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Gene Review

KTN1  -  kinectin 1 (kinesin receptor)

Homo sapiens

Synonyms: CG-1 antigen, CG1, KIAA0004, KNT, Kinectin, ...
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Disease relevance of KTN1


High impact information on KTN1

  • This antibody bound to the cytoplasmic domain of kinectin, an integral membrane protein of the endoplasmic reticulum that binds to kinesin [5].
  • In this article, Janis Burkhardt discusses the evidence that the protein kinectin serves as a membrane receptor for kinesin, and describes how motor-receptor proteins may interact with other components of the motility machinery to generate regulated movement of membrane organelles [6].
  • When cells were injected with CG1 or Fab fragments of CG1, fixed, and counter-stained with rabbit antibodies to reveal the microtubule, microfilament, and intermediate filament systems, no obvious differences from the patterns normally seen in uninjected cells were observed [7].
  • In the present study, we used SSCP analysis to evaluate a series of patients belonging to CG1 for mutations in PEX1 and studied phenotype-genotype correlations [8].
  • These results suggest that kinectin may be a candidate autoantigen that is involved in the pathophysiology of AA [1].

Biological context of KTN1


Anatomical context of KTN1


Associations of KTN1 with chemical compounds

  • Integrin clustering induces kinectin accumulation [17].
  • CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif [18].
  • Treatment of cells with diverse apoptotic stimuli including TNF, anti-Fas, anticancer drugs, gamma-radiation or ceramide leads to rapid proteolytic cleavage of the 160-kDa form of kinectin to a 120-kDa fragment [19].

Physical interactions of KTN1

  • The minimal EF-1 delta-binding domain on kinectin resides within a conserved region present in all the kinectin isoforms [20].
  • The kinectin-binding domain on the kinesin tail partially overlaps its head-binding domain and the myosin-Va binding domain [16].

Other interactions of KTN1


Analytical, diagnostic and therapeutic context of KTN1


  1. Autoantibodies frequently detected in patients with aplastic anemia. Hirano, N., Butler, M.O., Von Bergwelt-Baildon, M.S., Maecker, B., Schultze, J.L., O'Connor, K.C., Schur, P.H., Kojima, S., Guinan, E.C., Nadler, L.M. Blood (2003) [Pubmed]
  2. Establishment and characterization of a tumor cell line from human nasopharyngeal carcinoma tissue. Chang, Y.S., Lin, S.Y., Lee, P.F., Durff, T., Chung, H.C., Tsai, M.S. Cancer Res. (1989) [Pubmed]
  3. Comparison of antitumor activity of vitamins K1, K2 and K3 on human tumor cells by two (MTT and SRB) cell viability assays. Wu, F.Y., Liao, W.C., Chang, H.M. Life Sci. (1993) [Pubmed]
  4. Electron microscopic observation of established chondrocytes derived from human intervertebral disc hernia (KTN-1) and role of macrophages in spontaneous regression of degenerated tissues. Tsuru, M., Nagata, K., Ueno, T., Jimi, A., Irie, K., Yamada, A., Nishida, T., Sata, M. The spine journal : official journal of the North American Spine Society. (2001) [Pubmed]
  5. Kinectin, an essential anchor for kinesin-driven vesicle motility. Kumar, J., Yu, H., Sheetz, M.P. Science (1995) [Pubmed]
  6. In search of membrane receptors for microtubule-based motors - is kinectin a kinesin receptor? Burkhardt, J.K. Trends Cell Biol. (1996) [Pubmed]
  7. Probing the role of nonmuscle tropomyosin isoforms in intracellular granule movement by microinjection of monoclonal antibodies. Hegmann, T.E., Lin, J.L., Lin, J.J. J. Cell Biol. (1989) [Pubmed]
  8. Disorders of peroxisome biogenesis due to mutations in PEX1: phenotypes and PEX1 protein levels. Walter, C., Gootjes, J., Mooijer, P.A., Portsteffen, H., Klein, C., Waterham, H.R., Barth, P.G., Epplen, J.T., Kunau, W.H., Wanders, R.J., Dodt, G. Am. J. Hum. Genet. (2001) [Pubmed]
  9. Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma. Salassidis, K., Bruch, J., Zitzelsberger, H., Lengfelder, E., Kellerer, A.M., Bauchinger, M. Cancer Res. (2000) [Pubmed]
  10. Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. Yu, H., Nicchitta, C.V., Kumar, J., Becker, M., Toyoshima, I., Sheetz, M.P. Mol. Biol. Cell (1995) [Pubmed]
  11. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. Alberts, A.S., Bouquin, N., Johnston, L.H., Treisman, R. J. Biol. Chem. (1998) [Pubmed]
  12. Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes. Vancoillie, G., Lambert, J., Mulder, A., Koerten, H.K., Mommaas, A.M., Van Oostveldt, P., Naeyaert, J.M. J. Invest. Dermatol. (2000) [Pubmed]
  13. The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22. Print, C.G., Morris, C.M., Spurr, N.K., Rooke, L., Krissansen, G.W. Immunogenetics (1996) [Pubmed]
  14. Kinectin is a key effector of RhoG microtubule-dependent cellular activity. Vignal, E., Blangy, A., Martin, M., Gauthier-Rouvière, C., Fort, P. Mol. Cell. Biol. (2001) [Pubmed]
  15. Molecular cloning and characterization of human kinectin. Fütterer, A., Kruppa, G., Krämer, B., Lemke, H., Krönke, M. Mol. Biol. Cell (1995) [Pubmed]
  16. Kinectin-kinesin binding domains and their effects on organelle motility. Ong, L.L., Lim, A.P., Er, C.P., Kuznetsov, S.A., Yu, H. J. Biol. Chem. (2000) [Pubmed]
  17. Integrin clustering induces kinectin accumulation. Tran, H., Pankov, R., Tran, S.D., Hampton, B., Burgess, W.H., Yamada, K.M. J. Cell. Sci. (2002) [Pubmed]
  18. A smart magnetic resonance contrast agent for selective copper sensing. Que, E.L., Chang, C.J. J. Am. Chem. Soc. (2006) [Pubmed]
  19. Caspase 7-induced cleavage of kinectin in apoptotic cells. Machleidt, T., Geller, P., Schwandner, R., Scherer, G., Krönke, M. FEBS Lett. (1998) [Pubmed]
  20. Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum. Ong, L.L., Er, C.P., Ho, A., Aung, M.T., Yu, H. J. Biol. Chem. (2003) [Pubmed]
  21. Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats. Print, C.G., Leung, E., Harrison, J.E., Watson, J.D., Krissansen, G.W. Gene (1994) [Pubmed]
  22. Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization. Rao, P.N., Yu, H., Hodge, R., Pettenati, M.J., Sheetz, M.P. Cytogenet. Cell Genet. (1997) [Pubmed]
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