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Gene Review

Vamp3  -  vesicle-associated membrane protein 3

Rattus norvegicus

Synonyms: CEB, Cellubrevin, Syb3, Synaptobrevin-3, VAMP-3, ...
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Disease relevance of Vamp3


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Chemical compound and disease context of Vamp3


Biological context of Vamp3


Anatomical context of Vamp3


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Analytical, diagnostic and therapeutic context of Vamp3


  1. Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. McMahon, H.T., Ushkaryov, Y.A., Edelmann, L., Link, E., Binz, T., Niemann, H., Jahn, R., Südhof, T.C. Nature (1993) [Pubmed]
  2. A targeting signal in VAMP regulating transport to synaptic vesicles. Grote, E., Hao, J.C., Bennett, M.K., Kelly, R.B. Cell (1995) [Pubmed]
  3. Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate. Bezzi, P., Gundersen, V., Galbete, J.L., Seifert, G., Steinhäuser, C., Pilati, E., Volterra, A. Nat. Neurosci. (2004) [Pubmed]
  4. Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles. Tong, P., Khayat, Z.A., Huang, C., Patel, N., Ueyama, A., Klip, A. J. Clin. Invest. (2001) [Pubmed]
  5. Proteolytic cleavage of cellubrevin and vesicle-associated membrane protein (VAMP) by tetanus toxin does not impair insulin-stimulated glucose transport or GLUT4 translocation in rat adipocytes. Hajduch, E., Aledo, J.C., Watts, C., Hundal, H.S. Biochem. J. (1997) [Pubmed]
  6. Cellubrevin and synaptobrevins: similar subcellular localization and biochemical properties in PC12 cells. Chilcote, T.J., Galli, T., Mundigl, O., Edelmann, L., McPherson, P.S., Takei, K., De Camilli, P. J. Cell Biol. (1995) [Pubmed]
  7. VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion. Regazzi, R., Wollheim, C.B., Lang, J., Theler, J.M., Rossetto, O., Montecucco, C., Sadoul, K., Weller, U., Palmer, M., Thorens, B. EMBO J. (1995) [Pubmed]
  8. Cultured glial cells express the SNAP-25 analogue SNAP-23. Hepp, R., Perraut, M., Chasserot-Golaz, S., Galli, T., Aunis, D., Langley, K., Grant, N.J. Glia (1999) [Pubmed]
  9. Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes. Verderio, C., Coco, S., Rossetto, O., Montecucco, C., Matteoli, M. J. Neurochem. (1999) [Pubmed]
  10. The vesicle-associated membrane protein family of proteins in rat pancreatic and parotid acinar cells. Gaisano, H.Y., Sheu, L., Grondin, G., Ghai, M., Bouquillon, A., Lowe, A., Beaudoin, A., Trimble, W.S. Gastroenterology (1996) [Pubmed]
  11. Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells. Arora, N., Williamson, L.C., Leppla, S.H., Halpern, J.L. J. Biol. Chem. (1994) [Pubmed]
  12. Expression of vesicle-associated membrane protein 2 (VAMP-2)/synaptobrevin II and cellubrevin in rat skeletal muscle and in a muscle cell line. Volchuk, A., Mitsumoto, Y., He, L., Liu, Z., Habermann, E., Trimble, W., Klip, A. Biochem. J. (1994) [Pubmed]
  13. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. Liu, L.B., Omata, W., Kojima, I., Shibata, H. J. Biol. Chem. (2003) [Pubmed]
  14. Exocytotic protein components in rat pituitary gland after long-term estrogen administration. Majó, G., Lorenzo, M.J., Blasi, J., Aguado, F. J. Endocrinol. (1999) [Pubmed]
  15. Cellubrevin is present in the basolateral endocytic compartment of hepatocytes and follows the transcytotic pathway after IgA internalization. Calvo, M., Pol, A., Lu, A., Ortega, D., Pons, M., Blasi, J., Enrich, C. J. Biol. Chem. (2000) [Pubmed]
  16. Synaptobrevin isoforms in secretory granules and synaptic-like microvesicles in anterior pituitary cells. Majó, G., Aguado, F., Blasi, J., Marsal, J. Life Sci. (1998) [Pubmed]
  17. Expression of syntaxin 4 in rat skeletal muscle and rat skeletal muscle cells in culture. Sumitani, S., Ramlal, T., Liu, Z., Klip, A. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  18. Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. Edelmann, L., Hanson, P.I., Chapman, E.R., Jahn, R. EMBO J. (1995) [Pubmed]
  19. Localization of cellubrevin to the Golgi complex in pancreatic acinar cells. Sengupta, D., Gumkowski, F.D., Tang, L.H., Chilcote, T.J., Jamieson, J.D. Eur. J. Cell Biol. (1996) [Pubmed]
  20. Water channel-carrying vesicles in the rat IMCD contain cellubrevin. Franki, N., Macaluso, F., Schubert, W., Gunther, L., Hays, R.M. Am. J. Physiol. (1995) [Pubmed]
  21. Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. Imai, A., Nashida, T., Yoshie, S., Shimomura, H. Arch. Oral Biol. (2003) [Pubmed]
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