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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Brain Infarction

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Disease relevance of Brain Infarction


Psychiatry related information on Brain Infarction


High impact information on Brain Infarction


Chemical compound and disease context of Brain Infarction


Biological context of Brain Infarction


Anatomical context of Brain Infarction


Gene context of Brain Infarction

  • To better understand the interaction of pro- and antiinflammatory acute phase processes in brain infarction, plasma levels of IL-1RA, IL-6, and acute phase proteins including fibrinogen and c-reactive protein (CRP) were measured within 4 +/- 2 days of onset in 50 patients with acute ischemic stroke and in 20 age-matched healthy controls [27].
  • The ischaemic leukoaraiosis group had a different endothelial marker profile, with lower levels of TFPI (P = 0.01) and a higher TF/TFPI ratio (P = 0.01) compared with the isolated lacunar infarction group [28].
  • BACKGROUND AND PURPOSE: We initiated the present study to evaluate the clinical value of consecutive concentration determinations of S-100 and glial fibrillary acidic proteins in cerebrospinal fluid from patients with brain infarction [29].
  • The highest CA II concentrations were found in patients with brain infarction (median 66.5 micrograms L-1, n = 20), whereas the control patients had markedly lower values (median 7.8 micrograms L-1, n = 97) [30].
  • Well-characterized antisera were therefore used to examine the neuronal expression of CDK2, CDK4 and cyclins A, D1 and E in sections of brain from patients who had experienced cardiac arrest or focal brain infarction, and died 3.5 h to 9 days later [31].
  • Our results indicate that the SNP in the AGTRL1 gene is associated with the susceptibility to brain infarction [32].

