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Gene Review

TXNL4B  -  thioredoxin-like 4B

Homo sapiens

Synonyms: DIM2, DLP, Dim1-like protein, Dim2, FLJ20511, ...
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Disease relevance of TXNL4B

  • There is a strong rationale for the initiation of DLP treatment in childhood to limit the earliest stages of atherosclerosis, to establish lifelong lifestyle changes in diet and activity, and to limit the acquisition of additional CVD risk factors such as smoking and obesity [1].
  • It was reported previously that the MCI in IPSID is characteristically diffuse plasmacytic or lymphoplasmacytic (DLP) [2].
  • CONCLUSIONS: The results of our study have shown that moderate to severe fibrosis in the detrusor and a DLPP of more than 75 cm H2O are the risk factors for UUT deterioration in patients with ONBD [3].
  • The human gene coding for the spliceosomal protein thioredoxin-like 4B (TXNL4B) was overexpressed in Escherichia coli and the encoded protein was purified and crystallized [4].
  • In 203 HIV infected patients in various clinical stages neurological examination, paired stimulation (LPSS), nerve conduction velocity (NCVS) and amplitude (AMPS) of the sural nerve, distal latency (DLP), nerve conduction velocity (NCVP), amplitude (AMPP) and F waves of the peroneal nerve were recorded [5].

Psychiatry related information on TXNL4B

  • Until month 20, DLP care improved symptoms and social adjustment slightly more, and enhanced patients' and relatives' satisfaction [6].

High impact information on TXNL4B

  • Collectively, our experiments indicated that DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing [7].
  • Thus, besides its expected role in mitochondrial fission the trypanosomal DLP is required for endocytosis, a function thought to be restricted to classical dynamins [8].
  • In agreement with its dual function, the DLP localizes to both the mitochondrion and the flagellar pocket, the site where endocytosis occurs [8].
  • Unexpectedly, ablation of DLP also causes an arrest of cytokinesis [8].
  • Fecal monitoring was used as the standard against which the DL methods based on urine data (DLU), plasma data (DLP), and plasma kinetics with the use of a deconvolution analysis (DP) were compared [9].

Biological context of TXNL4B

  • A urodynamic risk score (URS) was calculated, including a detrusor leak-point pressure (DLPP) of >40 cmH(2)O, a bladder compliance (BC) of <9 mL/cmH(2)O and evidence of acontractile detrusor (ACD) [10].
  • DISCUSSION: Whereas expansion of cell numbers, CFU-GM and granulocytic post-progenitors in Cell Factories mirrored that achieved in T25-flasks, future preclinical studies with the DLPP cytokine combination may be performed in small volumes, with subsequent translation to the larger volume Cell Factories [11].

Anatomical context of TXNL4B

  • Here we report that Baxinduced mitochondrial fission is abolished in cell lines lacking functional DLP suggesting that the protein is also required for mitochondrial division during the cell cycle [8].
  • Injections of 3H-proline/leucine confirmed a previous report that the optic tectum projects to the nucleus dorsolateralis posterior of the thalamus (DLP) [12].
  • Injections of horseradish peroxidase at various locations in the neostriatal DLP terminal field demonstrated a rostrocaudal ordering of the DLP projection upon the neostriatum intermedium [12].
  • The distal pressure line of the Gundry DLP RCSP retrograde cardioplegia cannula (DPL, Inc., Grand Rapids, Mich.) was connected to a transducer, flushed, and then introduced into the right atrium [13].
  • OBJECTIVES: To determine whether bladder histopathologic changes, detrusor leak point pressure (DLPP), disease duration, and preoperative catheterization time can predict for upper urinary tract (UUT) deterioration in patients with overactive neurogenic bladder dysfunction (ONBD) [3].

Associations of TXNL4B with chemical compounds

  • All DIM amide nitrogens donate hydrogen bonds to N and O atoms on the floor of the DNA groove and, in addition, the two Im rings on DIM2 accept hydrogen bonds from guanine N2 amines, thereby providing specific reading [14].
  • In our current study, we investigated steady-state ras transcript expression at the earliest recognized stages of sex steroid-induced dysplasia in the DLP [15].
  • DLP was the superior regimen in subsets of patients receiving cisplatin and the non-cisplatin chemotherapy [16].
  • BACKGROUND: The simultaneous treatment of intact Noble rats with testosterone and estradiol-17 beta for 16 weeks consistently induces intraductal dysplasia exclusively in the dorsolateral lobe (DLP) of the prostate [15].
  • To define further the place of dexamethasone in antiemetic combinations, lorazepam, prochlorperazine and placebo (LP) were compared with lorazepam, prochlorperazine and dexamethasone (DLP) in a randomised, double-blind, crossover study [16].

Other interactions of TXNL4B

  • Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2 [17].
  • The crystallographic structure of hDim2 solved at 2.5 A reveals a classical thioredoxin-fold structure [17].
  • The structure of hDim2 contains an extra alpha helix (alpha3) and a beta strand (beta5), which stabilize the protein, suggesting that they may be involved in interactions with hDim2-specific partners [17].

