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Gene Review

Sctr  -  secretin receptor

Rattus norvegicus

Synonyms: SCT-R, Secretin receptor
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Disease relevance of Sctr


High impact information on Sctr

  • AE-2 gene expression was unaffected by proinflammatory cytokines, whereas CFTR and SR expression was increased [5].
  • Ductal secretion was evaluated by measurement of secretin-induced choleresis, secretin receptor (SR) gene expression, and cyclic adenosine 3',5'-monophosphate (cAMP) levels [6].
  • The secretin receptor expressed in COS cells could specifically bind the iodinated secretin with high and low affinities [7].
  • A complementary DNA encoding the rat secretin receptor was isolated from a CDM8 expression library of NG108-15 cell line [7].
  • However, the amino acid sequence of the secretin receptor has no significant similarity with that of other G protein-coupled receptors [7].

Biological context of Sctr


Anatomical context of Sctr


Associations of Sctr with chemical compounds

  • The secretin receptor is prototypic of the class II family of G protein-coupled receptors, with a long extracellular amino-terminal domain containing six highly conserved Cys residues and one Cys residue (Cys(11)) that is present only in the most closely related family members [16].
  • These data suggest that secretin receptors in the rat brain may be coupled to adenylate cyclase in a stimulatory manner and that secretin-(5-27) may function as a central secretin receptor antagonist [17].
  • Furthermore, treatment with the protein synthesis inhibitor cycloheximide produced a time-dependent increase in secretin receptor responsiveness [3].
  • 2. In whole cell cyclic AMP accumulation studies, activation of PKC either by phorbol 12-myristate 13-acetate (PMA) or by purinoceptor stimulation using uridine 5'-triphosphate (UTP) decreased secretin receptor responsiveness [3].
  • Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes [14].

Physical interactions of Sctr

  • Secretin is a 27-residue peptide hormone with a diffuse pharmacophoric domain that binds to the secretin receptor, a prototypic member of the Class B family of G protein-coupled receptors [18].

