Chemical Compound Review:
Ozagrelum (E)-3-[4-(imidazol-1- ylmethyl)phenyl]prop...
Synonyms:
ozagrel, Cataclot (TN), SureCN4210, CHEMBL11662, S2496_Selleck, ...
- ME3277, a GPIIb/IIIa antagonist reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery. Kawano, K.I., Fujishima, K., Ikeda, Y., Kondo, K., Umemura, K. J. Cereb. Blood Flow Metab. (2000)
- Antiplatelet and antithrombotic effects of YM337, the Fab fragment of a humanized anti-GPIIb/IIIa monoclonal antibody in monkeys. Kaku, S., Kawasaki, T., Hisamichi, N., Sakai, Y., Taniuchi, Y., Inagaki, O., Yano, S., Suzuki, K., Terazaki, C., Masuho, Y., Satoh, N., Takenaka, T., Yanagi, K., Ohshima, N. Thromb. Haemost. (1996)
- Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia. Ohyama, H., Hosomi, N., Takahashi, T., Mizushige, K., Kohno, M. Brain Res. (2001)
- Effects of sodium ozagrel on hemostatic markers and cerebral blood flow in lacunar infarction. Oishi, M., Mochizuki, Y., Hara, M., Yoshihashi, H., Takasu, T. Clinical neuropharmacology. (1996)
- Trial of prophylactic administration of TXA2 synthetase inhibitor, ozagrel hydrochloride, for preeclampsia. Seki, H., Kuromaki, K., Takeda, S., Kinoshita, K., Satoh, K. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy. (1999)
- Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models. Ichikawa, K., Tazawa, S., Hamano, S., Kojima, M., Hiraku, S. Pharmacology (1999)
- Involvement of thromboxane A2 and histamine in experimental allergic rhinitis of guinea pigs. Yamasaki, M., Matsumoto, T., Fukuda, S., Nakayama, T., Nagaya, H., Ashida, Y. J. Pharmacol. Exp. Ther. (1997)
- Restoration of middle cerebral artery thrombosis by novel glycoprotein IIb/IIIa antagonist FK419 in guinea pig. Moriguchi, A., Mihara, K., Aoki, T., Maeda, M., Tojo, N., Matsuoka, N., Mutoh, S. Eur. J. Pharmacol. (2004)
- Thromboxane A(2) synthase inhibitor enhanced antithrombotic efficacy of GPIIb-IIIa receptor antagonist without increasing bleeding. Kawano, K.I., Hokamura, K., Kondo, K., Ikeda, Y., Suzuki, Y., Umemura, K. Eur. J. Pharmacol. (2001)
- Pharmacokinetics of ozagrel and its metabolites after intravenous and oral administrations. Ogiso, T., Iwaki, M., Hara, Y., Tanino, T. Journal of pharmaceutical sciences. (1997)
- Effects of thromboxane A2 synthase inhibitors (CV-4151 and ozagrel), aspirin, and ticlopidine on the thrombosis caused by endothelial cell injury. Terashita, Z., Imura, Y., Kawamura, M., Kato, K., Nishikawa, K. Thromb. Res. (1995)
- Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger. Imamura, T., Kiguchi, S., Kobayashi, K., Ichikawa, K., Yamazaki, Y., Kojima, M. Arzneimittel-Forschung. (2003)
- Intracoronary administration of a thromboxane A2 synthase inhibitor relieves acetylcholine-induced coronary spasm. Sueda, S., Kohno, H., Inoue, K., Fukuda, H., Suzuki, J., Watanabe, K., Ochi, N., Kawada, H., Uraoka, T. Circ. J. (2002)
- Beneficial effect of combination therapy with ozagrel and pranlukast in exercise-induced asthma demonstrated by krypton-81 m ventilation scintigraphy--a case report. Takahashi, N., Ishibashi, Y., Murakami, Y., Shimizu, H., Ohta, Y., Asanuma, T., Katoh, H., Sano, K., Shimada, T. Ann. Acad. Med. Singap. (2000)
- Effect of a selective thromboxane A(2) synthetase inhibitor on the systemic changes induced by circulating pancreatic phospholipase A(2). Motoyoshi, M., Sugiyama, M., Atomi, Y., Kimura, W., Nagawa, H. J. Gastroenterol. (2006)
- Pharmacokinetic and pharmacodynamic studies of a thromboxane synthetase inhibitor, ozagrel, in rabbits. Zheng, N.X., Sato, H., Adachi, I., Kanamoto, I., Horikoshi, I. Biol. Pharm. Bull. (1995)
- Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells. Yamaguchi, T., Oishi, K., Uchida, M., Echizen, H. Biol. Pharm. Bull. (2003)
- Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack. Aizawa, H., Makita, Y., Sumitomo, K., Aburakawa, Y., Katayama, T., Nakatani-Enomoto, S., Suzuki, Y., Fujiwara, K., Enomoto, H., Kuroda, K., Kimura, T., Yahara, O., Koyama, S., Maruyama, J., Nakamura, M., Hasebe, N., Kikuchi, K. Intern. Med. (2006)
- Origin of thromboxane-mediated constriction due to neuropeptides in canine basilar artery. Tsuji, T., Cook, D.A. Eur. J. Pharmacol. (1994)
- Ibuprofen or ozagrel increases NO release and l-nitro arginine induces TXA(2) release from cultured porcine basilar arterial endothelial cells. Miyamoto, A., Hashiguchi, Y., Obi, T., Ishiguro, S., Nishio, A. Vascul. Pharmacol. (2007)
- Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation. Yokoyama, I., Kobayashi, T., Negita, M., Hayashi, S., Yasutomi, M., Katayama, A., Uchida, K., Takagi, H. Transpl. Int. (1996)
- Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patients. Myou, S., Fujimura, M., Nishi, K., Kita, T., Kurashima, K., Tachibana, H., Ishiura, Y., Nakao, S. Prostaglandins Leukot. Essent. Fatty Acids (2002)
- Rectal absorption of ozagrel from a suppository containing its commercial tablet in healthy human subjects. Zheng, N.X., Sato, H., Kobayashi, F., Masuko, Y., Adachi, I., Horikoshi, I. Biol. Pharm. Bull. (1997)