Analytical, diagnostic and therapeutic context of TXNL4B

  • Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B [4].
  • The stability and thermodynamic parameters of hDim2 were evaluated by combining circular dichroism and fluorescence spectroscopy together with chromatographic and cross-linking approaches [17].
  • Patients documented significantly improved tolerance to chemotherapy with DLP courses (P = 0.0006) [16].
  • In situ hybridization revealed markedly enhanced H-ras expression in some dysplastic DLP foci and no changes in histologically normal ducts and acini [15].
  • Sufficient expansion can be achieved using the DLPP cytokine combination in the Cell Factories to provide the numbers of progenitors required for clinical trials [11].


  1. Evaluation and management of dyslipoproteinemia in children. Franklin, F.A., Dashti, N., Franklin, C.C. Endocrinol. Metab. Clin. North Am. (1998) [Pubmed]
  2. Primary small intestinal lymphoma in adults. A comparative study of IPSID versus non-IPSID in the Middle East. Salem, P., el-Hashimi, L., Anaissie, E., Geha, S., Habboubi, N., Ibrahim, N., Khalyl, M., Allam, C. Cancer (1987) [Pubmed]
  3. Which factors predict upper urinary tract deterioration in overactive neurogenic bladder dysfunction? Ozkan, B., Demirkesen, O., Durak, H., Uygun, N., Ismailoglu, V., Cetinel, B. Urology (2005) [Pubmed]
  4. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. Jin, T., Howard, A.J., Golemis, E.A., Wang, Y., Zhang, Y.Z. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  5. Early detection of distal symmetrical polyneuropathy during HIV infection by paired stimulation of sural nerve. Husstedt, I.W., Grotemeyer, K.H., Busch, H., Zidek, W. Electroencephalography and clinical neurophysiology. (1994) [Pubmed]
  6. Home-based versus hospital-based care for people with serious mental illness. Marks, I.M., Connolly, J., Muijen, M., Audini, B., McNamee, G., Lawrence, R.E. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  7. DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. Sun, X., Zhang, H., Wang, D., Ma, D., Shen, Y., Shang, Y. J. Biol. Chem. (2004) [Pubmed]
  8. Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest. Chanez, A.L., Hehl, A.B., Engstler, M., Schneider, A. J. Cell. Sci. (2006) [Pubmed]
  9. Comparison of stable-isotope-tracer methods for the determination of magnesium absorption in humans. Sabatier, M., Keyes, W.R., Pont, F., Arnaud, M.J., Turnlund, J.R. Am. J. Clin. Nutr. (2003) [Pubmed]
  10. Is it possible to use urodynamic variables to predict upper urinary tract dilatation in children with neurogenic bladder-sphincter dysfunction? Wang, Q.W., Wen, J.G., Song, D.K., Su, J., Che, Y.Y., Zhang, P., Du, A.M., Wang, D.X., Zhu, Q.H., Wei, J.X. BJU Int. (2006) [Pubmed]
  11. Clinical-scale production of granulocyte progenitor and post-progenitor cells using daniplestim, leridistim, Progenipoietin, Promegapoietin and autologous plasma. Patel, S.D., Guo, R., Miller, W.M., Papoutsakis, E.T., Minster, N.I., Baum, C.M., Winter, J.N. Cytotherapy. (2000) [Pubmed]
  12. A second ascending visual pathway from the optic tectum to the telencephalon in the pigeon (Columba livia). Gamlin, P.D., Cohen, D.H. J. Comp. Neurol. (1986) [Pubmed]
  13. Optimal delivery of cardioplegic solution for "redo" operations. Gundry, S.R., Razzouk, A.J., Vigesaa, R.E., Wang, N., Bailey, L.L. J. Thorac. Cardiovasc. Surg. (1992) [Pubmed]
  14. Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. Kopka, M.L., Goodsell, D.S., Han, G.W., Chiu, T.K., Lown, J.W., Dickerson, R.E. Structure (1997) [Pubmed]
  15. Early alterations in ras protooncogene mRNA expression in testosterone and estradiol-17 beta induced prostatic dysplasia of noble rats. Yu, M., Leav, B.A., Leav, I., Merk, F.B., Wolfe, H.J., Ho, S.M. Lab. Invest. (1993) [Pubmed]
  16. A randomised trial of dexamethasone, lorazepam and prochlorperazine for emesis in patients receiving chemotherapy. Bishop, J.F., Matthews, J.P., Wolf, M.M., Oliver, I.N., Reynolds, S., Walpole, E., Rischin, D., Buchanan, L., Tan, L.G. Eur. J. Cancer (1992) [Pubmed]
  17. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. Simeoni, F., Arvai, A., Bello, P., Gondeau, C., Hopfner, K.P., Neyroz, P., Heitz, F., Tainer, J., Divita, G. Biochemistry (2005) [Pubmed]
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