosome core occurred with a 10-11-nucleotide periodicity similar to that produced by DNase I, while damage produced by NCS and ESP A1 appeared to be limited to the terminal portions of the core DNA [12].
  • The ESP EPR signal was not detected in the solvent-extracted PSI sample but was restored upon reconstitution with either protonated or deuterated vitamin K1 under conditions that also restored electron transfer to the terminal PSI acceptors [22].
  • The electron spin polarized (ESP) electron paramagnetic resonance (EPR) signal observed in spinach photosystem I (PSI) particles was examined in preparations depleted of vitamin K1 by solvent extraction and following biological reconstitution by the quinone [22].
  • Solid-phase extraction (SPE) was combined with high-performance liquid chromatography/high-flow pneumatically assisted electrospray mass spectrometry (HPLC/ ESP/MS) for the trace analysis of oxanilic and sulfonic acids of acetochlor, alachlor, and metolachlor [23].
 

Analytical, diagnostic and therapeutic context of SPESP1

  • In a multicenter study, the Difco ESP blood culture system (Difco Laboratories, Detroit, Mich.) was compared with the BACTEC NR660 system (Becton Dickinson Diagnostic Instrument Systems, Sparks, Md.). The ESP system monitors each blood culture bottle every 12 to 24 min to detect changes in oxygen consumption and gas production by microbes [2].
  • RESULTS: Cold ischemic time (ESP vs. controls 501 vs. 883 min; p<0.05) and mean number of HLA mismatches (4.2 +/- 1.36 vs. 1.6 +/- 1.62; p<0.05) differed significantly [24].
  • ESP was performed for 49 patients; in 17 patients (35%), spermatozoa were found and subsequently used in intracytoplasmic sperm injection (ICSI) [21].
  • The process conditions were optimized and the surfaces of these matrices were modified by glow-discharge treatment and/or glutaraldehyde incorporation for immobilization of elastin-derived proteins (ESP) to the matrix to increase the biocompatibility and also to improve the bioactivity of the matrix [25].
  • Scanning electron microscopy (SEM) studies showed that ESP were homogeneously deposited the surface of the matrix [25].

