The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Shbg  -  sex hormone binding globulin

Rattus norvegicus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Shbg

  • Shbg is thus a candidate for Hd, comprising autopodium (hand and foot) reduction and male sterility resulting from spermatogenesis impairment [1].
  • It is known that sex hormone-binding globulin (SHBG), which binds both testosterone and estradiol in human serum, is markedly elevated in cirrhosis [2].
  • Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in Escherichia coli [3].
  • Thirty postmenopausal women (11 omnivores, 10 vegetarians and 9 apparently healthy women with surgically removed breast cancer) were investigated with regard to the association of their urinary excretion of estrogens, lignans and isoflavonoids (all diphenols) with plasma sex hormone binding globulin (SHBG) [4].
  • SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin all significantly increased female sexual receptivity over vehicle or estradiol plus oxytocin infused controls, as measured by lordosis quotients and receptivity scores, at 40, and 90 min after their infusions into the medial preoptic area [5].

High impact information on Shbg


Chemical compound and disease context of Shbg


Biological context of Shbg


Anatomical context of Shbg


Associations of Shbg with chemical compounds

  • That in vivo estradiol treatments had the same inhibitory effects on mRNA levels for SHBG and both ERs suggests similar translational control mechanisms for all three steroid-binding proteins in the brain [12].
  • The results are compatible with the influx of albumin-bound E2 into all three tissues and the influx of sex hormone-binding globulin-bound E2 into the liver [17].
  • Fasting serum concentrations of 17-hydroxyprogesterone (17-OHP), androstenedione, testosterone, estrone, estradiol, and sex hormone-binding globulin were determined as possible endocrine correlates of LH isotypes [18].
  • Subsequently, tubules were perfused with ACF or ACF containing physiological concentrations of sex hormone-binding globulin (SHBG; an androgen-binding protein [ABP] homolog), 5 alpha-dihydrotestosterone (DHT), or SHBG+DHT.(ABSTRACT TRUNCATED AT 250 WORDS)[19]
  • The present studies assess the effects of human sex hormone-binding globulin (SHBG) on the conversion of [3H]testosterone (T) into dihydrotestosterone (DHT) in rat ventral prostate gland in vivo using a constant aortic infusion technique [20].

Other interactions of Shbg


Analytical, diagnostic and therapeutic context of Shbg

  • However, RT-PCR analysis revealed a significantly higher level of the Shbg transcript in hypodactylous rats compared to SHR controls [1].
  • Moreover, linkage mapping of Hd revealed that an intragenic marker for Shbg, D10Wox12, was non-recombinant with Hd [1].
  • We conclude that the presence of 4% HSA in the perfusion medium increases the biologic activity of estradiol and estrone on the isolated rat liver, and this increase is inhibited in the presence of sex hormone-binding globulin [23].
  • Isoelectric focusing in gel slabs allows rapid separation (1.5 hr) of receptors from other non-receptor proteins that bind steroid hormones, such as transcortin and sex hormone-binding globulin [24].
  • IN SITU hybridization showed increased SHBG mRNA signal during late pregnancy [25].


