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Gene Review

SCTR  -  secretin receptor

Homo sapiens

Synonyms: SCT-R, Secretin receptor
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Disease relevance of SCTR


High impact information on SCTR


Chemical compound and disease context of SCTR


Biological context of SCTR


Anatomical context of SCTR


Associations of SCTR with chemical compounds


Physical interactions of SCTR


Other interactions of SCTR


Analytical, diagnostic and therapeutic context of SCTR


  1. Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. K??rner, M., Hayes, G.M., Rehmann, R., Zimmermann, A., Scholz, A., Wiedenmann, B., Miller, L.J., Reubi, J.C. J. Hepatol. (2006) [Pubmed]
  2. Molecular cloning and functional characterization of a human secretin receptor. Chow, B.K. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  3. Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma. Ding, W.Q., Kuntz, S., Böhmig, M., Wiedenmann, B., Miller, L.J. Gastroenterology (2002) [Pubmed]
  4. Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. Long, S.H., Berna, M.J., Thill, M., Pace, A., Pradhan, T.K., Hoffmann, K.M., Serrano, J., Jensen, R.T. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  5. A novel secretin receptor splice variant potentially useful for early diagnosis of pancreatic carcinoma. Hayes, G.M., Carrigan, P.E., Dong, M., Reubi, J.C., Miller, L.J. Gastroenterology (2007) [Pubmed]
  6. Effect of cholecystokinin and secretin on somatostatin release from cultured antral cells. Buchan, A.M., Meloche, R.M., Kwok, Y.N., Kofod, H. Gastroenterology (1993) [Pubmed]
  7. Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma. Ding, W.Q., Cheng, Z.J., McElhiney, J., Kuntz, S.M., Miller, L.J. Cancer Res. (2002) [Pubmed]
  8. Failure of secretin to stimulate gastrin release and adenylate cyclase activity in gastrinoma in vitro. Ellison, E.C., O'Dorisio, M.S., O'Dorisio, T., Sparks, J., Vasallo, L., Woltering, E.A. Surgery (1984) [Pubmed]
  9. A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. Shetzline, M.A., Premont, R.T., Walker, J.K., Vigna, S.R., Caron, M.G. J. Biol. Chem. (1998) [Pubmed]
  10. CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene. Pang, R.T., Lee, L.T., Ng, S.S., Yung, W.H., Chow, B.K. Mol. Endocrinol. (2004) [Pubmed]
  11. Role of N-linked glycosylation on the function and expression of the human secretin receptor. Pang, R.T., Ng, S.S., Cheng, C.H., Holtmann, M.H., Miller, L.J., Chow, B.K. Endocrinology (1999) [Pubmed]
  12. Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry. Mark, H.F., Chow, B.K. Genomics (1995) [Pubmed]
  13. Molecular cloning and functional expression of a human pancreatic secretin receptor. Jiang, S., Ulrich, C. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  14. Expression and spatial distribution of secretin and secretin receptor in human cerebellum. Lee, S.M., Yung, W.H., Chen, L., Chow, B.K. Neuroreport (2005) [Pubmed]
  15. Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. Walker, J.K., Premont, R.T., Barak, L.S., Caron, M.G., Shetzline, M.A. J. Biol. Chem. (1999) [Pubmed]
  16. Real-time evaluation of human secretin receptor activity using cytosensor microphysiometry. Ng, S.S., Pang, R.T., Chow, B.K., Cheng, C.H. J. Cell. Biochem. (1999) [Pubmed]
  17. The prenatal expression of secretin receptor. Siu, F.K., Sham, M.H., Chow, B.K. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  18. Secretin receptors on neuroblastoma cell membranes: characterization of 125I-labeled secretin binding and association with adenylate cyclase. Roth, B.L., Beinfeld, M.C., Howlett, A.C. J. Neurochem. (1984) [Pubmed]
  19. Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin. Vilardaga, J.P., di Paolo, E., de Neef, P., Waelbroeck, M., Bollen, A., Robberecht, P. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  20. A genomic view of the sea urchin nervous system. Burke, R.D., Angerer, L.M., Elphick, M.R., Humphrey, G.W., Yaguchi, S., Kiyama, T., Liang, S., Mu, X., Agca, C., Klein, W.H., Brandhorst, B.P., Rowe, M., Wilson, K., Churcher, A.M., Taylor, J.S., Chen, N., Murray, G., Wang, D., Mellott, D., Olinski, R., Hallb????k, F., Thorndyke, M.C. Dev. Biol. (2006) [Pubmed]
  21. Molecular cloning and expression of a human secretin receptor. Patel, D.R., Kong, Y., Sreedharan, S.P. Mol. Pharmacol. (1995) [Pubmed]
  22. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. Mahon, M.J., Shimada, M. FEBS Lett. (2005) [Pubmed]
  23. Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding. Du, K., Couvineau, A., Rouyer-Fessard, C., Nicole, P., Laburthe, M. J. Biol. Chem. (2002) [Pubmed]
  24. Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. Hamann, J., Hartmann, E., van Lier, R.A. Genomics (1996) [Pubmed]
  25. Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor. Turner, P.R., Bambino, T., Nissenson, R.A. Mol. Endocrinol. (1996) [Pubmed]
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