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Gene Review

Il2rb  -  interleukin 2 receptor, beta

Rattus norvegicus

Synonyms: High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, Interleukin-2 receptor subunit beta, ...
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Disease relevance of Il2rb


High impact information on Il2rb

  • Those CD8+ T cells responding in the presence of IL-2 were mainly T cell receptor alpha/beta+ IL-2 receptor (alpha chain)+, and a majority had shifted from high to low CD45R expression [5].
  • Rat IL-2 receptor, not human IL-2 receptor, was expressed on HTLV+ rat cell lines, as demonstrated by the fact that they expressed antigens reactive with monoclonal antibodies (ART-18) against rat IL-2 receptor, but not with anti-Tac antibodies [6].
  • In addition, mRNA for the IL-2 receptor-beta chain was demonstrated by Northern blot analysis using mRNA from primary rat intestinal epithelial cells depleted of detectable contaminating intraepithelial lymphocytes by two cycles of fractionation on Percoll gradients [7].
  • The relevance of observations in the IEC-6 cell line to intestinal mucosa in vivo was supported by the demonstration of a gradient of expression of the IL-2 receptor in primary rat intestinal epithelial cells by Western blot analysis [7].
  • CONCLUSIONS: The results of this study suggest that NO produced by the inducible NO synthase of Kupffer cells in response to lipopolysaccharide modulates the IL-2 receptor expression and LAK activity of splenocytes [8].

Chemical compound and disease context of Il2rb


Biological context of Il2rb


Anatomical context of Il2rb


Associations of Il2rb with chemical compounds


Physical interactions of Il2rb

  • The binding of [125I]human GH to the lactogen receptor as well as the binding of [125I]IL-2 to the IL-2 receptor were decreased in a dose-dependent manner by GTP, GDP, and the analog guanosine 5'-O-(3-thiotriphosphate) [21].

Regulatory relationships of Il2rb

  • Similarly, incubation of NK cells with PRL was not found to induce expression of the alpha chain of the IL-2 receptor (IL-2ra; CD25) on NK cells or other lymphoid cells [22].
  • In the present study, IFN-gamma exposure to primary cultures of rat type II epithelial cells (TIIP) upregulated membrane expression of the common gamma-chain of the IL-2 receptor (approximately 2.5- to 4-fold increase) and redistributed receptor affinity in TIIP, as assessed by Western blot, cell, and tissue histochemistry and Scatchard analysis [23].
  • Markers of immune activation, such as an increase in IL-2-receptor (from 1% +/- 2% to 21% +/- 13%) and class II (from 20% +/- 9% to 43% +/- 13%) expressing lymphoid cells and induction of ICAM-1 in the graft, were consistent with the overall cellular response [24].

