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Gene Review

MCC  -  mutated in colorectal cancers

Homo sapiens

Synonyms: Colorectal mutant cancer protein, Protein MCC
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Disease relevance of MCC


Psychiatry related information on MCC


High impact information on MCC


Chemical compound and disease context of MCC


Biological context of MCC


Anatomical context of MCC


Associations of MCC with chemical compounds


Regulatory relationships of MCC

  • We evaluated 20 additional cases of MCC and found that 21 of 22 tumors (95%) expressed CD117 [23].
  • Overexpression of the MCC protein blocked the serum-induced cell cycle transition from the G1 to S phase, whereas a mutant MCC, initially identified in a colorectal tumor, did not exhibit this activity [24].
  • CONCLUSIONS: MCC possesses the ability to directly induce apoptosis of LNCaP cells and to trigger the synthesis of IL-12 and GM-CSF by these cells, suggesting a potential role of MCC for the treatment of prostate cancer [25].

Other interactions of MCC

  • Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis [16].
  • The morphological and molecular features of MCC1 and its corresponding primary tumor are consistent with a model for non-invasive MCC, where K-RAS, P16, P53 and MUC1 alterations are pre-invasive changes associated with progression of malignancy of MCT from adenoma to carcinoma [4].
  • Here we report the identification of five polymorphic systems in MCC gene (both cDNA and genomic), one of which is an insertion/deletion polymorphism that is detectable by a polymerase chain reaction method [26].
  • PBL, LPL and IEL demonstrated MICC for Chang cells but, contrasting with PBL and LPL, IEL showed no MCC for CRBC [27].
  • We investigated the frequency and clinical significance of loss of heterozygosity (LOH) at the APC, MCC, and DCC tumor suppressor gene loci in 108 cases of resected non-small cell lung cancer (NSCLC) [28].

