Gene Review:
PLAGL1 - pleiomorphic adenoma gene-like 1
Homo sapiens
Synonyms:
LOT-1, LOT1, Lost on transformation 1, Pleiomorphic adenoma-like protein 1, Tumor suppressor ZAC, ...
Cairns,
Apiou,
Van Valckenborgh,
Hoffmann,
Wake,
Kas,
Sasaki,
Nakabeppu,
Journot,
Van de Ven,
Voz,
Yamaguchi-Iwai,
Bilanges,
Yamasaki,
Roberts,
Sakumi,
Kambe,
Abdollahi,
Arima,
Hamilton,
Wake,
Bockaert,
Furukawa,
Tokunaga,
Hensen,
Kuwahara,
Spengler,
Pisarcik,
Taketani,
Pantaloni,
Arima,
Ikehara,
John,
Weinstein,
Fujisawa ,
Varrault,
Adachi,
Kato,
Ciani,
Kono,
- The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors. Poulin, H., Labelle, Y. Cancer Lett. (2005)
- ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome. Arima, T., Kamikihara, T., Hayashida, T., Kato, K., Inoue, T., Shirayoshi, Y., Oshimura, M., Soejima, H., Mukai, T., Wake, N. Nucleic Acids Res. (2005)
- Molecular analyses of the candidate tumor suppressor gene, PLAGL1, in benign and malignant salivary gland tumors. Enlund, F., Persson, F., Stenman, G. Eur. J. Oral Sci. (2004)
- Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis. Arima, T., Wake, N. Cytogenet. Genome Res. (2006)
- Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. Spengler, D., Villalba, M., Hoffmann, A., Pantaloni, C., Houssami, S., Bockaert, J., Journot, L. EMBO J. (1997)
- hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Varrault, A., Ciani, E., Apiou, F., Bilanges, B., Hoffmann, A., Pantaloni, C., Bockaert, J., Spengler, D., Journot, L. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Genome-wide allelotyping of a new in vitro model system reveals early events in breast cancer progression. Li, Z., Meng, Z.H., Sayeed, A., Shalaby, R., Ljung, B.M., Dairkee, S.H. Cancer Res. (2002)
- The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Hensen, K., Van Valckenborgh, I.C., Kas, K., Van de Ven, W.J., Voz, M.L. Cancer Res. (2002)
- Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. Van Dyck, F., Delvaux, E.L., Van de Ven, W.J., Chavez, M.V. J. Biol. Chem. (2004)
- LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. Abdollahi, A., Pisarcik, D., Roberts, D., Weinstein, J., Cairns, P., Hamilton, T.C. J. Biol. Chem. (2003)
- The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Arima, T., Yamasaki, K., John, R.M., Kato, K., Sakumi, K., Nakabeppu, Y., Wake, N., Kono, T. Genomics (2006)
- LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein. Abdollahi, A., Bao, R., Hamilton, T.C. Oncogene (1999)
- Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. Huang, S.M., Schönthal, A.H., Stallcup, M.R. Oncogene (2001)
- Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors. Abdollahi, A., Roberts, D., Godwin, A.K., Schultz, D.C., Sonoda, G., Testa, J.R., Hamilton, T.C. Oncogene (1997)
- The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas. Basyuk, E., Coulon, V., Le Digarcher, A., Coisy-Quivy, M., Moles, J.P., Gandarillas, A., Journot, L. Mol. Cancer Res. (2005)
- Multicenter clinical trial of zinc acexamate in the prevention of nonsteroidal antiinflammatory drug induced gastroenteropathy. Spanish Study Group on NSAID Induced Gastroenteropathy Prevention. Rodríguez de la Serna, A., Díaz-Rubio, M. J. Rheumatol. (1994)
- ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells. Lanaspa, M.A., Andres-Hernando, A., Rivard, C.J., Dai, Y., Li, N., Berl, T. J. Biol. Chem. (2009)
- Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines. Furukawa, T., Adachi, Y., Fujisawa , J., Kambe, T., Yamaguchi-Iwai, Y., Sasaki, R., Kuwahara, J., Ikehara, S., Tokunaga, R., Taketani, S. Oncogene (2001)
- Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma. Rutherford, S., Yu, Y., Rumpel, C.A., Frierson, H.F., Moskaluk, C.A. Cancer Lett. (2006)
- Induction of type I PACAP receptor expression by the new zinc finger protein Zac1 and p53. Hoffmann, A., Ciani, E., Houssami, S., Brabet, P., Journot, L., Spengler, D. Ann. N. Y. Acad. Sci. (1998)
- Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome. Mitchell, J., Punthakee, Z., Lo, B., Bernard, C., Chong, K., Newman, C., Cartier, L., Desilets, V., Cutz, E., Hansen, I.L., Riley, P., Polychronakos, C. Diabetologia (2004)
- Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer. Kamikihara, T., Arima, T., Kato, K., Matsuda, T., Kato, H., Douchi, T., Nagata, Y., Nakao, M., Wake, N. Int. J. Cancer (2005)
- Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. Cvetkovic, D., Pisarcik, D., Lee, C., Hamilton, T.C., Abdollahi, A. Gynecol. Oncol. (2004)
- Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors. Bilanges, B., Varrault, A., Basyuk, E., Rodriguez, C., Mazumdar, A., Pantaloni, C., Bockaert, J., Theillet, C., Spengler, D., Journot, L. Oncogene (1999)