Gene Review:
ACKR2 - atypical chemokine receptor 2
Homo sapiens
Synonyms:
Atypical chemokine receptor 2, C-C chemokine receptor D6, CCBP2, CCR10, CCR9, ...
- Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. Qiuping, Z., Qun, L., Chunsong, H., Xiaolian, Z., Baojun, H., Mingzhen, Y., Chengming, L., Jinshen, H., Qingping, G., Kejian, Z., Zhimin, S., Xuejun, Z., Junyan, L., Jinquan, T. Cancer Res. (2003)
- Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. Harasawa, H., Yamada, Y., Hieshima, K., Jin, Z., Nakayama, T., Yoshie, O., Shimizu, K., Hasegawa, H., Hayashi, T., Imaizumi, Y., Ikeda, S., Soda, H., Soda, H., Atogami, S., Takasaki, Y., Tsukasaki, K., Tomonaga, M., Murata, K., Sugahara, K., Tsuruda, K., Kamihira, S. Leuk. Lymphoma (2006)
- Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Annels, N.E., Willemze, A.J., van der Velden, V.H., Faaij, C.M., van Wering, E., Sie-Go, D.M., Egeler, R.M., van Tol, M.J., Révész, T. Blood (2004)
- Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. Nibbs, R.J., Wylie, S.M., Yang, J., Landau, N.R., Graham, G.J. J. Biol. Chem. (1997)
- Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Liu, C., Saito, F., Liu, Z., Lei, Y., Uehara, S., Love, P., Lipp, M., Kondo, S., Manley, N., Takahama, Y. Blood (2006)
- Selective thymus settling regulated by cytokine and chemokine receptors. Schwarz, B.A., Sambandam, A., Maillard, I., Harman, B.C., Love, P.E., Bhandoola, A. J. Immunol. (2007)
- Evidence for NK cell subsets based on chemokine receptor expression. Berahovich, R.D., Lai, N.L., Wei, Z., Lanier, L.L., Schall, T.J. J. Immunol. (2006)
- Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines. Locati, M., Torre, Y.M., Galliera, E., Bonecchi, R., Bodduluri, H., Vago, G., Vecchi, A., Mantovani, A. Cytokine Growth Factor Rev. (2005)
- The binding between p67 and eukaryotic initiation factor 2 plays important roles in the protection of eIF2alpha from phosphorylation by kinases. Datta, B., Datta, R., Ghosh, A., Majumdar, A. Arch. Biochem. Biophys. (2006)
- beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. Galliera, E., Jala, V.R., Trent, J.O., Bonecchi, R., Signorelli, P., Lefkowitz, R.J., Mantovani, A., Locati, M., Haribabu, B. J. Biol. Chem. (2004)
- Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. Fra, A.M., Locati, M., Otero, K., Sironi, M., Signorelli, P., Massardi, M.L., Gobbi, M., Vecchi, A., Sozzani, S., Mantovani, A. J. Immunol. (2003)
- The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. Neil, S.J., Aasa-Chapman, M.M., Clapham, P.R., Nibbs, R.J., McKnight, A., Weiss, R.A. J. Virol. (2005)
- Expression of CCR9 in HTLV-1(+) T cells and ATL cells expressing Tax. Nagakubo, D., Jin, Z., Hieshima, K., Nakayama, T., Shirakawa, A.K., Tanaka, Y., Hasegawa, H., Hayashi, T., Tsukasaki, K., Yamada, Y., Yoshie, O. Int. J. Cancer (2007)
- The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Nibbs, R.J., Kriehuber, E., Ponath, P.D., Parent, D., Qin, S., Campbell, J.D., Henderson, A., Kerjaschki, D., Maurer, D., Graham, G.J., Rot, A. Am. J. Pathol. (2001)
- Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor. Bonecchi, R., Locati, M., Galliera, E., Vulcano, M., Sironi, M., Fra, A.M., Gobbi, M., Vecchi, A., Sozzani, S., Haribabu, B., Van Damme, J., Mantovani, A. J. Immunol. (2004)
- Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy. Kivisäkk, P., Tucky, B., Wei, T., Campbell, J.J., Ransohoff, R.M. BMC Immunol. (2006)
- Role of the CC chemokine receptor 9/TECK interaction in apoptosis. Youn, B.S., Yu, K.Y., Oh, J., Lee, J., Lee, T.H., Broxmeyer, H.E. Apoptosis (2002)
- Negative regulation of the protection of eIF2alpha phosphorylation activity by a unique acidic domain present at the N-terminus of p67. Datta, R., Tammali, R., Datta, B. Exp. Cell Res. (2003)
- Circulating clonal CLA(+) and CD4(+) T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7. Sokolowska-Wojdylo, M., Wenzel, J., Gaffal, E., Lenz, J., Speuser, P., Erdmann, S., Abuzahra, F., Bowman, E., Roszkiewicz, J., Bieber, T., Tüting, T. Br. J. Dermatol. (2005)
- The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. Weber, M., Blair, E., Simpson, C.V., O'Hara, M., Blackburn, P.E., Rot, A., Graham, G.J., Nibbs, R.J. Mol. Biol. Cell (2004)
- Features and functions of gamma delta T lymphocytes: focus on chemokines and their receptors. Kabelitz, D., Wesch, D. Crit. Rev. Immunol. (2003)
- Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape. Simonetti, O., Goteri, G., Lucarini, G., Filosa, A., Pieramici, T., Rubini, C., Biagini, G., Offidani, A. Eur. J. Cancer (2006)