The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PTPN4  -  protein tyrosine phosphatase, non-receptor...

Homo sapiens

Synonyms: MEG, PTPMEG, PTPMEG1, PTPase-MEG1, Protein-tyrosine phosphatase MEG1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PTPN4

  • RESULTS: PTPN3 and PTPN4 were expressed in all gastric cancer cell lines and clinical cancer tissue specimens examined [1].
  • PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma [1].
  • The influence of brain tumor treatment on pathological delta activity in MEG [2].
  • FFA is shown to track complex dynamics of synchrony in coupled oscillator models, reveal the time-frequency and spatial dynamics of synchrony convergence and divergence in epileptic seizures, and in MEG data the large-scale ongoing dynamics of synchrony correlated with conscious perception during binocular rivalry [3].
  • MEG data were acquired from a group of relapsing-remitting multiple sclerosis (MS) patients and a group of healthy controls, using an eyes-closed no-task condition [4].

Psychiatry related information on PTPN4


High impact information on PTPN4


Biological context of PTPN4

  • PTPase MEG cDNA contains an open reading frame of 926 amino acids [11].
  • We previously cloned a cDNA encoding a protein tyrosine phosphatase (PTP) containing sequence homology to protein 4.1, designated PTPMEG [12].
  • Under these conditions, we then assessed whether motion areas of cortex were still able to process the motion stimuli by recording event-related potentials (ERPs) and event-related magnetic fields (ERFs/MEG) [13].
  • We show that the whole spectrum of MEG/EEG signals can be reproduced within the oscillatory regime of this model by simply changing the population kinetics [14].
  • Both simulated MEG data and data from a visual evoked response experiment are used to demonstrate the capabilities of this approach [15].

Anatomical context of PTPN4

  • Both constructs inhibited the ability of COS-7 cells to form colonies in soft agar, with the native PTPMEG having a greater effect (30-fold) than PTPMEGCS (10-fold) [10].
  • Here, we showed by in situ hybridization analysis that the PTPMEG mRNA was enriched in mouse thalamus and Purkinje cells [16].
  • The number of MEG-CFC in the bone marrow of rhIL-11-treated, splenectomized mice was increased twofold compared with controls on both days 3 and 7 of the study [17].
  • Megakaryocyte numbers in bone marrow and spleen were elevated, as were bone marrow and spleen megakaryocyte colony-forming cells (MEG-CFC) [18].
  • We examined the contralateral hemispheric cortical activity in MEG (151 ch) after unilateral median nerve stimulation of the right and left hand in twenty healthy right-handed subjects [19].

Associations of PTPN4 with chemical compounds

  • The properties of the protein tyrosine phosphatase PTPMEG [12].
  • Similar to purification of Epo, ethanol precipitation and sulfopropyl-Sephadex chromatography provided twofold and threefold increases in the specific activity of MEG-CSF, respectively [20].
  • The elution profile of MEG-CSF seen on hydroxylapatite chromatography of urinary extracts was different from that of Epo [20].
  • GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam [21].
  • Serotonin modulates early cortical auditory processing in healthy subjects: evidence from MEG with acute tryptophan depletion [22].

Regulatory relationships of PTPN4


Analytical, diagnostic and therapeutic context of PTPN4

  • Images of conflict: MEG vs. EEG [23].
  • This preview discusses recent fMRI and MEG data from Gonsalves et al [24].
  • In this paper, we present a novel approach to imaging sparse and focal neural current sources from MEG (magnetoencephalography) data [25].
  • With the advent of non-invasive imaging techniques such as MEG (magnetoencephalogram) and functional MRI, topographical reorganization can also be demonstrated in humans, so that it is now possible to track perceptual changes and changes in cortical topography in individual patients [26].
  • We measured the MEG signal following electrical stimulation of upper and lower limbs in two normal and three clinically complete paraplegic subjects [27].


