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ANXA5  -  annexin A5

Gallus gallus

 
 
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Disease relevance of ANXA5

  • These findings strongly indicate that human liver E-II is a very specific small HBsAg-binding protein and support the assumption that human liver E-II is the hepatitis B virus receptor protein [1].
  • In situ hybridization identified anchorin CII also in the otic vesicle adjacent to the site of contact with the statoacoustic ganglion and in the mandibular mesenchyme [2].
  • To determine if this rise in [Ca(2+)](i) functionally participates in the maturational process of growth plate chondrocytes (GPCs), we examined its effect on several markers of hypertrophy, including annexin V, bone morphogenetic protein-6, type X collagen, and indian hedgehog [3].
  • Spontaneous development of anti-hepatitis B virus envelope (anti-idiotypic) antibodies in animals immunized with human liver endonexin II or with the F(ab')2 fragment of anti-human liver endonexin II immunoglobulin G: evidence for a receptor-ligand-like relationship between small hepatitis B surface antigen and endonexin II [1].
  • Absence of cell-surface annexin V is accompanied by defective collagen matrix binding in the Swarm rat chondrosarcoma [4].
 

High impact information on ANXA5

 

Biological context of ANXA5

 

Anatomical context of ANXA5

 

Associations of ANXA5 with chemical compounds

  • Amino-terminal sequence analysis of the peptides generated by site-specific cleavage of the 33- and the 36-kDa MV annexins at tryptophan residues indicate that the 33 kDa is highly homologous to anchorin CII, a protein known to bind type II collagen, while the 36-kDa protein shares close homology with endonexin II, a tyrosine kinase substrate [13].
  • Chelating cytosolic Ca(2+) with BAPTA-AM, interfering with annexin Ca(2+) channel activities using K-201, a specific annexin Ca(2+) channel blocker, or suppression of annexin V expression using siRNA inhibited these events [11].
  • Overexpression of annexin V in embryonic chicken growth plate chondrocytes resulted in an increase of cytoplasmic Ca(2+) concentration, [Ca(2+)](i) similar to [Ca(2+)](i) increase in RA-treated cultures [11].
  • When MVs are fused with planar phospholipid bilayers, a multiconductance Ca2+ channel is formed, with activity essentially identical to that observed when annexin V is delivered to the bilayer with phosphatidylserine liposomes [14].
  • In addition, a significant fraction of annexin V associated with phosphatidylserine-rich liposomes was not extractable by EDTA treatment but required a detergent, indicating that annexin V inserts into bilayers of these liposomes [15].
 

Other interactions of ANXA5

 

Analytical, diagnostic and therapeutic context of ANXA5

References

  1. Spontaneous development of anti-hepatitis B virus envelope (anti-idiotypic) antibodies in animals immunized with human liver endonexin II or with the F(ab')2 fragment of anti-human liver endonexin II immunoglobulin G: evidence for a receptor-ligand-like relationship between small hepatitis B surface antigen and endonexin II. Hertogs, K., Depla, E., Crabbé, T., De Bruin, W., Leenders, W., Moshage, H., Yap, S.H. J. Virol. (1994) [Pubmed]
  2. Expression of anchorin CII, a collagen-binding protein of the annexin family, in the developing chick embryo. Hofmann, C., Gropp, R., von der Mark, K. Dev. Biol. (1992) [Pubmed]
  3. Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Zuscik, M.J., D'Souza, M., Ionescu, A.M., Gunter, K.K., Gunter, T.E., O'Keefe, R.J., Schwarz, E.M., Puzas, J.E., Rosier, R.N. Exp. Cell Res. (2002) [Pubmed]
  4. Absence of cell-surface annexin V is accompanied by defective collagen matrix binding in the Swarm rat chondrosarcoma. King, K.B., Chubinskaya, S., Reid, D.L., Madsen, L.H., Mollenhauer, J. J. Cell. Biochem. (1997) [Pubmed]
  5. Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes. Kirsch, T., Nah, H.D., Shapiro, I.M., Pacifici, M. J. Cell Biol. (1997) [Pubmed]
  6. Biosynthesis, secretion and extracellular localization of anchorin CII, a collagen-binding protein of the calpactin family. Pfäffle, M., Ruggiero, F., Hofmann, H., Fernández, M.P., Selmin, O., Yamada, Y., Garrone, R., von der Mark, K. EMBO J. (1988) [Pubmed]
  7. The structure of anchorin CII, a collagen binding protein isolated from chondrocyte membrane. Fernandez, M.P., Selmin, O., Martin, G.R., Yamada, Y., Pfäffle, M., Deutzmann, R., Mollenhauer, J., von der Mark, K. J. Biol. Chem. (1990) [Pubmed]
  8. The structure of anchorin CII, a collagen binding protein isolated from chondrocyte membrane. Pilar Fernandez, M., Selmin, O., Martin, G.R., Yamada, Y., Pfäffle, M., Deutzmann, R., Mollenhauer, J., von der Mark, K. J. Biol. Chem. (1988) [Pubmed]
  9. Isolation, characterization and localization of annexin V from chicken liver. Boustead, C.M., Brown, R., Walker, J.H. Biochem. J. (1993) [Pubmed]
  10. Structure of the gene encoding anchorin CII (chick annexin V). Fernández, M.P., Fernández, M.R., Morgan, R.O. Gene (1994) [Pubmed]
  11. Annexin V and terminal differentiation of growth plate chondrocytes. Wang, W., Xu, J., Kirsch, T. Exp. Cell Res. (2005) [Pubmed]
  12. DT40 cells lacking the Ca2+-binding protein annexin 5 are resistant to Ca2+-dependent apoptosis. Hawkins, T.E., Das, D., Young, B., Moss, S.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  13. Matrix vesicle annexins exhibit proteolipid-like properties. Selective partitioning into lipophilic solvents under acidic conditions. Genge, B.R., Wu, L.N., Adkisson, H.D., Wuthier, R.E. J. Biol. Chem. (1991) [Pubmed]
  14. Similarity in calcium channel activity of annexin V and matrix vesicles in planar lipid bilayers. Arispe, N., Rojas, E., Genge, B.R., Wu, L.N., Wuthier, R.E. Biophys. J. (1996) [Pubmed]
  15. Annexin V-mediated calcium flux across membranes is dependent on the lipid composition: implications for cartilage mineralization. Kirsch, T., Nah, H.D., Demuth, D.R., Harrison, G., Golub, E.E., Adams, S.L., Pacifici, M. Biochemistry (1997) [Pubmed]
  16. The roles of annexins and types II and X collagen in matrix vesicle-mediated mineralization of growth plate cartilage. Kirsch, T., Harrison, G., Golub, E.E., Nah, H.D. J. Biol. Chem. (2000) [Pubmed]
  17. Role of anchorin CII, a 31,000-mol-wt membrane protein, in the interaction of chondrocytes with type II collagen. Mollenhauer, J., Bee, J.A., Lizarbe, M.A., von der Mark, K. J. Cell Biol. (1984) [Pubmed]
  18. Calcium-dependent conformational rearrangements and protein stability in chicken annexin A5. Turnay, J., Olmo, N., Gasset, M., Iloro, I., Arrondo, J.L., Lizarbe, M.A. Biophys. J. (2002) [Pubmed]
 
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