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Gene Review

IL6  -  interleukin 6 (interferon, beta 2)

Ovis aries

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Disease relevance of IL6

  • CONCLUSIONS: In this clinically relevant septic shock model, alkaline phosphatase administration improved gas exchange, decreased interleukin-6 concentrations, and prolonged survival time [1].
  • Plasma tumour necrosis factor-alpha and interleukin-6 concentrations were increased after LPS treatment with and without hypoxia, but not by hypoxia alone [2].
  • This may involve upregulation of systemic IL-6 synthesis and transfer to gingiva in serum, resulting in enhanced IL-6 accumulation within the gingival tissues or reduced bone density allowing for a greater amount of alveolar bone loss [3].

High impact information on IL6


Biological context of IL6


Anatomical context of IL6

  • This protein is capable of causing increased immunoglobulin production in pokeweed mitogen stimulated ovine peripheral blood mononuclear cells at concentrations of 10-100 ng/ml, but it only causes very limited replication of B9 cells, a murine IL-6 dependent cell line [8].
  • Envenoming produced hepatocytes with Mallory body-like vacuoles which may be due to the increased plasmatic levels of TNF-alpha and IL6 [11].
  • At 5-15 h after endotoxin, amnion/chorion cytokine mRNAs increased [12- to 26-fold for interleukin (IL)-1beta, IL-6, and IL-8 mRNA and 3-fold for tumor necrosis factor-alpha mRNA] [12].
  • Plasma CM101 concentrations did not correlate with indexes of illness severity, leukocyte counts, or interleukin-6 or interleukin-8 plasma concentrations [13].
  • Coincident with the influx of granulocytes and other cells there was an increase in the level of mRNA for the cytokines IL-1 alpha, IL-1 beta, IL-6 and IL-8 [14].

Associations of IL6 with chemical compounds


Other interactions of IL6


Analytical, diagnostic and therapeutic context of IL6


  1. Beneficial effects of alkaline phosphatase in septic shock. Su, F., Brands, R., Wang, Z., Verdant, C., Bruhn, A., Cai, Y., Raaben, W., Wulferink, M., Vincent, J.L. Crit. Care Med. (2006) [Pubmed]
  2. Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain. Billiards, S.S., Nguyen, P.N., Scheerlinck, J.P., Phillips, D.J., Canny, B.J., Walker, D.W., Hirst, J.J. Biol. Neonate (2006) [Pubmed]
  3. Alveolar bone loss one year following ovariectomy in sheep. Johnson, R.B., Gilbert, J.A., Cooper, R.C., Dai, X., Newton, B.I., Tracy, R.R., West, W.F., DeMoss, T.L., Myers, P.J., Streckfus, C.F. J. Periodontol. (1997) [Pubmed]
  4. Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep. Kramer, B.W., Ikegami, M., Moss, T.J., Nitsos, I., Newnham, J.P., Jobe, A.H. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  5. Dose and time response after intraamniotic endotoxin in preterm lambs. Kramer, B.W., Moss, T.J., Willet, K.E., Newnham, J.P., Sly, P.D., Kallapur, S.G., Ikegami, M., Jobe, A.H. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  6. Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin. Jones, K.L., Brauman, J.N., Groome, N.P., de Kretser, D.M., Phillips, D.J. Endocrinology (2000) [Pubmed]
  7. Synergism of interleukin 6 and 1 alpha,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines. Duits, A.J., Dimjati, W., van de Winkel, J.G., Capel, P.J. J. Leukoc. Biol. (1992) [Pubmed]
  8. Cloning, sequencing and expression of the ovine interleukin 6 gene. Ebrahimi, B., Roy, D.J., Bird, P., Sargan, D.R. Cytokine (1995) [Pubmed]
  9. Optimization of an ovine antibody-secreting cell assay for detection of antigen-specific immunoglobulin production in peripheral blood leukocytes. Sedgmen, B.J., Lofthouse, S.A., Meeusen, E.N. Immunol. Cell Biol. (2003) [Pubmed]
  10. Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe. Jones, K.L., de Kretser, D.M., Clarke, I.J., Scheerlinck, J.P., Phillips, D.J. J. Endocrinol. (2004) [Pubmed]
  11. Histopathological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams. D'Suze, G., Salazar, V., Díaz, P., Sevcik, C., Azpurua, H., Bracho, N. Toxicon (2004) [Pubmed]
  12. Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs. Kallapur, S.G., Willet, K.E., Jobe, A.H., Ikegami, M., Bachurski, C.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  13. Isolation and identification of the group B streptococcal toxin CM101 from infants with sepsis. Sundell, H.W., Yan, H., Carter, C.E., Wamil, B.D., Wu, K., Gaddipati, R., Li, D., Hellerqvist, C.G. J. Pediatr. (2000) [Pubmed]
  14. Cytokine mRNA expression in skin in response to ectoparasite infection. Elhay, M.J., Hanrahan, C.F., Bowles, V.M., Seow, H.F., Andrews, A.E., Nash, A.D. Parasite Immunol. (1994) [Pubmed]
  15. Fetal responses to maternal and intra-amniotic lipopolysaccharide administration in sheep. Grigsby, P.L., Hirst, J.J., Scheerlinck, J.P., Phillips, D.J., Jenkin, G. Biol. Reprod. (2003) [Pubmed]
  16. Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep. Newnham, J.P., Kallapur, S.G., Kramer, B.W., Moss, T.J., Nitsos, I., Ikegami, M., Jobe, A.H. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  17. Single strand conformational polymorphisms (SSCPs) in the ovine IL1A and IL6 genes. Maddox, J.F., Hawken, R.J., Matthew, P., Davies, K.P. Anim. Genet. (1999) [Pubmed]
  18. Measurement of cytokine production by the monocytic cell line Mono Mac 6 using novel immunoradiometric assays for interleukin-1 beta and interleukin-6. Rafferty, B., Mower, J.A., Taktak, Y.S., Poole, S. J. Immunol. Methods (1991) [Pubmed]
  19. Granulocyte macrophage colony stimulating factor is elevated in alveolar macrophages from sheep naturally infected with maedi-visna virus and stimulates maedi-visna virus replication in macrophages in vitro. Zhang, Z., Harkiss, G.D., Hopkins, J., Woodall, C.J. Clin. Exp. Immunol. (2002) [Pubmed]
  20. Interleukin-6 expression in gut of parasite challenged sheep. Shen, J., Bao, S., McClure, S.J., Emery, D.L., Husband, A.J. Vet. Immunol. Immunopathol. (2000) [Pubmed]
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