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Gene Review

TBXAS1  -  thromboxane A synthase 1 (platelet)

Sus scrofa

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Disease relevance of TBXAS1


High impact information on TBXAS1


Chemical compound and disease context of TBXAS1


Biological context of TBXAS1


Anatomical context of TBXAS1


Associations of TBXAS1 with chemical compounds

  • Sequence comparison among porcine (p), human (h), and murine (m) TS indicated conservation of eight Cys residues and one putative N-glycosylation site [13].
  • Thromboxane synthase was irreversibly inactivated by 15-hydroxy-9 alpha, 11 alpha-peroxidoprosta-5,13-dienoic acid during catalysis and by treatment of 15-hydroperoxyeicosatetraenoic acid [9].
  • The protective effects of DMTU in GBS-treated piglets could not be ascribed to inhibition of cyclooxygenase or thromboxane synthase because the oxygen radical scavenger failed to attenuate increases in pulmonary arterial pressure and venous thromboxane B2 content or reductions in arterial PO2 caused by i.v. infusions of arachidonic acid [18].
  • Endothelial nitric oxide synthase (eNOS), cyclooxygenase-1, cyclooxygenase-2, prostacyclin synthase, and thromboxane synthase amounts were unaltered in all lung tissue homogenates [19].
  • Antagonists of prostaglandins (SC 19220) or leukotrienes (FPL 55712) also diminished the inherent tone, whereas an inhibitor of thromboxane synthase (OKY 046) had no significant effect [20].

Analytical, diagnostic and therapeutic context of TBXAS1


  1. N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents. Tilley, J.W., Levitan, P., Lind, J., Welton, A.F., Crowley, H.J., Tobias, L.D., O'Donnell, M. J. Med. Chem. (1987) [Pubmed]
  2. Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism. Ghuysen, A., Lambermont, B., Dogné, J.M., Kolh, P., Tchana-Sato, V., Morimont, P., Magis, D., Hanson, J., Segers, P., D'Orio, V. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  3. Intrinsic microbicidal activity and pulmonary hypertension in isolated newborn piglet lungs. Aziz, S.M., Pauly, T.H., Gillespie, M.N. Pediatr. Res. (1993) [Pubmed]
  4. BM-573, a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, prevents pig myocardial infarction induced by coronary thrombosis. Rolin, S., Petein, M., Tchana-Sato, V., Dogne, J.M., Benoit, P., Lambermont, B., Ghuysen, A., Kolh, P., Masereel, B. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  5. Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets. Fike, C.D., Zhang, Y., Kaplowitz, M.R. J. Appl. Physiol. (2005) [Pubmed]
  6. Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia. Parker, J.L., Adams, H.R. Circ. Res. (1993) [Pubmed]
  7. Effect of endogenously produced leukotrienes and thromboxane on renal vascular resistance in rabbit hydronephrosis. Albrightson, C.R., Evers, A.S., Griffin, A.C., Needleman, P. Circ. Res. (1987) [Pubmed]
  8. Monoclonal antibodies to thromboxane synthase from porcine lung. Production and application to development of a tandem immunoradiometric assay. Shen, R.F., Tai, H.H. J. Biol. Chem. (1986) [Pubmed]
  9. Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. Shen, R.F., Tai, H.H. J. Biol. Chem. (1986) [Pubmed]
  10. Alpha-thrombin-induced pulmonary vasoconstriction. Horgan, M.J., Fenton, J.W., Malik, A.B. J. Appl. Physiol. (1987) [Pubmed]
  11. Effects of the combined thromboxane receptor antagonist and synthase inhibitor DTTX-30 on intestinal O2-exchange and energy metabolism during hyperdynamic porcine endotoxemia. Matejovic, M., Radermacher, P., Zülke, C., Vlatten, A., Altherr, J., Brinkmann, A., Brückner, U.B., Jauch, K.W., Georgieff, M., Träger, K. Shock (2000) [Pubmed]
  12. Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation. Yokoyama, I., Kobayashi, T., Negita, M., Hayashi, S., Yasutomi, M., Katayama, A., Uchida, K., Takagi, H. Transpl. Int. (1996) [Pubmed]
  13. The porcine thromboxane synthase-encoding cDNA: sequence, mRNA expression and enzyme production in Sf9 insect cells. Shen, R.F., Zhang, L., Baek, S.J., Tai, H.H., Lee, K.D. Gene (1994) [Pubmed]
  14. Effect of thromboxane synthase inhibitor, CS-518, on propranolol-induced bronchoconstriction in guinea pigs. Ishiura, Y., Fujimura, M., Myou, S., Amemiya, T., Nobata, K., Liu, Q., Yamamori, C., Matsuda, T. Drugs under experimental and clinical research. (2000) [Pubmed]
  15. Products of cyclooxygenase mediate the responses of the guinea pig trachea to hydrogen peroxide. Gao, Y., Vanhoutte, P.M. J. Appl. Physiol. (1993) [Pubmed]
  16. Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function. Itoh, K., Mukaiyama, O., Satoh, Y., Yamaguchi, T., Iizuka, Y. Eur. J. Pharmacol. (1993) [Pubmed]
  17. Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics. Chemtob, S., Hardy, P., Abran, D., Li, D.Y., Peri, K., Cuzzani, O., Varma, D.R. J. Appl. Physiol. (1995) [Pubmed]
  18. Group B streptococcus promotes oxygen radical-dependent thromboxane accumulation in young piglets. Shook, L.A., Pauly, T.H., Marple, S.L., Horstman, S.J., Tai, H.H., Bowdy, B.D., Gillespie, M.N. Pediatr. Res. (1990) [Pubmed]
  19. eNOS and prostanoid enzymes in lungs of newborn piglets with chronic aortopulmonary shunts. Fike, C.D., Kaplowitz, M.R., Bousamra, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  20. Endogenous AA metabolites and their possible role in tracheal smooth muscle tone in guinea pigs. Yamane, K., Kobayashi, T. J. Appl. Physiol. (1990) [Pubmed]
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