  1. PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma. Wu, C.W., Chen, J.H., Kao, H.L., Li, A.F., Lai, C.H., Chi, C.W., Lin, W.C. Anticancer Res. (2006) [Pubmed]
  2. The influence of brain tumor treatment on pathological delta activity in MEG. de Jongh, A., Baayen, J.C., de Munck, J.C., Heethaar, R.M., Vandertop, W.P., Stam, C.J. Neuroimage (2003) [Pubmed]
  3. Frequency flows and the time-frequency dynamics of multivariate phase synchronization in brain signals. Rudrauf, D., Douiri, A., Kovach, C., Lachaux, J.P., Cosmelli, D., Chavez, M., Adam, C., Renault, B., Martinerie, J., Le Van Quyen, M. Neuroimage (2006) [Pubmed]
  4. Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG. Cover, K.S., Vrenken, H., Geurts, J.J., van Oosten, B.W., Jelles, B., Polman, C.H., Stam, C.J., van Dijk, B.W. Neuroimage (2006) [Pubmed]
  5. Nutritional assessment in intravenous drug users with HIV/AIDS. Smit, E., Tang, A. J. Acquir. Immune Defic. Syndr. (2000) [Pubmed]
  6. Cortical activity associated with auditory hallucinations. Ropohl, A., Sperling, W., Elstner, S., Tomandl, B., Reulbach, U., Kaltenhäuser, M., Kornhuber, J., Maihöfner, C. Neuroreport (2004) [Pubmed]
  7. Neurodevelopmental outcome for extended cold water drowning: a longitudinal case study. Hughes, S.K., Nilsson, D.E., Boyer, R.S., Bolte, R.G., Hoffman, R.O., Lewine, J.D., Bigler, E.D. Journal of the International Neuropsychological Society : JINS. (2002) [Pubmed]
  8. Effects of sleep deprivation on event-related fields and alpha activity during rhythmic force production. Boonstra, T.W., Daffertshofer, A., Beek, P.J. Neurosci. Lett. (2005) [Pubmed]
  9. Time course of focal slow wave activity in transient ischemic attacks and transient global amnesia as measured by magnetoencephalography. Stippich, C., Kassubek, J., Kober, H., Sörŏs, P., Vieth, J.B. Neuroreport (2000) [Pubmed]
  10. The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells. Gu, M., Meng, K., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Gu, M.X., York, J.D., Warshawsky, I., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  12. The properties of the protein tyrosine phosphatase PTPMEG. Gu, M., Majerus, P.W. J. Biol. Chem. (1996) [Pubmed]
  13. Unmasking motion-processing activity in human brain area V5/MT+ mediated by pathways that bypass primary visual cortex. Schoenfeld, M.A., Heinze, H.J., Woldorff, M.G. Neuroimage (2002) [Pubmed]
  14. A neural mass model for MEG/EEG: coupling and neuronal dynamics. David, O., Friston, K.J. Neuroimage (2003) [Pubmed]
  15. Bayesian inference applied to the electromagnetic inverse problem. Schmidt, D.M., George, J.S., Wood, C.C. Human brain mapping. (1999) [Pubmed]
  16. The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits. Hironaka, K., Umemori, H., Tezuka, T., Mishina, M., Yamamoto, T. J. Biol. Chem. (2000) [Pubmed]
  17. Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice. Neben, T.Y., Loebelenz, J., Hayes, L., McCarthy, K., Stoudemire, J., Schaub, R., Goldman, S.J. Blood (1993) [Pubmed]
  18. Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. Zhou, W., Toombs, C.F., Zou, T., Guo, J., Robinson, M.O. Blood (1997) [Pubmed]
  19. Whole-head MEG analysis of cortical spatial organization from unilateral stimulation of median nerve in both hands: no complete hemispheric homology. Theuvenet, P.J., van Dijk, B.W., Peters, M.J., van Ree, J.M., Lopes da Silva, F.L., Chen, A.C. Neuroimage (2005) [Pubmed]
  20. Characterization of human megakaryocyte colony-stimulating factor in the urinary extracts from patients with aplastic anemia and idiopathic thrombocytopenic purpura. Kawakita, M., Ogawa, M., Goldwasser, E., Miyake, T. Blood (1983) [Pubmed]
  21. GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam. Northoff, G., Witzel, T., Richter, A., Gessner, M., Schlagenhauf, F., Fell, J., Baumgart, F., Kaulisch, T., Tempelmann, C., Heinzel, A., Kötter, R., Hagner, T., Bargel, B., Hinrichs, H., Bogerts, B., Scheich, H., Heinze, H.J. Journal of cognitive neuroscience. (2002) [Pubmed]
  22. Serotonin modulates early cortical auditory processing in healthy subjects: evidence from MEG with acute tryptophan depletion. Kähkönen, S., Ahveninen, J., Pennanen, S., Liesivuori, J., Ilmoniemi, R.J., Jääskeläinen, I.P. Neuropsychopharmacology (2002) [Pubmed]
  23. Images of conflict: MEG vs. EEG. Crease, R.P. Science (1991) [Pubmed]
  24. Less is more: how reduced activity reflects stronger recognition. Stern, C.E., Hasselmo, M.E. Neuron (2005) [Pubmed]
  25. Controlled Support MEG imaging. Nagarajan, S.S., Portniaguine, O., Hwang, D., Johnson, C., Sekihara, K. Neuroimage (2006) [Pubmed]
  26. The perception of phantom limbs. The D. O. Hebb lecture. Ramachandran, V.S., Hirstein, W. Brain (1998) [Pubmed]
  27. Brain activation sequences following electrical limb stimulation of normal and paraplegic subjects. Ioannides, A.A., Liu, L., Khurshudyan, A., Bodley, R., Poghosyan, V., Shibata, T., Dammers, J., Jamous, A. Neuroimage (2002) [Pubmed]
WikiGenes - Universities