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Gene Review

HMOX1  -  heme oxygenase (decycling) 1

Sus scrofa

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Disease relevance of HMOX1

  • Nucleotide sequence of cDNA for porcine heme oxygenase and its expression in Escherichia coli [1].
  • Heme oxygenase (HO), the heme-degrading enzyme, has shown anti-inflammatory effects in several models of pulmonary diseases [2].
  • In newborn pigs, the mechanism of seizure-induced cerebral hyperemia involves carbon monoxide (CO), the vasodilator product of heme catabolism by heme oxygenase (HO) [3].
  • Our results suggest a protective role of HO activation during hyperdynamic porcine endotoxemia possibly as a result of an interaction with the LPS-induced increase in NO formation [4].
  • The effects of the HO inhibitor, tin protoporphyrin (SnPP), on brain electrical activity and pial arteriolar diameter were examined using quantitative electroencephalography (EEG) and cranial window techniques in the bicuculline model of sustained generalized seizures in newborn pigs [5].

High impact information on HMOX1


Chemical compound and disease context of HMOX1


Biological context of HMOX1

  • The nucleotide sequence of a cDNA for porcine heme oxygenase was determined [1].
  • A prokaryotic expression plasmid carrying porcine heme oxygenase cDNA was constructed and transfected into Escherichia coli cells [1].
  • Tin protoporphyrin-IX (SnPP; 19 microM), an inhibitor of HO activity, completely abolished ANP-induced cytoprotection [8].
  • HO upregulation by repeated administrations of hemin (50 mg/kg i.p.) significantly decreased airway responsiveness in control animals and airway inflammation, mucus secretion, oxidative stress, and responsiveness in OVA animals [2].
  • Systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of the HO-inhibitor tin-mesoporphyrin (SnMP) were assessed in anesthetized and mechanically ventilated animals [4].

Anatomical context of HMOX1


Associations of HMOX1 with chemical compounds


Other interactions of HMOX1


Analytical, diagnostic and therapeutic context of HMOX1


  1. Nucleotide sequence of cDNA for porcine heme oxygenase and its expression in Escherichia coli. Suzuki, T., Sato, M., Ishikawa, K., Yoshida, T. Biochem. Int. (1992) [Pubmed]
  2. Heme oxygenase attenuates allergen-induced airway inflammation and hyperreactivity in guinea pigs. Almolki, A., Taillé, C., Martin, G.F., Jose, P.J., Zedda, C., Conti, M., Megret, J., Henin, D., Aubier, M., Boczkowski, J. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  3. Endogenous heme oxygenase prevents impairment of cerebral vascular functions caused by seizures. Carratu, P., Pourcyrous, M., Fedinec, A., Leffler, C.W., Parfenova, H. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  4. Tin-mesoporphyrin for inhibition of heme oxygenase during long-term hyperdynamic porcine endotoxemia. Nalos, M., Vassilev, D., Pittner, A., Asfar, P., Brückner, U.B., Schneider, E.M., Georgieff, M., Radermacher, P., Froeba, G. Shock (2003) [Pubmed]
  5. Heme oxygenase inhibition reduces neuronal activation evoked by bicuculline in newborn pigs. Parfenova, H., Daley, M.L., Carratu, P., Leffler, C.W. Brain Res. (2004) [Pubmed]
  6. Purification and properties of heme oxygenase from pig spleen microsomes. Yoshida, T., Kikuchi, G. J. Biol. Chem. (1978) [Pubmed]
  7. Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase. Parfenova, H., Fedinec, A., Leffler, C.W. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  8. Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1. Polte, T., Hemmerle, A., Berndt, G., Grosser, N., Abate, A., Schröder, H. Free Radic. Biol. Med. (2002) [Pubmed]
  9. Heme oxygenase activity and acute and chronic ethanol exposure in the hippocampus, frontal cerebral cortex, and cerebellum of the near-term fetal guinea pig. Cook, M.N., Marks, G.S., Vreman, H.J., Nakatsu, K., Stevenson, D.K., Brien, J.F. Alcohol (1997) [Pubmed]
  10. Inhibitory effect of an intracellular glutathione on delta 12-prostaglandin J2-induced protein syntheses in porcine aortic endothelial cells. Koizumi, T., Negishi, M., Ichikawa, A. Biochem. Pharmacol. (1992) [Pubmed]
  11. Inhibition by zinc protoporphyrin-IX of vasoactive intestinal peptide-induced relaxations of guinea pig isolated trachea. Undem, B.J., Ellis, J.L., Meeker, S., Fischer, A., Canning, B.J. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  12. Inability of the NADH-cytochrome b5 reductase system to initiate heme degradation yielding biliverdin IX alpha from the oxygenated form of heme . heme oxygenase complex. Yoshida, T., Noguchi, M., Kikuchi, G. FEBS Lett. (1980) [Pubmed]
  13. Heme oxygenase activity, drug metabolism, amd ascorbic acid distribution in the livers of ascorbic acid-deficient guinea pigs. Omaye, S.T., Turnbull, J.D. Biochem. Pharmacol. (1979) [Pubmed]
  14. Effects of hypoxia on stress proteins in the piglet heart at birth. Louapre, P., Grongnet, J.F., Tanguay, R.M., David, J.C. Cell Stress Chaperones (2005) [Pubmed]
  15. Stereologic description of the changing expression of constitutive nitric oxide synthase and heme oxygenase in the enteric plexuses of the pig small intestine during development. van Ginneken, C., van Meir, F., Sys, S., Weyns, A. J. Comp. Neurol. (2001) [Pubmed]
  16. NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium. Motterlini, R., Foresti, R., Intaglietta, M., Winslow, R.M. Am. J. Physiol. (1996) [Pubmed]
  17. Heme oxygenase purified to apparent homogeneity from pig spleen microsomes. Yoshida, T., Kikuchi, G. J. Biochem. (1977) [Pubmed]
  18. The induction of carbon monoxide-mediated airway relaxation by PACAP 38 in isolated guinea pig airways. Kinhult, J., Uddman, R., Cardell, L.O. Lung (2001) [Pubmed]
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