Gene Review:
HAMP - hepcidin antimicrobial peptide
Homo sapiens
Synonyms:
HEPC, HFE2B, Hepcidin, LEAP-1, LEAP1, ...
Thompson,
Beris,
Michel,
Samuels,
Rubbia-Brandt,
Donatella Barisani,
Sara Pelucchi,
Raffaella Mariani,
Stefania Galimberti,
Paola Trombini,
Daniela Fumagalli,
Raffaella Meneveri,
Elizabeta Nemeth,
Tomas Ganz,
Alberto Piperno,
Aguilar-Martinez,
Goldberg,
Hayden,
Gow,
Allen,
MacFarlane,
Ganz,
Darbellay,
Matthes,
Radomski,
Giostra,
Delatycki,
Pizzi-Bosman,
- Hepcidin in iron overload disorders. Papanikolaou, G., Tzilianos, M., Christakis, J.I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y.P., Sakellaropoulos, N., Ganz, T., Nemeth, E. Blood (2005)
- Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Gehrke, S.G., Herrmann, T., Kulaksiz, H., Merle, U., Bents, K., Kaiser, I., Riedel, H.D., Stremmel, W. Digestion (2005)
- Anemia of inflammation: the hepcidin link. Roy, C.N., Andrews, N.C. Curr. Opin. Hematol. (2005)
- The HAMP Domain Structure Implies Helix Rotation in Transmembrane Signaling. Hulko, M., Berndt, F., Gruber, M., Linder, J.U., Truffault, V., Schultz, A., Martin, J., Schultz, J.E., Lupas, A.N., Coles, M. Cell (2006)
- LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. Krause, A., Neitz, S., Mägert, H.J., Schulz, A., Forssmann, W.G., Schulz-Knappe, P., Adermann, K. FEBS Lett. (2000)
- Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. Barisani, D., Pelucchi, S., Mariani, R., Galimberti, S., Trombini, P., Fumagalli, D., Meneveri, R., Nemeth, E., Ganz, T., Piperno, A. J. Hepatol. (2008)
- Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nicolas, G., Viatte, L., Lou, D.Q., Bennoun, M., Beaumont, C., Kahn, A., Andrews, N.C., Vaulont, S. Nat. Genet. (2003)
- Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Theurl, I., Mattle, V., Seifert, M., Mariani, M., Marth, C., Weiss, G. Blood (2006)
- Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP gene. Matthes, T., Aguilar-Martinez, P., Pizzi-Bosman, L., Darbellay, R., Rubbia-Brandt, L., Giostra, E., Michel, M., Ganz, T., Beris, P. Blood (2004)
- HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. Jacolot, S., Le Gac, G., Scotet, V., Quere, I., Mura, C., Ferec, C. Blood (2004)
- The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Lee, P., Peng, H., Gelbart, T., Beutler, E. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Bridle, K.R., Frazer, D.M., Wilkins, S.J., Dixon, J.L., Purdie, D.M., Crawford, D.H., Subramaniam, V.N., Powell, L.W., Anderson, G.J., Ramm, G.A. Lancet (2003)
- Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Merryweather-Clarke, A.T., Cadet, E., Bomford, A., Capron, D., Viprakasit, V., Miller, A., McHugh, P.J., Chapman, R.W., Pointon, J.J., Wimhurst, V.L., Livesey, K.J., Tanphaichitr, V., Rochette, J., Robson, K.J. Hum. Mol. Genet. (2003)
- A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis. Delatycki, M.B., Allen, K.J., Gow, P., MacFarlane, J., Radomski, C., Thompson, J., Hayden, M.R., Goldberg, Y.P., Samuels, M.E. Clin. Genet. (2004)
- Regulatory effects of tumor necrosis factor-alpha and interleukin-6 on HAMP expression in iron loaded rat hepatocytes. Dzikaite, V., Holmström, P., Stål, P., Eckes, K., Hagen, K., Eggertsen, G., Gåfvels, M., Melefors, O., Hultcrantz, R. J. Hepatol. (2006)
- Hepcidin expression and iron transport in alveolar macrophages. Nguyen, N.B., Callaghan, K.D., Ghio, A.J., Haile, D.J., Yang, F. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- The spectrum of antimicrobial peptide expression at the ocular surface. McIntosh, R.S., Cade, J.E., Al-Abed, M., Shanmuganathan, V., Gupta, R., Bhan, A., Tighe, P.J., Dua, H.S. Invest. Ophthalmol. Vis. Sci. (2005)
- Regulation of transepithelial transport of iron by hepcidin. Mena, N.P., Esparza, A.L., Núñez, M.T. Biol. Res. (2006)
- Genetic analysis of the HAMP domain of the Aer aerotaxis sensor localizes flavin adenine dinucleotide-binding determinants to the AS-2 helix. Ma, Q., Johnson, M.S., Taylor, B.L. J. Bacteriol. (2005)
- The evaluation of hyperferritinemia: an updated strategy based on advances in detecting genetic abnormalities. Aguilar-Martinez, P., Schved, J.F., Brissot, P. Am. J. Gastroenterol. (2005)
- Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., Camaschella, C. Nat. Genet. (2003)
- C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. Courselaud, B., Pigeon, C., Inoue, Y., Inoue, J., Gonzalez, F.J., Leroyer, P., Gilot, D., Boudjema, K., Guguen-Guillouzo, C., Brissot, P., Loréal, O., Ilyin, G. J. Biol. Chem. (2002)
- Clinical reliability of the "furcation arrow" as a diagnostic marker. Deas, D.E., Moritz, A.J., Mealey, B.L., McDonnell, H.T., Powell, C.A. J. Periodontol. (2006)
- Partial liver transplantation from a living donor: experimental research and clinical experience. Kawarasaki, H., Iwanaka, T., Tsuchida, Y., Kanamori, Y., Tanaka, K., Utsuki, T., Komuro, H., Chen, C.L., Kawasaki, S., Ishizone, S. J. Pediatr. Surg. (1994)