Disease relevance of ARIH1

• At 6 months, significant side effects occurred in the group treated with 0.75 mg/kg of prednisone, including weight gain, cushingoid appearance, and excessive hari growth [1].
• The Pakistan program for control of acute respiratory tract infections (ARIs) adopted the standard ARI-case-management strategy of the World Health Organization and recommended co-trimoxazole for the management of nonsevere pneumonia [2].
• Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications [3].
• The study of the resistive index (RI), difference of the RI (ARI) associated with a DDU intravesical recording (ureteral jets) were compared with renographic findings in renal colic [4].
• The ARI preparation may, therefore, contain an "internal image" anti-idiotype causing thyroid (Ab2) stimulation, a Graves' disease specific anti-idiotype whose binding with Ab2 inhibits its ability to bind TSH and anti-anti-idiotype (Ab3) to "internal image" Ab2 [5].

High impact information on ARIH1

• This is not a general phenomenon as there is an absence of similar inclusions when HHARI, a structural homolog of Parkin, is overexpressed [6].
• We now demonstrate that HHARI interacts and co-localizes with UbcH7 in mammalian cells, particularly in the perinuclear region [7].
• The radiographic manifestations of Hari, a peculiar type of acupuncture currently practiced in Japan, are described [8].
• Co-trimoxazole is still recommended by the Pakistan ARI control program [2].
• Hari and Renvall (Trends Cogn. Sci., 5 (2001) 525) proposed that dyslexic children suffer from sluggish attention deployment due to a right parietal lobe dysfunction [9].

Chemical compound and disease context of ARIH1

• These findings indicated that sorbitol itself and/or secondary sodium accumulation caused by an increase in sorbitol may be a major contributor to the increase in intracellular hydration and prolonged relaxation times associated with hyperglycemia, which are reversible with insulin or ARI treatment [10].
• Based on one large trial, ASA taken for 5 years reduced myocardial infarction (ARR, 0.5%, NNT 200 for 5 years), increased major haemorrhage (ARI, 0.7%, NNT 154), and did not reduce all cause mortality or cardiovascular mortality [11].
• Undernutrition, vitamin A deficiency and ARI morbidity in underfives [12].
• Accordingly, the effect of an aldose reductase inhibitor (ARI; Ponalrestat) on erythrocyte Na,K-ATPase activity was studied following two or three months oral administration in seven of the diabetic patients with polyneuropathy [13].

Biological context of ARIH1

• Sequencing of the ARIH1 PACs showed that the gene has 13 introns [14].
• Using these PACs as probes, we mapped ARIH1 to human chromosome 15q24 by fluorescence in situ hybridisation (FISH) [14].
• Human homologue of Drosophila ariadne (HHARI) is a RING-IBR-RING domain protein identified through its ability to bind the human ubiquitin-conjugating enzyme, UbcH7 [15].
• In rural Malawi, 703 newborns were visited monthly for 1 year to describe the epidemiology and health-seeking behaviour during acute episodes of diarrhoea, respiratory infections (ARI) and malaria [16].
• The anger-out x hostility interaction for diastolic blood pressure change during ARI was also significant such that high anger-out/low hostility patients showed the smallest changes [17].

Anatomical context of ARIH1

• The dose of ARI chosen for such studies has been based on the surrogate of erythrocyte aldose reductase activity confirmed by short-term studies on disease reversal.(ABSTRACT TRUNCATED AT 250 WORDS)[18]
• In the ascending loop of Henle, a reduced expression could be seen (ARI, p=0.015; and ARII, p=0.043) [19].
• TF staining of the brush border of renal transplants undergoing acute cyclosporin A (CsA) nephrotoxicity (n=18) was significantly higher than in normal kidneys (p=0.0003), as well as in transplants undergoing various degrees of acute rejection (ARI, p=0.027; ARII, p=0.0012; and ARIII, p=0.0001) [19].
• Peripheral nerve repair following ARI treatment [20].
• RESULTS: ARI values in the lesional and control (non-lesional adjacent) skin/mucosa were found to be 14.5 versus 18% for OU, 28.7 versus 25.5% for GU and 36.3 versus 21.8% (p = 0.068) for SPT areas [21].

Associations of ARIH1 with chemical compounds

• In addition, ARI stimulated thyroid cell cyclic AMP accumulation in both human and rat thyroid cells [5].
• Since ARI decreases glucose-mediated inhibition of NO production in HUVEC. this agent might ameliorate endothelial function associated with diabetes [22].
• Seven percent (90/1290) of the patients with normal pre-operative creatinine developed ARI [23].
• In the present study, the effects of non-enzymatic glycation of recombinant human AR (rhAR) on enzyme activity and affinity for its substrate (glyceraldehyde), co-factor (NADPH) and inhibitors (ARI; Sorbinil, Tolrestat, AL-1576 and Statil) were examined [24].
• Tested ARIs do not share the same efflux transporter with epalrestat, the only ARI currently on the market in Japan. The most permeable compound, a 2,6-difluoro-4-pyrrol-1ylphenol derivative, is not a substrate for efflux transporters and would therefore be the most promising lead compound for further investigation of potent ARIs [25].

Other interactions of ARIH1

• We recently reported the identification of a RING finger-containing protein, HHARI (human homologue of Drosophila ariadne), which binds to the human ubiquitin-conjugating enzyme UbcH7 in vitro [7].

Analytical, diagnostic and therapeutic context of ARIH1

• In the PtcO2 range between 40 and 100 torr, the ARI and ISI did not depend on the PtcO2 magnitude [26].
• Few therapeutic interventions currently exist to reverse HARI other than optimization of renal perfusion and limitation of nephrotoxin exposure [27].
• ARI potential of isolated tannoids of E. officinalis were also investigated against osmotic stress in rat lens organ culture [3].
• In the ARI study group the viral load was increased almost 2000-fold, suggesting acute infection in this group and former or latent infection in the COPD group [28].
• In the WHO/ARI Young Infant Multicentre Study we have found an ordinal outcome scale made up of a mixture of laboratory and diagnostic markers to have several clinical advantages as well as to increase the power of tests for risk factors [29].

References