Disease relevance of Ptpn5

• RESULTS Step-serial sections of the cavernosal nerve revealed numerous ganglion cells in the initial segments and gradually fewer myelinated fibres at distal levels [1].

Psychiatry related information on Ptpn5

• Rhodiolae roseae on the memory-impairing action of convulsant electroshock. "Step-down" passive avoidance training with negative reinforcement was used to trace the changes in memory [2].

High impact information on Ptpn5

• In crude cytosols these two steps would presumably occur simultaneously, and addition of Na2MoO4 prior to warming would block Step 1 and hence Step 2 would not occur [3].
• We showed previously that fibril formation in vitro from rat tail tendon collagen requires a temperature-dependent initiation (Step 1) following which linear assembly to form thin filaments (Step 2) proceeds as rapidly at 4 degrees C as at 26 degrees C. Step 3, lateral assembly of filaments to form fibrils, is again temperature-dependent [4].
• RESULTS: Step increases in perfusion pressure (PP; from 10 to 140 mmHg) elicited significantly greater constrictions in DM than in C gracilis arterioles, in the presence of the endothelium (E) [5].
• 3. Step depolarizations from the holding potential of -80 mV evoked a transient (< 100 ms at -40 mV) outward K+ current (IA) which was blocked by 4-aminopyridine (4-AP, 1 mM) [6].
• 5. 4. Step changes in holding potential resulted in shifts in chloride equilibrium potential (ECl), as determined by time-dependent changes in the size of GABA-induced currents [7].

Biological context of Ptpn5

• RESULTS: Step increases in extracellular [Ca2+] concentration (0-10 mM) in high K+ (40 mM)-depolarized smooth muscle produced incremental increases in [Ca2+]i, MLC phosphorylation, and contraction [8].
• Round spermatids differentiated to Step 7 of spermiogenesis but Step 16 spermatids failed to develop [9].
• Examination of longitudinal sections through Stages XIII, XIV and I were useful for comparing cells from Meiotic divisions (meta-, ana-, and telophases) I and II and also for differentiating secondary spermatocytes from Step 1 spermatids [10].

Anatomical context of Ptpn5

• After CD treatment, a 5.8-fold increase in malorientation of Step 8 spermatids was noted [11].
• It is suggested that reduced testosterone is associated with a mid-spermiogenic lesion interfering with stable attachment of Step 8-9 spermatids to Sertoli cells during Stage VIII-IX of the spermatogenic cycle [12].
• Spermatids at Step 8 of development are known to become oriented with their acrosomes facing the base of the Sertoli cell [11].
• Leptotene/zygotene spermatocytes and Step 1 spermatids also showed degenerative changes but only after prolonged dosing at high-dose levels [13].
• Histologic changes in the testis included retention of Step 19 spermatids in Stages IX to XII, abnormal development of late spermatids, and the formation of atypical structures resembling residual bodies that were observed predominantly in Stages X to XIV and I of the cycle of the seminiferous epithelium [14].

Associations of Ptpn5 with chemical compounds

• On day 16 distorted sperm heads were recognized in Step 12, and older spermatids, and luminal cytoplasmic debris was found throughout the epididymis [15].
• METHODS: Step-down type passive avoidance test, shuttle-box test, and Morris water maze were used together to determine effects of Abeta25-35 and melatonin on learning and memory [16].
• Rat testicular tissue, perfused with glutaraldehyde, post-fixed with osmium and stained with toluidine blue, was studied to obtain information which could be used to characterize spermatocytes (also type B gonia and Step 1 spermatids) with the light microscope [10].

Analytical, diagnostic and therapeutic context of Ptpn5

• At 1 and 2 weeks after treatment, Step 8-9 spermatids were partially or completely detached from Sertoli cells [12].
• Finally, it is shown how the islet isograft can be excised from the nephrectomy specimen and "recycled" into another diabetic rat (Step 2) [17].

References