Other interactions of Il2rb


Analytical, diagnostic and therapeutic context of Il2rb


  1. Infection by mink cell focus-forming viruses confers interleukin 2 (IL-2) independence to an IL-2-dependent rat T-cell lymphoma line. Tsichlis, P.N., Bear, S.E. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. An IL-2-toxin, DAB389IL-2, inhibits delayed-type hypersensitivity but enhances IgE antibody production. Pullerits, T., Lundin, S., Dahlgren, U., Telemo, E., Hanson, L.A., Lötvall, J. J. Allergy Clin. Immunol. (1999) [Pubmed]
  3. The effect of T cell subset depletion on autoimmune thyroiditis in the Buffalo strain rat. Cohen, S.B., Diamantstein, T., Weetman, A.P. Immunol. Lett. (1990) [Pubmed]
  4. Hypothermia induces T-cell production of immunosuppressive cytokines. Lee, S.L., Battistella, F.D., Go, K. J. Surg. Res. (2001) [Pubmed]
  5. Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system. Sedgwick, J.D., Mössner, R., Schwender, S., ter Meulen, V. J. Exp. Med. (1991) [Pubmed]
  6. Rat lymphoid cell lines producing human T cell leukemia virus. II. Constitutive expression of rat interleukin 2 receptor. Yodoi, J., Okada, M., Tagaya, Y., Teshigawara, K., Fukui, K., Ishida, N., Ikuta, K., Maeda, M., Honjo, T., Osawa, H. J. Exp. Med. (1985) [Pubmed]
  7. Functional interleukin-2 receptors on intestinal epithelial cells. Ciacci, C., Mahida, Y.R., Dignass, A., Koizumi, M., Podolsky, D.K. J. Clin. Invest. (1993) [Pubmed]
  8. Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell. Kurose, I., Miura, S., Saito, H., Tada, S., Fukumura, D., Higuchi, H., Ishii, H. Gastroenterology (1995) [Pubmed]
  9. Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis. Chan, C.C., Caspi, R., Mochizuki, M., Diamantstein, T., Gery, I., Nussenblatt, R.B. Immunol. Invest. (1987) [Pubmed]
  10. Persistence of memory type lymphocytes in an experimental model of chronic pancreatitis in rats. Sparmann, G., Sass, S., Böhme, H.J., Liebe, S., Emmrich, J. Cell. Mol. Biol. (Noisy-le-grand) (2002) [Pubmed]
  11. T cell repertoire alterations of vascularized xenografts. Brouard, S., Vanhove, B., Gagne, K., Neumann, A., Douillard, P., Moreau, A., Cuturi, C., Soulillou, J.P. J. Immunol. (1999) [Pubmed]
  12. Long-term in vivo administration of glucocorticoid hormones attenuates their capacity to accelerate in vitro proliferation of rat splenic T cells. Sterzer, P., Wiegers, G.J., Reul, J.M. Endocrinology (2004) [Pubmed]
  13. Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor gamma chain is required for IL-7 signal transduction. Ziegler, S.E., Morella, K.K., Anderson, D., Kumaki, N., Leonard, W.J., Cosman, D., Baumann, H. Eur. J. Immunol. (1995) [Pubmed]
  14. Rat "first-wave" mature thymocytes: cycling lymphoblasts that are sensitive to activation-induced cell death but rescued by interleukin 2. Lawetzky, A., Kubbies, M., Hünig, T. Eur. J. Immunol. (1991) [Pubmed]
  15. Effects of depletion of cells bearing the interleukin-2 receptor on immunoglobulin production and allergic airway responses in the rat. Renzi, P.M., Yang, J.P., Diamantstein, T., Martin, J.G. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  16. The effects of donor-specific blood transfusion enhancement of rat renal allografts on cytotoxic activity and phenotypes of peripheral blood lymphocytes, splenocytes, and graft-infiltrating cells. Wasowska, B., Baldwin, W.M., Howell, D.N., Sanfilippo, F. Transplantation (1991) [Pubmed]
  17. Effects of the immunosuppressant FK506 on a penetrating keratoplasty rejection model in the rat. Nishi, M., Herbort, C.P., Matsubara, M., Morishita, Y., Nishimura, M., Nieda, M., Mori, S., Mochizuki, M. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  18. Evidence that monoclonal antibodies against the 55kD subunit of the rat IL-2 receptor do not inhibit the development of suppressor cells generated in mixed lymphocyte culture. Tanaka, K., Turka, L.A., Kupiec-Weglinski, J.W., Milford, E.L., Ueda, H., Diamantstein, T., Carpenter, C.B., Tilney, N.L. Transplantation (1990) [Pubmed]
  19. Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death. A model for T-cell apoptosis in vivo. Gold, R., Schmied, M., Tontsch, U., Hartung, H.P., Wekerle, H., Toyka, K.V., Lassmann, H. Brain (1996) [Pubmed]
  20. Partial characterization of the putative rat interleukin 2 receptor. Osawa, H., Diamantstein, T. Eur. J. Immunol. (1984) [Pubmed]
  21. G-proteins modulate prolactin- and interleukin-2-stimulated mitogenesis in rat Nb2 lymphoma cells. Too, C.K., Murphy, P.R., Friesen, H.G. Endocrinology (1989) [Pubmed]
  22. Prolactin receptor expression by rat NK cells. Chambers, W.H., Amoscato, A.A., Smith, M.S., Kenniston, T.W., Herberman, R.B., Appasamy, P.M. Nat. Immun. (1995) [Pubmed]
  23. Role of IFN-gamma and IL-2 in rat lung epithelial cell migration and apoptosis after oxidant injury. Lesur, O., Brisebois, M., Thibodeau, A., Chagnon, F., Lane, D., Füllöp, T. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  24. A rat model of monitoring liver allograft rejection. Martelius, T., Mäkisalo, H., Höckerstedt, K., Taskinen, E., Lautenschlager, I. Transpl. Int. (1997) [Pubmed]
  25. Factors controlling T-cell migration across rat cerebral endothelium in vitro. Pryce, G., Male, D., Campbell, I., Greenwood, J. J. Neuroimmunol. (1997) [Pubmed]
  26. Immunologic characterization of acute pancreatitis in rats induced by dibutyltin dichloride (DBTC). Hense, S., Sparmann, G., Weber, H., Liebe, S., Emmrich, J. Pancreas (2003) [Pubmed]
  27. Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array. Stocco, C., Callegari, E., Gibori, G. Endocrinology (2001) [Pubmed]
  28. Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats. Yin, X.J., Schafer, R., Ma, J.Y., Antonini, J.M., Roberts, J.R., Weissman, D.N., Siegel, P.D., Ma, J.K. Environ. Health Perspect. (2003) [Pubmed]
  29. Immunospecific suppression of encephalitogenic-activated T lymphocytes by chimeric cytotoxin IL-2-PE40. Beraud, E., Lorberboum-Galski, H., Chan, C.C., FitzGerald, D., Pastan, I., Nussenblatt, R.B. Cell. Immunol. (1991) [Pubmed]
  30. DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response. Mimran, A., Mor, F., Carmi, P., Quintana, F.J., Rotter, V., Cohen, I.R. J. Clin. Invest. (2004) [Pubmed]
  31. Synergy between cyclosporine and anti-IL-2 receptor monoclonal antibodies in rats. Functional studies of heart and kidney allografts. Ueda, H., Cheung, Y.C., Masetti, P., Diaco, M., McCarter, M., Kupiec-Weglinski, J.W., Tilney, N.L., Martin, M. Transplantation (1991) [Pubmed]
  32. The correlation of intragraft cytokine expression with rejection in rat small intestine transplantation. McDiarmid, S.V., Farmer, D.G., Kuniyoshi, J.S., Robert, M., Khadavi, A., Shaked, A., Busuttil, R.W. Transplantation (1994) [Pubmed]
  33. Four interleukin-2 surface binding proteins detected in rat spleen cells. Chopra, R.K., Carroll, M.P., May, W.S., Bhatia, S.K., Margolick, J.B., Nagel, J.E., Adler, W.H. Immunology (1992) [Pubmed]
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