Analytical, diagnostic and therapeutic context of Brain Infarction


  1. Complement activation in the central nervous system following blood-brain barrier damage in man. Lindsberg, P.J., Ohman, J., Lehto, T., Karjalainen-Lindsberg, M.L., Paetau, A., Wuorimaa, T., Carpén, O., Kaste, M., Meri, S. Ann. Neurol. (1996) [Pubmed]
  2. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Hassan, A., Hunt, B.J., O'Sullivan, M., Bell, R., D'Souza, R., Jeffery, S., Bamford, J.M., Markus, H.S. Brain (2004) [Pubmed]
  3. Automated measurement of infarct size with scanned images of triphenyltetrazolium chloride-stained rat brains. Goldlust, E.J., Paczynski, R.P., He, Y.Y., Hsu, C.Y., Goldberg, M.P. Stroke (1996) [Pubmed]
  4. Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Pedro-Botet, J., Sentí, M., Nogués, X., Rubiés-Prat, J., Roquer, J., D'Olhaberriague, L., Olivé, J. Stroke (1992) [Pubmed]
  5. Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells. Chen, Y., Hallenbeck, J.M., Ruetzler, C., Bol, D., Thomas, K., Berman, N.E., Vogel, S.N. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  6. Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy. Sabri, O., Ringelstein, E.B., Hellwig, D., Schneider, R., Schreckenberger, M., Kaiser, H.J., Mull, M., Buell, U. Stroke (1999) [Pubmed]
  7. Barbiturate-enhanced detection of brain lesions by carbon-14-labeled 2-deoxyglucose autoradiography. Frey, K.A., Agranoff, B.W. Science (1983) [Pubmed]
  8. Brain infarction and the clinical expression of Alzheimer disease. Mirra, S.S., Gearing, M. JAMA (1997) [Pubmed]
  9. Does ethanol intoxication promote brain infarction in young adults? Hillbom, M., Kaste, M. Lancet (1978) [Pubmed]
  10. Plasminogen activator inhibitor genotype and brain infarction. Elbaz, A., Cambien, F., Amarenco, P. Circulation (2001) [Pubmed]
  11. Renin-angiotensin-aldosterone system in brain infarction and vascular death. Brenner, D., Labreuche, J., Poirier, O., Cambien, F., Amarenco, P. Ann. Neurol. (2005) [Pubmed]
  12. The effect of postischemic blood glucose levels on ischemic brain damage in the rat. Voll, C.L., Auer, R.N. Ann. Neurol. (1988) [Pubmed]
  13. Cerebral ischemia and brain histamine. Adachi, N. Brain Res. Brain Res. Rev. (2005) [Pubmed]
  14. A phosphodiesterase inhibitor, cilostazol, prevents the onset of silent brain infarction in Japanese subjects with Type II diabetes. Shinoda-Tagawa, T., Yamasaki, Y., Yoshida, S., Kajimoto, Y., Tsujino, T., Hakui, N., Matsumoto, M., Hori, M. Diabetologia (2002) [Pubmed]
  15. Lacunar infarctions due to cholesterol emboli. Laloux, P., Brucher, J.M. Stroke (1991) [Pubmed]
  16. Cerebral blood flow in single and multiple lacunar infarctions. Mochizuki, Y., Oishi, M., Takasu, T. Stroke (1997) [Pubmed]
  17. Impairments of the protein C system and fibrinolysis in infection-associated stroke. Macko, R.F., Ameriso, S.F., Gruber, A., Griffin, J.H., Fernandez, J.A., Barndt, R., Quismorio, F.P., Weiner, J.M., Fisher, M. Stroke (1996) [Pubmed]
  18. Decrease in cerebral blood flow with blood pressure reductions in patients with chronic stroke. Mori, S., Sadoshima, S., Fujii, K., Ibayashi, S., Iino, K., Fujishima, M. Stroke (1993) [Pubmed]
  19. The transcription factor E2F1 modulates apoptosis of neurons. Hou, S.T., Callaghan, D., Fournier, M.C., Hill, I., Kang, L., Massie, B., Morley, P., Murray, C., Rasquinha, I., Slack, R., MacManus, J.P. J. Neurochem. (2000) [Pubmed]
  20. Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats. Choi, J.M., Shin, H.K., Kim, K.Y., Lee, J.H., Hong, K.W. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  21. Hydrogen ion buffering during complete brain ischemia. Kraig, R.P., Pulsinelli, W.A., Plum, F. Brain Res. (1985) [Pubmed]
  22. Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats. Martz, D., Rayos, G., Schielke, G.P., Betz, A.L. Stroke (1989) [Pubmed]
  23. Imaging of leukocytic infiltration in human cerebral infarcts. Pozzilli, C., Lenzi, G.L., Argentino, C., Carolei, A., Rasura, M., Signore, A., Bozzao, L., Pozzilli, P. Stroke (1985) [Pubmed]
  24. Neuropsychological correlates of a right unilateral lacunar thalamic infarction. Van Der Werf, Y.D., Weerts, J.G., Jolles, J., Witter, M.P., Lindeboom, J., Scheltens, P. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  25. Neuroprotection of naloxone against ischemic injury in rats: role of mu receptor antagonism. Liao, S.L., Chen, W.Y., Raung, S.L., Chen, C.J. Neurosci. Lett. (2003) [Pubmed]
  26. Reduced thrombomodulin in human peripheral nerve microvasculature. Hafer-Macko, C.E., Ivey, F.M., Gyure, K.A., Sorkin, J.D., Macko, R.F. Muscle Nerve (2002) [Pubmed]
  27. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Beamer, N.B., Coull, B.M., Clark, W.M., Hazel, J.S., Silberger, J.R. Ann. Neurol. (1995) [Pubmed]
  28. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Hassan, A., Hunt, B.J., O'Sullivan, M., Parmar, K., Bamford, J.M., Briley, D., Brown, M.M., Thomas, D.J., Markus, H.S. Brain (2003) [Pubmed]
  29. Determination of S-100 and glial fibrillary acidic protein concentrations in cerebrospinal fluid after brain infarction. Aurell, A., Rosengren, L.E., Karlsson, B., Olsson, J.E., Zbornikova, V., Haglid, K.G. Stroke (1991) [Pubmed]
  30. Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker. Parkkila, A.K., Parkkila, S., Reunanen, M., Niemelä, O., Tuisku, S., Rautakorpi, I., Rajaniemi, H. Eur. J. Clin. Invest. (1997) [Pubmed]
  31. Neuronal expression of cell cycle-related proteins after brain ischaemia in man. Love, S. Neurosci. Lett. (2003) [Pubmed]
  32. Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Hata, J., Matsuda, K., Ninomiya, T., Yonemoto, K., Matsushita, T., Ohnishi, Y., Saito, S., Kitazono, T., Ibayashi, S., Iida, M., Kiyohara, Y., Nakamura, Y., Kubo, M. Hum. Mol. Genet. (2007) [Pubmed]
  33. Single-photon emission computed tomography and early death in acute ischemic stroke. Limburg, M., van Royen, E.A., Hijdra, A., de Bruïne, J.F., Verbeeten, B.W. Stroke (1990) [Pubmed]
  34. Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice. Maeda, K., Hata, R., Hossmann, K.A. Neurobiol. Dis. (1999) [Pubmed]
  35. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. Gotti, B., Duverger, D., Bertin, J., Carter, C., Dupont, R., Frost, J., Gaudilliere, B., MacKenzie, E.T., Rousseau, J., Scatton, B. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  36. Association studies between haemochromatosis gene mutations and the risk of cardiovascular diseases. Hetet, G., Elbaz, A., Gariepy, J., Nicaud, V., Arveiler, D., Morrison, C., Kee, F., Evans, A., Simon, A., Amarenco, P., Cambien, F., Grandchamp, B. Eur. J. Clin. Invest. (2001) [Pubmed]
  37. Blood flow differences between leuko-araiosis with and without lacunar infarction. Oishi, M., Mochizuki, Y., Takasu, T. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1998) [Pubmed]
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