References

  1. Evaluation of the ESP culture system II for testing susceptibilities of Mycobacterium tuberculosis isolates to four primary antituberculous drugs. Bergmann, J.S., Woods, G.L. J. Clin. Microbiol. (1998) [Pubmed]
  2. Detection of bacteremia by Difco ESP blood culture system. Morello, J.A., Leitch, C., Nitz, S., Dyke, J.W., Andruszewski, M., Maier, G., Landau, W., Beard, M.A. J. Clin. Microbiol. (1994) [Pubmed]
  3. Comparison of the BacT/Alert FAN aerobic and the Difco ESP 80A aerobic bottles for pediatric blood cultures. Welby-Sellenriek, P.L., Keller, D.S., Ferrett, R.J., Storch, G.A. J. Clin. Microbiol. (1997) [Pubmed]
  4. Use of a panfungal PCR assay for detection of fungal pathogens in a commercial blood culture system. Iwen, P.C., Freifeld, A.G., Bruening, T.A., Hinrichs, S.H. J. Clin. Microbiol. (2004) [Pubmed]
  5. Four simple questions can help screen for eating disorders. Cotton, M.A., Ball, C., Robinson, P. Journal of general internal medicine : official journal of the Society for Research and Education in Primary Care Internal Medicine. (2003) [Pubmed]
  6. Evidence for transliminality from a subliminal card-guessing task. Crawley, S.E., French, C.C., Yesson, S.A. Perception. (2002) [Pubmed]
  7. Narcissism and belief in the paranormal. Roe, C.A., Morgan, C.L. Psychological reports. (2002) [Pubmed]
  8. Dissociative experiences and disorders among women who identify themselves as sexual abuse survivors. Anderson, G., Yasenik, L., Ross, C.A. Child abuse & neglect. (1993) [Pubmed]
  9. Transpersonal experiences in childhood: an exploratory empirical study of selected adult groups. Hunt, H.T., Gervais, A., Shearing-Johns, S., Travis, F. Perceptual and motor skills. (1992) [Pubmed]
  10. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. Kameyoshi, Y., Dörschner, A., Mallet, A.I., Christophers, E., Schröder, J.M. J. Exp. Med. (1992) [Pubmed]
  11. Direct assignment of vitamin K1 as the secondary acceptor A1 in photosystem I. Snyder, S.W., Rustandi, R.R., Biggins, J., Norris, J.R., Thurnauer, M.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  12. Enediyne-mediated DNA damage in nuclei is modulated at the level of the nucleosome. Yu, L., Goldberg, I.H., Dedon, P.C. J. Biol. Chem. (1994) [Pubmed]
  13. Comparison of the ESP and BACTEC systems for testing susceptibilities of Mycobacterium tuberculosis complex isolates to pyrazinamide. LaBombardi, V.J. J. Clin. Microbiol. (2002) [Pubmed]
  14. Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure. Binkley, P.F., Lewe, R.F., Unverferth, D.V., Leier, C.V. Am. Heart J. (1988) [Pubmed]
  15. Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis. Wolkowicz, M.J., Shetty, J., Westbrook, A., Klotz, K., Jayes, F., Mandal, A., Flickinger, C.J., Herr, J.C. Biol. Reprod. (2003) [Pubmed]
  16. The major yolk proteins of higher Diptera are homologs of a class of minor yolk proteins in lepidoptera. Sappington, T.W. J. Mol. Evol. (2002) [Pubmed]
  17. Eosinophil function related to cutaneous disorders. Zucker-Franklin, D. J. Invest. Dermatol. (1978) [Pubmed]
  18. Effects of diltiazem on postextrasystolic potentiation in coronary heart disease patients. Di Donato, M., Maioli, M., Marchionni, N., Barletta, G.A., Fantini, F. Eur. Heart J. (1990) [Pubmed]
  19. Segmental stenosis of the renal artery: pattern recognition of tardus and parvus abnormalities with duplex sonography. Stavros, A.T., Parker, S.H., Yakes, W.F., Chantelois, A.E., Burke, B.J., Meyers, P.R., Schenck, J.J. Radiology. (1992) [Pubmed]
  20. Exercise-induced changes in plasma composition increase erythrocyte Na+,K+-ATPase, but not Na+-K+-2Cl- cotransporter, activity to stimulate net and unidirectional K+ transport in humans. Lindinger, M.I., Grudzien, S.P. J. Physiol. (Lond.) (2003) [Pubmed]
  21. Extended sperm preparation: an alternative to testicular sperm extraction in non-obstructive azoospermia. Ron-El, R., Strassburger, D., Friedler, S., Komarovski, D., Bern, O., Soffer, Y., Raziel, A. Hum. Reprod. (1997) [Pubmed]
  22. Contribution of vitamin K1 to the electron spin polarization in spinach photosystem I. Rustandi, R.R., Snyder, S.W., Feezel, L.L., Michalski, T.J., Norris, J.R., Thurnauer, M.C., Biggins, J. Biochemistry (1990) [Pubmed]
  23. Identification of ionic chloroacetanilide-herbicide metabolites in surface water and groundwater by HPLC/MS using negative ion spray. Ferrer, I., Thurman, E.M., Barceló, D. Anal. Chem. (1997) [Pubmed]
  24. "Old-for-old" cadaveric renal transplantation: surgical findings, perioperative complications and outcome. Giessing, M., Budde, K., Fritsche, L., Slowinski, T., Tuerk, I., Schoenberger, B., Neumayer, H.H., Loening, S.A. Eur. Urol. (2003) [Pubmed]
  25. Biodegradable biocomposite non-woven matrices based on PDLLA- and elastin-solubilized proteins/elastin. Kozluca, A., Ayhan, H., Rabaud, M., Pişkin, E. Journal of biomaterials science. Polymer edition. (2001) [Pubmed]
 
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