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Gene Review

ESR1  -  estrogen receptor 1

Bos taurus

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Disease relevance of LOC407238


High impact information on LOC407238

  • We found that suppression of GPR30 but not ER-alpha prevented E2-BSA- or E2-induced PKA activation and Bcl-2 expression [4].
  • At 2 hours after trauma-hemorrhage, administration of E2-conjugated to bovine serum albumin (E2-BSA, membrane impermeable) or E2 induced the up-regulation of ER-alpha and GPR30 and attenuated hepatic injury [4].
  • We propose a new model of ligand-independent activation of estrogen receptors in which the level of phosphorylation of ERalpha, and hence its transcriptional activation, is determined by the net effect of these counterregulatory pathways [5].
  • We now report that ERalpha-dependent gene expression also is regulated by protein phosphatase 2A (PP2A) [5].
  • It has recently been shown that kinase-mediated phosphorylation of ERalpha also transcriptionally activates the receptor in the absence of estrogen [5].

Chemical compound and disease context of LOC407238


Biological context of LOC407238


Anatomical context of LOC407238


Associations of LOC407238 with chemical compounds


Other interactions of LOC407238


Analytical, diagnostic and therapeutic context of LOC407238


  1. Estrogen receptor-alpha mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons. Chaban, V.V., Micevych, P.E. J. Neurosci. Res. (2005) [Pubmed]
  2. 17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease. Miyazaki-Akita, A., Hayashi, T., Ding, Q.F., Shiraishi, H., Nomura, T., Hattori, Y., Iguchi, A. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  3. Evaluation of potential implication of membrane estrogen binding sites on ERE-dependent transcriptional activity and intracellular estrogen receptor-alpha regulation in MCF-7 breast cancer cells. Seo, H.S., Leclercq, G. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  4. G protein-coupled receptor 30-dependent protein kinase a pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage. Hsieh, Y.C., Yu, H.P., Frink, M., Suzuki, T., Choudhry, M.A., Schwacha, M.G., Chaudry, I.H. Am. J. Pathol. (2007) [Pubmed]
  5. Regulation of estrogen receptor alpha-mediated transcription by a direct interaction with protein phosphatase 2A. Lu, Q., Surks, H.K., Ebling, H., Baur, W.E., Brown, D., Pallas, D.C., Karas, R.H. J. Biol. Chem. (2003) [Pubmed]
  6. Transient inhibition of synergistically insulin-like growth factor-1- and bisphenol A-induced poliferation of estrogen receptor alpha (ERalpha)-positive human breast cancer MCF-7 cells by melatonin. Ishido, M. Environmental sciences : an international journal of environmental physiology and toxicology. (2004) [Pubmed]
  7. Stimulation of the novel estrogen receptor-alpha intronic TERP-1 promoter by estrogens, androgen, pituitary adenylate cyclase-activating peptide, and forskolin, and autoregulation by TERP-1 protein. Bryant, W.M., Gibson, M.A., Shupnik, M.A. Endocrinology (2006) [Pubmed]
  8. Estrogen receptor-alpha gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration. Tan, E., Gurjar, M.V., Sharma, R.V., Bhalla, R.C. Cardiovasc. Res. (1999) [Pubmed]
  9. Occurrence of estrogen receptor alpha in bovine placentomes throughout mid and late gestation and at parturition. Schuler, G., Wirth, C., Teichmann, U., Failing, K., Leiser, R., Thole, H., Hoffmann, B. Biol. Reprod. (2002) [Pubmed]
  10. Estrogens inhibit l-glutamate uptake activity of astrocytes via membrane estrogen receptor alpha. Sato, K., Matsuki, N., Ohno, Y., Nakazawa, K. J. Neurochem. (2003) [Pubmed]
  11. Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Kim, H.P., Lee, J.Y., Jeong, J.K., Bae, S.W., Lee, H.K., Jo, I. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  12. Expression and localization of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in the bovine oviduct in vivo and in vitro. Ulbrich, S.E., Kettler, A., Einspanier, R. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  13. Pituitary estrogen receptor alpha and dopamine subtype 2 receptor gene expression in transgenic mice with overproduction of heterologous growth hormones. Vidal, S., Stefaneanu, L., Kovacs, K., Yamada, S., Bartke, A. Histochem. Cell Biol. (1999) [Pubmed]
  14. Expression of estrogen receptor alpha and 17beta-hydroxysteroid dehydrogenase 4 in the ciliary body. Kobayashi, K., Iwakiri, R., Kobayashi, H., Okinami, S. Graefes Arch. Clin. Exp. Ophthalmol. (2004) [Pubmed]
  15. Expression of the estrogen receptor in blood neutrophils of dairy cows during the periparturient period. Lamote, I., Meyer, E., De Ketelaere, A., Duchateau, L., Burvenich, C. Theriogenology (2006) [Pubmed]
  16. Estrogen receptor alpha and beta expression in the porcine ovary. Słomczyńska, M., Duda, M., Galas, J. Folia Histochem. Cytobiol. (2001) [Pubmed]
  17. Effects of bovine somatotropin on uterine genes related to the prostaglandin cascade in lactating dairy cows. Balaguer, S.A., Pershing, R.A., Rodriguez-Sallaberry, C., Thatcher, W.W., Badinga, L. J. Dairy Sci. (2005) [Pubmed]
  18. Distribution of estrogen receptor alpha in the dominant follicles and corpus luteum at the three stages of estrous cycle in Japanese black cows. Amrozi, n.u.l.l., Kamimura, S., Ando, T., Hamana, K. J. Vet. Med. Sci. (2004) [Pubmed]
  19. Mammary epithelial proliferation and estrogen receptor alpha expression in prepubertal heifers: effects of ovariectomy and growth hormone. Berry, S.D., Jobst, P.M., Ellis, S.E., Howard, R.D., Capuco, A.V., Akers, R.M. J. Dairy Sci. (2003) [Pubmed]
  20. Cell-specific distribution of oestrogen receptor-alpha in the bovine ovary. Van Den Broeck, W., Coryn, M., Simoens, P., Lauwers, H. Reprod. Domest. Anim. (2002) [Pubmed]
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