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Gene Review

UGT2B15  -  UDP glucuronosyltransferase 2 family,...

Homo sapiens

Synonyms: HLUG4, UDP-glucuronosyltransferase 2B15, UDP-glucuronosyltransferase 2B8, UDPGT 2B15, UDPGT 2B8, ...
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Disease relevance of UGT2B15


High impact information on UGT2B15


Chemical compound and disease context of UGT2B15


Biological context of UGT2B15


Anatomical context of UGT2B15


Associations of UGT2B15 with chemical compounds


Enzymatic interactions of UGT2B15


Regulatory relationships of UGT2B15

  • In addition, LNCaP cells treated with dihydrotestosterone (DHT) and epidermal growth factor (EGF) express differential levels of the human UGT2B15 and UGT2B17 transcripts [22].
  • Prevalence of the UGT2B15 Asp85Tyr polymorphism was compared between cases and controls by allele specific polymerase chain reaction analysis using genomic DNA isolated from 155 incident white patients with primary prostate cancer and 155 individually age matched (+/-5 years) white controls [9].

Other interactions of UGT2B15


Analytical, diagnostic and therapeutic context of UGT2B15


  1. Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. Harrington, W.R., Sengupta, S., Katzenellenbogen, B.S. Endocrinology (2006) [Pubmed]
  2. Prostate cancer and polymorphism D85Y in gene for dihydrotestosterone degrading enzyme UGT2B15: Frequency of DD homozygotes increases with Gleason Score. Hajdinjak, T., Zagradisnik, B. Prostate (2004) [Pubmed]
  3. Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism. Tomboc, M., Witchel, S.F. Journal of pediatric endocrinology & metabolism : JPEM. (2003) [Pubmed]
  4. Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome type I. van Es, H.H., Goldhoorn, B.G., Paul-Abrahamse, M., Elferink, R.P., Jansen, P.L. J. Clin. Invest. (1990) [Pubmed]
  5. Mechanism of thiazopyr-induced effects on thyroid hormone homeostasis in male Sprague-Dawley rats. Hotz, K.J., Wilson, A.G., Thake, D.C., Roloff, M.V., Capen, C.C., Kronenberg, J.M., Brewster, D.W. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  6. Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. Sun, X.Y., Plouzek, C.A., Henry, J.P., Wang, T.T., Phang, J.M. Cancer Res. (1998) [Pubmed]
  7. Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. Beaulieu, M., Lévesque, E., Hum, D.W., Bélanger, A. J. Biol. Chem. (1996) [Pubmed]
  8. Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Chung, J.Y., Cho, J.Y., Yu, K.S., Kim, J.R., Jung, H.R., Lim, K.S., Jang, I.J., Shin, S.G. Clin. Pharmacol. Ther. (2005) [Pubmed]
  9. Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer. Park, J., Chen, L., Shade, K., Lazarus, P., Seigne, J., Patterson, S., Helal, M., Pow-Sang, J. J. Urol. (2004) [Pubmed]
  10. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Nowell, S.A., Ahn, J., Rae, J.M., Scheys, J.O., Trovato, A., Sweeney, C., MacLeod, S.L., Kadlubar, F.F., Ambrosone, C.B. Breast Cancer Res. Treat. (2005) [Pubmed]
  11. Gene therapy with bilirubin-UDP-glucuronosyltransferase in the Gunn rat model of Crigler-Najjar syndrome type 1. Li, Q., Murphree, S.S., Willer, S.S., Bolli, R., French, B.A. Hum. Gene Ther. (1998) [Pubmed]
  12. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. Turgeon, D., Carrier, J.S., Lévesque, E., Beatty, B.G., Bélanger, A., Hum, D.W. J. Mol. Biol. (2000) [Pubmed]
  13. Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes. Yamanaka, H., Nakajima, M., Katoh, M., Kanoh, A., Tamura, O., Ishibashi, H., Yokoi, T. Drug Metab. Dispos. (2005) [Pubmed]
  14. Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method. Tchernof, A., Lévesque, E., Beaulieu, M., Couture, P., Després, J.P., Hum, D.W., Bélanger, A. Clin. Endocrinol. (Oxf) (1999) [Pubmed]
  15. Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. Chouinard, S., Pelletier, G., Bélanger, A., Barbier, O. Endocr. Res. (2004) [Pubmed]
  16. Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Lévesque, E., Beaulieu, M., Green, M.D., Tephly, T.R., Bélanger, A., Hum, D.W. Pharmacogenetics (1997) [Pubmed]
  17. Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells. Guillemette, C., Lévesque, E., Beaulieu, M., Turgeon, D., Hum, D.W., Bélanger, A. Endocrinology (1997) [Pubmed]
  18. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. Sparks, R., Ulrich, C.M., Bigler, J., Tworoger, S.S., Yasui, Y., Rajan, K.B., Porter, P., Stanczyk, F.Z., Ballard-Barbash, R., Yuan, X., Lin, M.G., McVarish, L., Aiello, E.J., McTiernan, A. Breast Cancer Res. (2004) [Pubmed]
  19. N-glycosylation and residue 96 are involved in the functional properties of UDP-glucuronosyltransferase enzymes. Barbier, O., Girard, C., Breton, R., Bélanger, A., Hum, D.W. Biochemistry (2000) [Pubmed]
  20. UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells. Chouinard, S., Barbier, O., Bélanger, A. J. Biol. Chem. (2007) [Pubmed]
  21. The effect of valproic acid on drug and steroid glucuronidation by expressed human UDP-glucuronosyltransferases. Ethell, B.T., Anderson, G.D., Burchell, B. Biochem. Pharmacol. (2003) [Pubmed]
  22. Effect of fibroblastic growth factors (FGF) on steroid UDP-glucuronosyltransferase expression and activity in the LNCaP cell line. Lévesque, E., Beaulieu, M., Guillemette, C., Hum, D.W., Bélanger, A. J. Steroid Biochem. Mol. Biol. (1998) [Pubmed]
  23. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13. Monaghan, G., Clarke, D.J., Povey, S., See, C.G., Boxer, M., Burchell, B. Genomics (1994) [Pubmed]
  24. Regioselective and stereospecific glucuronidation of trans- and cis-resveratrol in human. Aumont, V., Krisa, S., Battaglia, E., Netter, P., Richard, T., Mérillon, J.M., Magdalou, J., Sabolovic, N. Arch. Biochem. Biophys. (2001) [Pubmed]
  25. The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases. Lautala, P., Ethell, B.T., Taskinen, J., Burchell, B. Drug Metab. Dispos. (2000) [Pubmed]
  26. Expression of transcripts encoding steroid UDP-glucuronosyltransferases in human prostate hyperplastic tissue and the LNCaP cell line. Bélanger, G., Beaulieu, M., Marcotte, B., Lévesque, E., Guillemette, C., Hum, D.W., Bélanger, A. Mol. Cell. Endocrinol. (1995) [Pubmed]
  27. Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase. Coffman, B.L., Tephly, T.R., Irshaid, Y.M., Green, M.D., Smith, C., Jackson, M.R., Wooster, R., Burchell, B. Arch. Biochem. Biophys. (1990) [Pubmed]
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