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Gene Review

Phgdh  -  phosphoglycerate dehydrogenase

Rattus norvegicus

Synonyms: 3-PGDH, D-3-phosphoglycerate dehydrogenase
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Disease relevance of Phgdh


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Biological context of Phgdh


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Associations of Phgdh with chemical compounds


Analytical, diagnostic and therapeutic context of Phgdh


  1. Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase. Achouri, Y., Rider, M.H., Schaftingen, E.V., Robbi, M. Biochem. J. (1997) [Pubmed]
  2. D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. Dey, S., Hu, Z., Xu, X.L., Sacchettini, J.C., Grant, G.A. J. Biol. Chem. (2005) [Pubmed]
  3. Enzymic imbalance in serine metabolism in rat hepatomas. Snell, K., Weber, G. Biochem. J. (1986) [Pubmed]
  4. Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Snell, K., Natsumeda, Y., Eble, J.N., Glover, J.L., Weber, G. Br. J. Cancer (1988) [Pubmed]
  5. L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. Furuya, S., Tabata, T., Mitoma, J., Yamada, K., Yamasaki, M., Makino, A., Yamamoto, T., Watanabe, M., Kano, M., Hirabayashi, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Synthesis and release of L-serine by rat astroglia-rich primary cultures. Verleysdonk, S., Hamprecht, B. Glia (2000) [Pubmed]
  7. Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liver. Achouri, Y., Robbi, M., Van Schaftingen, E. Biochem. J. (1999) [Pubmed]
  8. Selective expression of L-serine synthetic enzyme 3PGDH in schwann cells, perineuronal glia, and endoneurial fibroblasts along rat sciatic nerves and its upregulation after crush injury. Yamashita, N., Sakai, K., Furuya, S., Watanabe, M. Arch. Histol. Cytol. (2003) [Pubmed]
  9. L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate dehydrogenase, an enzyme for L-Serine biosynthesis. Sugishita, H., Kuwabara, Y., Toku, K., Doi, L., Yang, L., Mitoma, J., Furuya, S., Hirabayashi, Y., Maeda, N., Sakanaka, M., Tanaka, J. J. Neurosci. Res. (2001) [Pubmed]
  10. Regulation of enzymes of serine and one-carbon metabolism by testosterone in rat prostate, liver, and kidney. Sanborn, T.A., Kowle, R.L., Sallach, H.J. Endocrinology (1975) [Pubmed]
  11. The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rat liver in vivo. Guynn, R.W., Merrill, D.K., Lund, K. Arch. Biochem. Biophys. (1986) [Pubmed]
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