Disease relevance of PTPN4

• RESULTS: PTPN3 and PTPN4 were expressed in all gastric cancer cell lines and clinical cancer tissue specimens examined [1].
• PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma [1].
• The influence of brain tumor treatment on pathological delta activity in MEG [2].
• FFA is shown to track complex dynamics of synchrony in coupled oscillator models, reveal the time-frequency and spatial dynamics of synchrony convergence and divergence in epileptic seizures, and in MEG data the large-scale ongoing dynamics of synchrony correlated with conscious perception during binocular rivalry [3].
• MEG data were acquired from a group of relapsing-remitting multiple sclerosis (MS) patients and a group of healthy controls, using an eyes-closed no-task condition [4].

Psychiatry related information on PTPN4

• Studying metabolic, endocrine, and gastrointestinal (MEG) disorders in drug abuse and HIV infection is important [5].
• We conclude that an increase in fast MEG activity in the auditory cortex is a neurophysiologic correlate for auditory hallucinations in schizophrenia [6].
• Neuropsychological test results were significant despite the fact that the patient's recent MRI and MEG were within normal limits [7].
• The influence of sleep deprivation (SD) on event-related fields and the distribution of power over the scalp of MEG imaged brain activity was studied during acoustically paced rhythmic force production [8].
• In this longitudinal study multichannel MEG was used to localize and to quantify focal pathological spontaneous neuromagnetic activity in six patients with transient ischemic attacks (TIA) and two patients with transient global amnesia (TGA) [9].

High impact information on PTPN4

• Endogenous PTPMEG accounts for only 1/3000th of the total tyrosine phosphatase activity in COS-7 cells and transfected cells expressed 2- to 7-fold higher levels of the enzyme [10].
• These results indicate that in COS-7 cells both PTPMEG and PTPMEGCS inhibit cell proliferation, reduce the saturation density, and block the ability of these cells to grow without adhering to a solid matrix [10].
• The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells [10].
• We established stable COS-7 cell lines overexpressing recombinant PTPMEG and an inactive mutant form in which the active site cysteine is mutated to serine (PTPMEGCS) [10].
• We screened human megakaryoblastic cell line (MEG-01) an umbilical vein endothelial cell cDNA libraries to obtain a 3.7-kilobase cDNA designated PTPase MEG [11].

Biological context of PTPN4

• PTPase MEG cDNA contains an open reading frame of 926 amino acids [11].
• We previously cloned a cDNA encoding a protein tyrosine phosphatase (PTP) containing sequence homology to protein 4.1, designated PTPMEG [12].
• Under these conditions, we then assessed whether motion areas of cortex were still able to process the motion stimuli by recording event-related potentials (ERPs) and event-related magnetic fields (ERFs/MEG) [13].
• We show that the whole spectrum of MEG/EEG signals can be reproduced within the oscillatory regime of this model by simply changing the population kinetics [14].
• Both simulated MEG data and data from a visual evoked response experiment are used to demonstrate the capabilities of this approach [15].

Anatomical context of PTPN4

• Both constructs inhibited the ability of COS-7 cells to form colonies in soft agar, with the native PTPMEG having a greater effect (30-fold) than PTPMEGCS (10-fold) [10].
• Here, we showed by in situ hybridization analysis that the PTPMEG mRNA was enriched in mouse thalamus and Purkinje cells [16].
• The number of MEG-CFC in the bone marrow of rhIL-11-treated, splenectomized mice was increased twofold compared with controls on both days 3 and 7 of the study [17].
• Megakaryocyte numbers in bone marrow and spleen were elevated, as were bone marrow and spleen megakaryocyte colony-forming cells (MEG-CFC) [18].
• We examined the contralateral hemispheric cortical activity in MEG (151 ch) after unilateral median nerve stimulation of the right and left hand in twenty healthy right-handed subjects [19].

Associations of PTPN4 with chemical compounds

• The properties of the protein tyrosine phosphatase PTPMEG [12].
• Similar to purification of Epo, ethanol precipitation and sulfopropyl-Sephadex chromatography provided twofold and threefold increases in the specific activity of MEG-CSF, respectively [20].
• The elution profile of MEG-CSF seen on hydroxylapatite chromatography of urinary extracts was different from that of Epo [20].
• GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam [21].
• Serotonin modulates early cortical auditory processing in healthy subjects: evidence from MEG with acute tryptophan depletion [22].

Regulatory relationships of PTPN4

• CONCLUSION: This finding indicates that both PTPN3 and PTPN4 are expressed within human gastric cancer cells and that PTPN3 seems to play an important role in gastric cancer differentiation and the progression of malignancy [1].

Analytical, diagnostic and therapeutic context of PTPN4

• Images of conflict: MEG vs. EEG [23].
• This preview discusses recent fMRI and MEG data from Gonsalves et al [24].
• In this paper, we present a novel approach to imaging sparse and focal neural current sources from MEG (magnetoencephalography) data [25].
• With the advent of non-invasive imaging techniques such as MEG (magnetoencephalogram) and functional MRI, topographical reorganization can also be demonstrated in humans, so that it is now possible to track perceptual changes and changes in cortical topography in individual patients [26].
• We measured the MEG signal following electrical stimulation of upper and lower limbs in two normal and three clinically complete paraplegic subjects [27].

References