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Gene Review

HOXA5  -  homeobox A5

Homo sapiens

Synonyms: HOX1, HOX1.3, HOX1C, Homeobox protein Hox-1C, Homeobox protein Hox-A5
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Disease relevance of HOXA5


High impact information on HOXA5

  • Transient transfection of Hox/HOXA5 activated the p53 promoter [5].
  • We conclude that loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5 [5].
  • The HOXA5 promoter region was methylated in 16 out of 20 p53-negative breast tumour specimens [5].
  • Additionally, we provide evidence that hDOT1L has an important role in the transformation process. hDOT1L contributes to CALM-AF10-mediated leukaemic transformation by preventing nuclear export of CALM-AF10 and by upregulating the Hoxa5 gene through H3K79 methylation [6].
  • Further, several small interfering RNAs which specifically silenced caspase 2 and caspase 8 expression significantly blocked HOXA5-induced apoptosis [7].

Biological context of HOXA5


Anatomical context of HOXA5


Associations of HOXA5 with chemical compounds


Physical interactions of HOXA5


Regulatory relationships of HOXA5


Other interactions of HOXA5


Analytical, diagnostic and therapeutic context of HOXA5

  • Western blot analysis further confirmed that caspases 2 and 8 were activated after the induction of HOXA5 expression [7].
  • Promoter deletion, chromatin immunoprecipitation assay, and gel-shift assays were performed to show that HOXA5 can directly bind to one binding site on the pleiotrophin promoter [16].
  • These data strongly suggest that microarray analysis can successfully identify many potential direct downstream genes of HOXA5 [16].
  • In order to decipher downstream signaling pathways of HOXA5, we utilized oligonucleotide microarray analysis to identify genes that are differentially expressed in HOXA5-induced cells compared with uninduced cells [16].
  • Identification and linkage mapping of the genes for the putative homeodomain protein (hox1) and the putative pheromone receptor protein homologue (rcb1) in a bipolar basidiomycete, Pholiota nameko [17].


  1. HOXA5-twist interaction alters p53 homeostasis in breast cancer cells. Stasinopoulos, I.A., Mironchik, Y., Raman, A., Wildes, F., Winnard, P., Raman, V. J. Biol. Chem. (2005) [Pubmed]
  2. HOXA5 regulates expression of the progesterone receptor. Raman, V., Tamori, A., Vali, M., Zeller, K., Korz, D., Sukumar, S. J. Biol. Chem. (2000) [Pubmed]
  3. Disordered expression of HOX genes in human non-small cell lung cancer. Abe, M., Hamada, J., Takahashi, O., Takahashi, Y., Tada, M., Miyamoto, M., Morikawa, T., Kondo, S., Moriuchi, T. Oncol. Rep. (2006) [Pubmed]
  4. Heme oxygenase-1 polymorphism associated with severity of chronic obstructive pulmonary disease. Fu, W.P., Zhao, Z.H., Fang, L.Z., Sun, C., Liu, L., Zhang, J.Q., Zhang, Y.P., Dai, L.M. Chin. Med. J. (2007) [Pubmed]
  5. Compromised HOXA5 function can limit p53 expression in human breast tumours. Raman, V., Martensen, S.A., Reisman, D., Evron, E., Odenwald, W.F., Jaffee, E., Marks, J., Sukumar, S. Nature (2000) [Pubmed]
  6. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Okada, Y., Jiang, Q., Lemieux, M., Jeannotte, L., Su, L., Zhang, Y. Nat. Cell Biol. (2006) [Pubmed]
  7. HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. Chen, H., Chung, S., Sukumar, S. Mol. Cell. Biol. (2004) [Pubmed]
  8. HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. Golpon, H.A., Geraci, M.W., Moore, M.D., Miller, H.L., Miller, G.J., Tuder, R.M., Voelkel, N.F. Am. J. Pathol. (2001) [Pubmed]
  9. Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. Crooks, G.M., Fuller, J., Petersen, D., Izadi, P., Malik, P., Pattengale, P.K., Kohn, D.B., Gasson, J.C. Blood (1999) [Pubmed]
  10. Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. La Celle, P.T., Polakowska, R.R. J. Biol. Chem. (2001) [Pubmed]
  11. Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma. Wang, X.F., Qian, D.Z., Ren, M., Kato, Y., Wei, Y., Zhang, L., Fansler, Z., Clark, D., Nakanishi, O., Pili, R. Clin. Cancer Res. (2005) [Pubmed]
  12. Fetal lung mRNA levels of Hox genes are differentially altered by maternal diabetes and butyrate in rats. Jacobs, H.C., Bogue, C.W., Pinter, E., Wilson, C.M., Warshaw, J.B., Gross, I. Pediatr. Res. (1998) [Pubmed]
  13. HOXA5 regulates hMLH1 expression in breast cancer cells. Duriseti, S., Winnard, P.T., Mironchik, Y., Vesuna, F., Raman, A., Raman, V. Neoplasia (2006) [Pubmed]
  14. Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. Henderson, G.S., van Diest, P.J., Burger, H., Russo, J., Raman, V. Cell. Oncol. (2006) [Pubmed]
  15. HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. Stelnicki, E.J., Kömüves, L.G., Kwong, A.O., Holmes, D., Klein, P., Rozenfeld, S., Lawrence, H.J., Adzick, N.S., Harrison, M., Largman, C. J. Invest. Dermatol. (1998) [Pubmed]
  16. Identification of transcriptional targets of HOXA5. Chen, H., Rubin, E., Zhang, H., Chung, S., Jie, C.C., Garrett, E., Biswal, S., Sukumar, S. J. Biol. Chem. (2005) [Pubmed]
  17. Identification and linkage mapping of the genes for the putative homeodomain protein (hox1) and the putative pheromone receptor protein homologue (rcb1) in a bipolar basidiomycete, Pholiota nameko. Aimi, T., Yoshida, R., Ishikawa, M., Bao, D., Kitamoto, Y. Curr. Genet. (2005) [Pubmed]
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