Analytical, diagnostic and therapeutic context of MCC


  1. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., Hedge, P. Science (1991) [Pubmed]
  2. Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. Curtis, L.J., Bubb, V.J., Gledhill, S., Morris, R.G., Bird, C.C., Wyllie, A.H. Hum. Mol. Genet. (1994) [Pubmed]
  3. Three submicroscopic deletions at the APC locus and their rapid detection by quantitative-PCR analysis. De Rosa, M., Scarano, M.I., Panariello, L., Carlomagno, N., Rossi, G.B., Tempesta, A., Borgheresi, P., Renda, A., Izzo, P. Eur. J. Hum. Genet. (1999) [Pubmed]
  4. Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion. Sorio, C., Capelli, P., Lissandrini, D., Moore, P.S., Balzarini, P., Falconi, M., Zamboni, G., Scarpa, A. Virchows Arch. (2005) [Pubmed]
  5. Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region. Hampton, G.M., Ward, J.R., Cottrell, S., Howe, K., Thomas, H.J., Ballhausen, W.G., Jones, T., Sheer, D., Solomon, E., Frischauf, A.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. MCC expands its offerings in managed mental health. Brightbill, T. Contract healthcare. (1988) [Pubmed]
  7. Identification of deletion mutations and three new genes at the familial polyposis locus. Joslyn, G., Carlson, M., Thliveris, A., Albertsen, H., Gelbert, L., Samowitz, W., Groden, J., Stevens, J., Spirio, L., Robertson, M. Cell (1991) [Pubmed]
  8. Identification of FAP locus genes from chromosome 5q21. Kinzler, K.W., Nilbert, M.C., Su, L.K., Vogelstein, B., Bryan, T.M., Levy, D.B., Smith, K.J., Preisinger, A.C., Hedge, P., McKechnie, D. Science (1991) [Pubmed]
  9. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Kinzler, K.W., Nilbert, M.C., Vogelstein, B., Bryan, T.M., Levy, D.B., Smith, K.J., Preisinger, A.C., Hamilton, S.R., Hedge, P., Markham, A. Science (1991) [Pubmed]
  10. Association between genetic variants of mast-cell chymase and eczema. Mao, X.Q., Shirakawa, T., Yoshikawa, T., Yoshikawa, K., Kawai, M., Sasaki, S., Enomoto, T., Hashimoto, T., Furuyama, J., Hopkin, J.M., Morimoto, K. Lancet (1996) [Pubmed]
  11. Biochemical characterization of biotin-responsive multiple carboxylase deficiency: heterogeneity within the bio genetic complementation group. Feldman, G.L., Hsia, Y.E., Wolf, B. Am. J. Hum. Genet. (1981) [Pubmed]
  12. Triplet combination with irinotecan plus oxaliplatin plus continuous-infusion fluorouracil and leucovorin as first-line treatment in metastatic colorectal cancer: a multicenter phase II trial. Souglakos, J., Mavroudis, D., Kakolyris, S., Kourousis, C.h., Vardakis, N., Androulakis, N., Agelaki, S., Kalbakis, K., Tsetis, D., Athanasiadis, N., Samonis, G., Georgoulias, V. J. Clin. Oncol. (2002) [Pubmed]
  13. Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides. Martinez, A., Esteban, A.I., Castro, A., Gil, C., Conde, S., Andrei, G., Snoeck, R., Balzarini, J., De Clercq, E. J. Med. Chem. (1999) [Pubmed]
  14. FOLFOX-4 Stop and Go and Capecitabine Maintenance Chemotherapy in the Treatment of Metastatic Colorectal Cancer. Petrioli, R., Paolelli, L., Marsili, S., Civitelli, S., Francini, E., Cioppa, T., Roviello, F., Nettuno, R., Intrivici, C., Tanzini, G., Lorenzi, M., Francini, G. Oncology (2006) [Pubmed]
  15. Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: a phase II trial. Souglakos, J., Pallis, A., Kakolyris, S., Mavroudis, D., Androulakis, N., Kouroussis, C., Agelaki, S., Xenidis, N., Milaki, G., Georgoulias, V. Oncology (2005) [Pubmed]
  16. Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis. Rhyu, M.G., Park, W.S., Jung, Y.J., Choi, S.W., Meltzer, S.J. Gastroenterology (1994) [Pubmed]
  17. Exclusion of APC and MCC as the gene defect in one family with familial juvenile polyposis. Leggett, B.A., Thomas, L.R., Knight, N., Healey, S., Chenevix-Trench, G., Searle, J. Gastroenterology (1993) [Pubmed]
  18. Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion. Barber, J.C., Ellis, K.H., Bowles, L.V., Delhanty, J.D., Ede, R.F., Male, B.M., Eccles, D.M. J. Med. Genet. (1994) [Pubmed]
  19. Genetic aspects of colorectal cancer: the surgeon's view. Sjödahl, R., Nyström, P.O. Scand. J. Gastroenterol. Suppl. (1996) [Pubmed]
  20. Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Boynton, R.F., Blount, P.L., Yin, J., Brown, V.L., Huang, Y., Tong, Y., McDaniel, T., Newkirk, C., Resau, J.H., Raskind, W.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  21. Metaplastic breast carcinoma: pathology and clinical outcome. Bellino, R., Arisio, R., D'Addato, F., Attini, R., Durando, A., Danese, S., Bertone, E., Grio, R., Massobrio, M. Anticancer Res. (2003) [Pubmed]
  22. Cloning of the human MCCA and MCCB genes and mutations therein reveal the molecular cause of 3-methylcrotonyl-CoA: carboxylase deficiency. Holzinger, A., Röschinger, W., Lagler, F., Mayerhofer, P.U., Lichtner, P., Kattenfeld, T., Thuy, L.P., Nyhan, W.L., Koch, H.G., Muntau, A.C., Roscher, A.A. Hum. Mol. Genet. (2001) [Pubmed]
  23. CD117 (KIT receptor) expression in Merkel cell carcinoma. Su, L.D., Fullen, D.R., Lowe, L., Uherova, P., Schnitzer, B., Valdez, R. The American Journal of dermatopathology. (2002) [Pubmed]
  24. MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. Matsumine, A., Senda, T., Baeg, G.H., Roy, B.C., Nakamura, Y., Noda, M., Toyoshima, K., Akiyama, T. J. Biol. Chem. (1996) [Pubmed]
  25. Pro-apoptotic and immunomodulatory activity of a mycobacterial cell wall-DNA complex towards LNCaP prostate cancer cells. Reader, S., Ménard, S., Filion, B., Filion, M.C., Phillips, N.C. Prostate (2001) [Pubmed]
  26. Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene. Miyoshi, Y., Nishisho, I., Miki, Y., Mori, T., Kinzler, K.W., Vogelstein, B., Nakamura, Y. Jpn. J. Cancer Res. (1992) [Pubmed]
  27. Human colonic intraepithelial and lamina proprial lymphocytes: cytotoxicity in vitro and the potential effects of the isolation method on their functional properties. Chiba, M., Bartnik, W., ReMine, S.G., Thayer, W.R., Shorter, R.G. Gut (1981) [Pubmed]
  28. Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer. Fong, K.M., Zimmerman, P.V., Smith, P.J. Cancer Res. (1995) [Pubmed]
  29. Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization. Gayther, S., Wells, D., Gulati, K., Chapman, P., Burn, J., Delhanty, J.D. Ann. Hum. Genet. (1993) [Pubmed]
  30. Allelic loss involving the tumor suppressor genes APC and MCC and expression of the APC protein in the development of dysplasia and carcinoma in Barrett esophagus. Bektas, N., Donner, A., Wirtz, C., Heep, H., Gabbert, H.E., Sarbia, M. Am. J. Clin. Pathol. (2000) [Pubmed]
  31. Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin? Poulsen, M.G., Rischin, D., Porter, I., Walpole, E., Harvey, J., Hamilton, C., Keller, J., Tripcony, L. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  32. Prognostic significance of p27Kip1, p45Skp2 and Ki67 expression profiles in Merkel cell carcinoma, extracutaneous small cell carcinoma, and cutaneous squamous cell carcinoma. Fernández-Figueras, M.T., Puig, L., Musulen, E., Gilaberte, M., Ferrándiz, C., Lerma, E., Ariza, A. Histopathology (2005) [Pubmed]
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