Gene Review:
MYLK - myosin light chain kinase
Homo sapiens
Synonyms:
AAT7, KRP, Kinase-related protein, MLCK, MLCK1, ...
- Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Gao, L., Grant, A., Halder, I., Brower, R., Sevransky, J., Maloney, J.P., Moss, M., Shanholtz, C., Yates, C.R., Meduri, G.U., Shriver, M.D., Ingersoll, R., Scott, A.F., Beaty, T.H., Moitra, J., Ma, S.F., Ye, S.Q., Barnes, K.C., Garcia, J.G. Am. J. Respir. Cell Mol. Biol. (2006)
- Effects of antibodies to myosin light chain kinase on contractility and myosin phosphorylation in chemically permeabilized smooth muscle. De Lanerolle, P., Strauss, J.D., Felsen, R., Doerman, G.E., Paul, R.J. Circ. Res. (1991)
- Structure and function of smooth muscle myosin light chain kinase. Kishi, H., Ye, L.H., Nakamura, A., Okagaki, T., Iwata, A., Tanaka, T., Kohama, K. Adv. Exp. Med. Biol. (1998)
- Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. Gao, L., Grant, A.V., Rafaels, N., Stockton-Porter, M., Watkins, T., Gao, P., Chi, P., Muñoz, M., Watson, H., Dunston, G., Togias, A., Hansel, N., Sevransky, J., Maloney, J.P., Moss, M., Shanholtz, C., Brower, R., Garcia, J.G., Grigoryev, D.N., Cheadle, C., Beaty, T.H., Mathias, R.A., Barnes, K.C. J. Allergy Clin. Immunol. (2007)
- Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Somlyo, A.P., Somlyo, A.V. Physiol. Rev. (2003)
- Inhibition of myosin light chain kinase by p21-activated kinase. Sanders, L.C., Matsumura, F., Bokoch, G.M., de Lanerolle, P. Science (1999)
- Myosin light chain kinase binding to a unique site on F-actin revealed by three-dimensional image reconstruction. Hatch, V., Zhi, G., Smith, L., Stull, J.T., Craig, R., Lehman, W. J. Cell Biol. (2001)
- Rho-kinase--mediated contraction of isolated stress fibers. Katoh, K., Kano, Y., Amano, M., Onishi, H., Kaibuchi, K., Fujiwara, K. J. Cell Biol. (2001)
- A genomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase (MYLK) gene is duplicated on human chromosome regions 3q13-q21 and 3p13. Brand-Arpon, V., Rouquier, S., Massa, H., de Jong, P.J., Ferraz, C., Ioannou, P.A., Demaille, J.G., Trask, B.J., Giorgi, D. Genomics (1999)
- The functional myosin light chain kinase (MYLK) gene localizes with marker D3S3552 on human chromosome 3q21 in a >5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes. Giorgi, D., Brand-Arpon, V., Rouquier, S. Cytogenet. Cell Genet. (2001)
- Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. Goeckeler, Z.M., Masaracchia, R.A., Zeng, Q., Chew, T.L., Gallagher, P., Wysolmerski, R.B. J. Biol. Chem. (2000)
- Localization and activity of myosin light chain kinase isoforms during the cell cycle. Poperechnaya, A., Varlamova, O., Lin, P.J., Stull, J.T., Bresnick, A.R. J. Cell Biol. (2000)
- Expression of a novel high molecular-weight myosin light chain kinase in endothelium. Verin, A.D., Lazar, V., Torry, R.J., Labarrere, C.A., Patterson, C.E., Garcia, J.G. Am. J. Respir. Cell Mol. Biol. (1998)
- Myosin light chain kinase in endothelium: molecular cloning and regulation. Garcia, J.G., Lazar, V., Gilbert-McClain, L.I., Gallagher, P.J., Verin, A.D. Am. J. Respir. Cell Mol. Biol. (1997)
- Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. Vijayan, K.V., Liu, Y., Dong, J.F., Bray, P.F. J. Biol. Chem. (2003)
- Contractility as a Prerequisite for TGF-{beta}-Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts. Meyer-Ter-Vehn, T., Sieprath, S., Katzenberger, B., Gebhardt, S., Grehn, F., Schlunck, G. Invest. Ophthalmol. Vis. Sci. (2006)
- Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker. Watterson, D.M., Schavocky, J.P., Guo, L., Weiss, C., Chlenski, A., Shirinsky, V.P., Van Eldik, L.J., Haiech, J. J. Cell. Biochem. (1999)
- EPEC-activated ERK1/2 participate in inflammatory response but not tight junction barrier disruption. Savkovic, S.D., Ramaswamy, A., Koutsouris, A., Hecht, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2001)
- Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity. Ye, D., Ma, T.Y. J. Cell. Mol. Med. (2008)
- Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Ye, D., Ma, I., Ma, T.Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery. Szczepanowska, J., Korn, E.D., Brzeska, H. Cell Motil. Cytoskeleton (2006)
- Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. Dudek, S.M., Jacobson, J.R., Chiang, E.T., Birukov, K.G., Wang, P., Zhan, X., Garcia, J.G. J. Biol. Chem. (2004)
- The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. Potier, M.C., Chelot, E., Pekarsky, Y., Gardiner, K., Rossier, J., Turnell, W.G. Genomics (1995)
- Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells. Geguchadze, R., Zhi, G., Lau, K.S., Isotani, E., Persechini, A., Kamm, K.E., Stull, J.T. FEBS Lett. (2004)