  1. Molecular analysis of the sex hormone-binding globulin gene in the rat hypodactylous mutation (Hd). Liska, F., Gösele, C., Kren, V., Hübner, N., Krenová, D. Folia Biol. (Praha) (2004) [Pubmed]
  2. Effects of human cirrhotic serum on estradiol and testosterone transport into rat brain. Sakiyama, R., Pardridge, W.M., Judd, H.L. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  3. Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in Escherichia coli. Lee, W.M., Wong, A.S., Tu, A.W., Cheung, C.H., Li, J.C., Hammond, G.L. J. Endocrinol. (1997) [Pubmed]
  4. Dietary phytoestrogens and cancer: in vitro and in vivo studies. Adlercreutz, H., Mousavi, Y., Clark, J., Höckerstedt, K., Hämäläinen, E., Wähälä, K., Mäkelä, T., Hase, T. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  5. Sex hormone binding globulin stimulates female sexual receptivity. Caldwell, J.D., Moe, B.D., Hoang, J., Nguyen, T. Brain Res. (2000) [Pubmed]
  6. Rat androgen-binding protein: evidence for identical subunits and amino acid sequence homology with human sex hormone-binding globulin. Joseph, D.R., Hall, S.H., French, F.S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter. Jänne, M., Hammond, G.L. J. Biol. Chem. (1998) [Pubmed]
  8. Mutagenesis of essential functional residues of rat androgen-binding protein/sex hormone-binding globulin. Joseph, D.R., Lawrence, W. Mol. Endocrinol. (1993) [Pubmed]
  9. Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function. Sullivan, P.M., Wang, Y.M., Joseph, D.R. Mol. Endocrinol. (1993) [Pubmed]
  10. The role of asparagine-linked oligosaccharides in the subunit structure, steroid binding, and secretion of androgen-binding protein. Joseph, D.R., Lawrence, W., Danzo, B.J. Mol. Endocrinol. (1992) [Pubmed]
  11. The pituitary-gonadal axis in experimental nephrotic syndrome in male rats. Elias, A.N., Carreon, G., Vaziri, N.D., Pandian, M.R., Oveisi, F. J. Lab. Clin. Med. (1992) [Pubmed]
  12. Estradiol control of expression and levels of estradiol-binding proteins in the medial preoptic area, medial hypothalamus and pituitary. Gao, G., Herbert, Z., Kong, J., Gabrielson, N., Mautz, A., Wu, D., Jirikowski, G.F., Caldwell, J.D. Neuroendocrinology (2003) [Pubmed]
  13. Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in women with cycle abnormalities, with or without polycystic ovarian disease. Fauser, B.C., Pache, T.D., Lamberts, S.W., Hop, W.C., de Jong, F.H., Dahl, K.D. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  14. The rabbit sex hormone-binding globulin gene: structural organization and characterization of its 5-flanking region. Ip, Y.C., Lee, W.M., Hammond, G.L. Endocrinology (2000) [Pubmed]
  15. Overexpression of androgen-binding protein/sex hormone-binding globulin in male transgenic mice: tissue distribution and phenotypic disorders. Joseph, D.R., O'Brien, D.A., Sullivan, P.M., Becchis, M., Tsuruta, J.K., Petrusz, P. Biol. Reprod. (1997) [Pubmed]
  16. Serum bioavailability and tissue metabolism of testosterone and estradiol in rat salivary gland. Cefalu, W.T., Pardridge, W.M., Chaudhuri, G., Judd, H.L. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  17. The effect of membrane permeability and binding by human serum proteins on sex steroid influx into the uterus. Laufer, L.R., Gambone, J.C., Chaudhuri, G., Pardridge, W.M., Judd, H.L. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  18. A preponderance of basic luteinizing hormone (LH) isoforms accompanies inappropriate hypersecretion of both basal and pulsatile LH in adolescents with polycystic ovarian syndrome. Ropelato, M.G., Garcia-Rudaz, M.C., Castro-Fernandez, C., Ulloa-Aguirre, A., Escobar, M.E., Barontini, M., Veldhuis, J.D. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  19. Protein synthesis and secretion by the rat caput epididymidis in vivo: influence of the luminal microenvironment. Turner, T.T., Miller, D.W., Avery, E.A. Biol. Reprod. (1995) [Pubmed]
  20. Reduction of testosterone availability to 5 alpha-reductase by human sex hormone-binding globulin in the rat ventral prostate gland in vivo. Ellison, S.A., Pardridge, W.M. Prostate (1990) [Pubmed]
  21. Sex hormone binding globulin facilitates female sexual receptivity except when coupled to dihydrotestosterone. Caldwell, J.D., Höfle, S., Englöf, I. Brain Res. (2002) [Pubmed]
  22. [7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer. Garg, P.K., Labaree, D.C., Hoyte, R.M., Hochberg, R.B. Nucl. Med. Biol. (2001) [Pubmed]
  23. Effects of serum proteins on estrogen action in the perfused rat liver. Reilly, J., Sadowski, S., Wolfe, T., Longcope, C. Steroids (1990) [Pubmed]
  24. Isoelectric focusing of steroid hormone receptors in slabs of polyacrylamide gel. Wrange, O. Breast Cancer Res. Treat. (1983) [Pubmed]
  25. Changes of sex hormone-binding globulin/SHBG expression in the hypothalamo-hypophyseal system of rats during pregnancy, parturition and lactation. Sendemir, E., Herbert, Z., Caldwell, J.D., Jirikowski, G.F. Horm. Metab. Res. (2006) [Pubmed]
WikiGenes - Universities