Regulatory relationships of Sctr


Other interactions of Sctr


Analytical, diagnostic and therapeutic context of Sctr


  1. Secretin-mediated gene delivery, a specific targeting mechanism with potential for treatment of biliary and pancreatic disease in cystic fibrosis. McKay, T., Reynolds, P., Jezzard, S., Curiel, D., Coutelle, C. Mol. Ther. (2002) [Pubmed]
  2. Peripheral secretin-induced Fos expression in the rat brain is largely vagal dependent. Yang, H., Wang, L., Wu, S.V., Tay, J., Goulet, M., Boismenu, R., Czimmer, J., Wang, Y., Wu, S., Ao, Y., Taché, Y. Neuroscience (2004) [Pubmed]
  3. Second messenger-dependent protein kinases and protein synthesis regulate endogenous secretin receptor responsiveness. Ghadessy, R.S., Kelly, E. Br. J. Pharmacol. (2002) [Pubmed]
  4. Functional characterization and purification of the secretin receptor expressed in baculovirus-infected insect cells. Asmann, Y.W., Dong, M., Miller, L.J. Regul. Pept. (2004) [Pubmed]
  5. Proinflammatory cytokines inhibit secretion in rat bile duct epithelium. Spirlì, C., Nathanson, M.H., Fiorotto, R., Duner, E., Denson, L.A., Sanz, J.M., Di Virgilio, F., Okolicsanyi, L., Casagrande, F., Strazzabosco, M. Gastroenterology (2001) [Pubmed]
  6. Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats. LeSagE, G., Alvaro, D., Benedetti, A., Glaser, S., Marucci, L., Baiocchi, L., Eisel, W., Caligiuri, A., Phinizy, J.L., Rodgers, R., Francis, H., Alpini, G. Gastroenterology (1999) [Pubmed]
  7. Molecular cloning and expression of a cDNA encoding the secretin receptor. Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T., Takahashi, K., Nagata, S. EMBO J. (1991) [Pubmed]
  8. Paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor. Lisenbee, C.S., Dong, M., Miller, L.J. J. Biol. Chem. (2005) [Pubmed]
  9. Agonist-stimulated phosphorylation of the carboxyl-terminal tail of the secretin receptor. Ozcelebi, F., Holtmann, M.H., Rentsch, R.U., Rao, R., Miller, L.J. Mol. Pharmacol. (1995) [Pubmed]
  10. Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor. Dong, M., Wang, Y., Hadac, E.M., Pinon, D.I., Holicky, E., Miller, L.J. J. Biol. Chem. (1999) [Pubmed]
  11. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Alpini, G., Ulrich, C.D., Phillips, J.O., Pham, L.D., Miller, L.J., LaRusso, N.F. Am. J. Physiol. (1994) [Pubmed]
  12. Sudden onset of colitis after ablation of secretin-expressing lymphocytes in transgenic mice. Rindi, G., Civallero, M., Candusso, M.E., Marchetti, A., Klersy, C., Nano, R., Leiter, A.B. Exp. Biol. Med. (Maywood) (2004) [Pubmed]
  13. Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion. Lesage, G., Glaser, S.S., Gubba, S., Robertson, W.E., Phinizy, J.L., Lasater, J., Rodgers, R.E., Alpini, G. Gastroenterology (1996) [Pubmed]
  14. Different actions of secretin and Gly-extended secretin predict secretin receptor subtypes. Solomon, T.E., Varga, G., Zeng, N., Wu, S.V., Walsh, J.H., Reeve, J.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  15. Secretin controls anion secretion in the rat epididymis in an autocrine/paracrine fashion. Chow, B.K., Cheung, K.H., Tsang, E.M., Leung, M.C., Lee, S.M., Wong, P.Y. Biol. Reprod. (2004) [Pubmed]
  16. Structural insights into the amino-terminus of the secretin receptor: I. Status of cysteine and cystine residues. Asmann, Y.W., Dong, M., Ganguli, S., Hadac, E.M., Miller, L.J. Mol. Pharmacol. (2000) [Pubmed]
  17. Secretin stimulates cyclic AMP formation in the rat brain. Fremeau, R.T., Korman, L.Y., Moody, T.W. J. Neurochem. (1986) [Pubmed]
  18. Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor. Dong, M., Li, Z., Zang, M., Pinon, D.I., Lybrand, T.P., Miller, L.J. J. Biol. Chem. (2003) [Pubmed]
  19. Effect of [(CH2NH)4,5]secretin on pancreatic exocrine secretion in guinea pigs and rats. Kim, C.D., Li, P., Lee, K.Y., Coy, D.H., Chey, W.Y. Am. J. Physiol. (1993) [Pubmed]
  20. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Alpini, G., Glaser, S.S., Ueno, Y., Pham, L., Podila, P.V., Caligiuri, A., LeSage, G., LaRusso, N.F. Am. J. Physiol. (1998) [Pubmed]
  21. Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. Caligiuri, A., Glaser, S., Rodgers, R.E., Phinizy, J.L., Robertson, W., Papa, E., Pinzani, M., Alpini, G. Am. J. Physiol. (1998) [Pubmed]
  22. Interaction of amino acid residues at positions 8-15 of secretin with the N-terminal domain of the secretin receptor. Gourlet, P., Vilardaga, J.P., De Neef, P., Vandermeers, A., Waelbroeck, M., Bollen, A., Robberecht, P. Eur. J. Biochem. (1996) [Pubmed]
  23. Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes. Glaser, S.S., Rodgers, R.E., Phinizy, J.L., Robertson, W.E., Lasater, J., Caligiuri, A., Tretjak, Z., LeSage, G.D., Alpini, G. Am. J. Physiol. (1997) [Pubmed]
  24. Interaction among secretagogues on pepsinogen secretion from rat gastric chief cells. Tanaka, T., Tani, S. Biol. Pharm. Bull. (1995) [Pubmed]
  25. Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Unson, C.G., Wu, C.R., Jiang, Y., Yoo, B., Cheung, C., Sakmar, T.P., Merrifield, R.B. Biochemistry (2002) [Pubmed]
  26. Differential spatial approximation between secretin and its receptor residues in active and inactive conformations demonstrated by photoaffinity labeling. Dong, M., Hosohata, K., Pinon, D.I., Muthukumaraswamy, N., Miller, L.J. Mol. Endocrinol. (2006) [Pubmed]
  27. In vitro autoradiographic localization of (125)i-secretin receptor binding sites in rat brain. Nozaki, S., Nakata, R., Mizuma, H., Nishimura, N., Watanabe, Y., Kohashi, R., Watanabe, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  28. Functional and structural characterization of the secretin receptors in rat gastric glands: desensitization and glycoprotein nature. Bawab, W., Chastre, E., Gespach, C. Biosci. Rep. (1991) [Pubmed]
  29. Vagus nerve modulates secretin binding sites in the rat forestomach. Kwon, H.Y., Chang, T.M., Lee, K.Y., Chey, W.Y. Am. J. Physiol. (1999) [Pubmed]
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