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Gene Review

SLC47A1  -  solute carrier family 47 (multidrug and...

Homo sapiens

Synonyms: FLJ10847, MATE-1, MATE1, Multidrug and toxin extrusion protein 1, Solute carrier family 47 member 1, ...
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Disease relevance of SLC47A1

  • The purpose of this study is to review the literature and discuss the role of Maté consumption in the development of oral and oropharyngeal cancer and the potential carcinogenic mechanisms [1].
  • Only Soft Mate disinfected Serratia marcescens within 4 hours [2].
  • AIMS: This study had two distinct aims: to determine the effect of a herbal preparation 'YGD' containing Yerbe Maté, Guarana and Damiana on gastric emptying; to determine the effect of the same preparation on weight loss over 10 days and 45 days and weight maintenance over 12 months [3].

Psychiatry related information on SLC47A1


High impact information on SLC47A1

  • The immunohistochemical analyses revealed that the hMATE2-K as well as the hMATE1 was localized at the brush border membranes of the proximal tubules [5].
  • The hMATE2-K cDNA had an open reading frame that encodes a 566-amino acid protein, which shows 94, 82, 52, and 52% identity with the hMATE2, hMATE2-B, hMATE1, and rat MATE1, respectively [5].
  • Functional characterization suggested that an oppositely directed H(+) gradient serves as a driving force for the transport of a prototypical organic cation, tetraethylammonium, by MATE1, but there is no direct evidence to prove this [6].
  • Recently, we have isolated the rat (r) H(+)/organic cation antiporter multidrug and toxin extrusion 1 (MATE1) and reported its tissue distribution and transport characteristics [6].
  • The hMATE1 and hMATE2-K, but not hOCTN1 and OCTN2, mediated the cellular accumulation of cisplatin and oxaliplatin without a marked release of lactate dehydrogenase [7].

Biological context of SLC47A1

  • Upon expression of this protein in HEK-293 cells, mMATE1 mediated electroneutral H(+)/tetraethylammonium exchange and showed a substrate specificity similar to that of hMATE1 [8].
  • Superparasitism and sex ratio adjustment in a wasp parasitoid: results at variance with Local Mate Competition [9]?
  • We then present evidence suggesting substantial sex differences in the following domains of sexual behavior: Mate preferences, interest in casual sex, interest in partner variety, jealousy, fantasy, sexual "plasticity," and magnitude of intrinsic sexual motivation [10].
  • REVIEW. Female Mate Value at a Glance: Relationship of Waist-to-Hip Ratio to Health, Fecundity and Attractiveness [11].
  • For the fungal species, Soft Mate showed excellent activity against Candida albicans (disinfection in 4 hours) and reduced Aspergillus fumigatus to 10(3) spores/mL in 4 hours [2].

Anatomical context of SLC47A1

  • There is evidence in the literature that Maté consumption is in itself carcinogenic and plays a role in the development of cancers of the oral cavity and oropharynx [1].

Associations of SLC47A1 with chemical compounds

  • However, the inhibitory effect of cisplatin and oxaliplatin against the hMATE1-mediated TEA uptake was similar [7].
  • Determination of cocaine in "Mate de Coca" herbal tea [12].
  • The tablets 1 (one hour before meals, comprises extracts of Asparagus, Green tea, Black tea, Guarana, Mate and Kidney beans) and 2 (taken half an hour after meals, comprises extracts of Kidney bean pods, Garcinia cambogia, and Chromium yeast) are taken twice daily with two main meals [13].

Analytical, diagnostic and therapeutic context of SLC47A1

  • Keywords: Mate tea leaves (Ilex paraguariensis); hot water infusion process; elemental composition; PIXE [14].
  • An improved Bullard laryngoscope holder: Bullard Mate version 2 [15].
  • Group A had the endotracheal tube or tracheostomy cuff inflated randomly by a syringe and tested later by the Cuff Mate [16].
  • This study suggests that high-risk fallers transferring to or from manual wheelchairs sustained significantly fewer falls when the Steddy Mate automatic braking system for manual wheelchairs was installed [17].
  • Case control studies on Maté drinking populations and, in vivo and in vitro studies on the carcinogenicity of Maté were reviewed [1].


  1. Maté: a risk factor for oral and oropharyngeal cancer. Goldenberg, D. Oral Oncol. (2002) [Pubmed]
  2. Disinfecting activities of non-peroxide soft contact lens cold disinfection solutions. Shih, K.L., Raad, M.K., Hu, J.C., Gresh, W.J., Jiries, S.I., Caldwell, L.J., Bergamini, M.V. The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc. (1991) [Pubmed]
  3. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. Andersen, T., Fogh, J. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. (2001) [Pubmed]
  4. Self-esteem and stress as factors in abuse of children. Lawson, K.A., Hays, J.R. Psychological reports. (1989) [Pubmed]
  5. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. Masuda, S., Terada, T., Yonezawa, A., Tanihara, Y., Kishimoto, K., Katsura, T., Ogawa, O., Inui, K. J. Am. Soc. Nephrol. (2006) [Pubmed]
  6. Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1. Tsuda, M., Terada, T., Asaka, J., Ueba, M., Katsura, T., Inui, K. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  7. Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1-3 and Multidrug and Toxin Extrusion Family). Yonezawa, A., Masuda, S., Yokoo, S., Katsura, T., Inui, K. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  8. Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations. Hiasa, M., Matsumoto, T., Komatsu, T., Moriyama, Y. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  9. Superparasitism and sex ratio adjustment in a wasp parasitoid: results at variance with Local Mate Competition? Santolamazza-Carbone, S., Cordero Rivera, A. Oecologia (2003) [Pubmed]
  10. Human sex differences in sexual psychology and behavior. Okami, P., Shackelford, T.K. Annual review of sex research. (2001) [Pubmed]
  11. REVIEW. Female Mate Value at a Glance: Relationship of Waist-to-Hip Ratio to Health, Fecundity and Attractiveness. Singh, D. Neuro Endocrinol. Lett. (2002) [Pubmed]
  12. Determination of cocaine in "Mate de Coca" herbal tea. Engelke, B.F., Gentner, W.A. Journal of pharmaceutical sciences. (1991) [Pubmed]
  13. Efficacy of 12 Weeks Supplementation of a Botanical Extract-based Weight Loss Formula on Body Weight, Body Composition and Blood Chemistry in Healthy, Overweight Subjects - A Randomised Double-blind Placebo-controlled Clinical Trial. Opala, T., Rzymski, P., Pischel, I., Wilczak, M., Wozniak, J. Eur. J. Med. Res. (2006) [Pubmed]
  14. Elemental Characterization of Commercial Mate Tea Leaves (Ilex paraguariensis A. St.-Hil.) before and after Hot Water Infusion Using Ion Beam Techniques. Giulian, R., Santos, C.E., Shubeita, S.d.e. .M., Silva, L.M., Dias, J.F., Yoneama, M.L. J. Agric. Food Chem. (2007) [Pubmed]
  15. An improved Bullard laryngoscope holder: Bullard Mate version 2. Tada, T., Amagasa, S., Horikawa, H. Journal of anesthesia. (2002) [Pubmed]
  16. Anesthesia apparatus: Cuff Mate-2, endotracheal cuff inflator and pressure monitor. Swaiss, I., Badran, I. Middle East journal of anesthesiology. (2003) [Pubmed]
  17. Effectiveness of an automatic manual wheelchair braking system in the prevention of falls. Martorello, L., Swanson, E. Assistive technology : the official journal of RESNA (2006) [Pubmed]
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