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Gene Review

Vamp3  -  vesicle-associated membrane protein 3

Mus musculus

Synonyms: CEB, Cellubrevin, D130027G05Rik, Syb3, Synaptobrevin-3, ...
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Disease relevance of Vamp3


High impact information on Vamp3


Biological context of Vamp3


Anatomical context of Vamp3

  • In this work, we report that cellubrevin, a v-SNARE functioning in endosomal recycling and implicated in endosomal interactions with post-Golgi compartments, plays a role in phagosomal maturation and that it is altered on mycobacterial phagosomes [3].
  • Cellubrevin status on phagosomes had consequences on phagosomal membrane and lumenal content trafficking, involving plasma membrane marker recycling and delivery of lysosomal enzymes [3].
  • Cellubrevin was markedly induced during differentiation of 3T3-L1 fibroblasts into adipocytes, in parallel with GLUT4, and the development of insulin regulated traffic [10].
  • The beta cell lines were also shown to express a second vesicle (v)-SNARE, cellubrevin [11].
  • From these results we concluded that cellubrevin-dependent membrane trafficking is involved in TEX101-transport to the surface of male germ cells [9].

Associations of Vamp3 with chemical compounds


Other interactions of Vamp3

  • Immuno-EM on intracellular vesicles from adipocytes revealed that VAMP-2 was colocalized with GLUT-4, whereas only partial colocalization was observed between GLUT-4 and cellubrevin [5].
  • BoNT/B was shown by immunoblotting to cause extensive proteolysis of Cbr and Sbr resulting in a significant blockade of the insulin-stimulated translocation of GLUT4 to the plasmalemma [12].
  • Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present [12].
  • Levels of the v-SNARE protein cellubrevin and of the t-SNARE protein syntaxin 4 were increased in this process in parallel to GLUT4 [13].
  • Regardless of the phagocytic receptor engaged or particle load, BMM lacking vamp3 exhibited no phagocytic defects when assayed after 1 h at 37 degrees C, and phagosome maturation was unimpaired as judged by acquisition of lamp-1 [8].

Analytical, diagnostic and therapeutic context of Vamp3


  1. Endobrevin/VAMP-8 Is the Primary v-SNARE for the Platelet Release Reaction. Ren, Q., Barber, H.K., Crawford, G.L., Karim, Z.A., Zhao, C., Choi, W., Wang, C.C., Hong, W., Whiteheart, S.W. Mol. Biol. Cell (2007) [Pubmed]
  2. VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking. Yang, C., Mora, S., Ryder, J.W., Coker, K.J., Hansen, P., Allen, L.A., Pessin, J.E. Mol. Cell. Biol. (2001) [Pubmed]
  3. Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest. Fratti, R.A., Chua, J., Deretic, V. J. Biol. Chem. (2002) [Pubmed]
  4. v-SNAREs control exocytosis of vesicles from priming to fusion. Borisovska, M., Zhao, Y., Tsytsyura, Y., Glyvuk, N., Takamori, S., Matti, U., Rettig, J., Südhof, T., Bruns, D. EMBO J. (2005) [Pubmed]
  5. The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells. Martin, S., Tellam, J., Livingstone, C., Slot, J.W., Gould, G.W., James, D.E. J. Cell Biol. (1996) [Pubmed]
  6. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. Haass, N.K., Kartenbeck, M.A., Leube, R.E. J. Cell Biol. (1996) [Pubmed]
  7. Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion. Proux-Gillardeaux, V., Gavard, J., Irinopoulou, T., Mège, R.M., Galli, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Rate and extent of phagocytosis in macrophages lacking vamp3. Allen, L.A., Yang, C., Pessin, J.E. J. Leukoc. Biol. (2002) [Pubmed]
  9. Testicular proteins associated with the germ cell-marker, TEX101: involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis. Tsukamoto, H., Yoshitake, H., Mori, M., Yanagida, M., Takamori, K., Ogawa, H., Takizawa, T., Araki, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  10. Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes. Volchuk, A., Sargeant, R., Sumitani, S., Liu, Z., He, L., Klip, A. J. Biol. Chem. (1995) [Pubmed]
  11. Characterization of SNARE protein expression in beta cell lines and pancreatic islets. Wheeler, M.B., Sheu, L., Ghai, M., Bouquillon, A., Grondin, G., Weller, U., Beaudoin, A.R., Bennett, M.K., Trimble, W.S., Gaisano, H.Y. Endocrinology (1996) [Pubmed]
  12. Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present. Chen, F., Foran, P., Shone, C.C., Foster, K.A., Melling, J., Dolly, J.O. Biochemistry (1997) [Pubmed]
  13. SNARE expression and distribution during 3T3-L1 adipocyte differentiation. Torrejón-Escribano, B., Gómez de Aranda, I., Blasi, J. FEBS Lett. (2002) [Pubmed]
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