Gene Review:
SIM2 - single-minded family bHLH transcription...
Homo sapiens
Synonyms:
BHLHE15, Class E basic helix-loop-helix protein 15, HMC13F06, HMC29C01, MGC119447, ...
- Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. Chrast, R., Scott, H.S., Chen, H., Kudoh, J., Rossier, C., Minoshima, S., Wang, Y., Shimizu, N., Antonarakis, S.E. Genome Res. (1997)
- Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. Woods, S.L., Whitelaw, M.L. J. Biol. Chem. (2002)
- Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. Muenke, M., Bone, L.J., Mitchell, H.F., Hart, I., Walton, K., Hall-Johnson, K., Ippel, E.F., Dietz-Band, J., Kvaløy, K., Fan, C.M. Am. J. Hum. Genet. (1995)
- Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target. DeYoung, M.P., Tress, M., Narayanan, R. Cancer Lett. (2003)
- Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. DeYoung, M.P., Tress, M., Narayanan, R. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Molecular mechanisms of human single-minded 2 (SIM2) gene expression: identification of a promoter site in the SIM2 genomic sequence. Yamaki, A., Tochigi, J., Kudoh, J., Minoshima, S., Shimizu, N., Shimizu, Y. Gene (2001)
- Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in Down syndrome. Rachidi, M., Lopes, C., Charron, G., Delezoide, A.L., Paly, E., Bloch, B., Delabar, J.M. Int. J. Dev. Neurosci. (2005)
- Identifying patients at high and low risk of cognitive decline using Rey Auditory Verbal Learning Test among middle-aged memory clinic outpatients. Andersson, C., Lindau, M., Almkvist, O., Engfeldt, P., Johansson, S.E., Eriksdotter Jonhagen, M. Dementia and geriatric cognitive disorders. (2006)
- Effect of Fv-1 gene product on synthesis of N-tropic and B-tropic murine leukemia viral RNA. Jolicoeur, P., Baltimore, D. Cell (1976)
- PAS is a dimerization domain common to Drosophila period and several transcription factors. Huang, Z.J., Edery, I., Rosbash, M. Nature (1993)
- Mining genome databases for therapeutic gold: SIM2 is a novel target for treatment of solid tumors. Ratan, R.R. Trends Pharmacol. Sci. (2003)
- Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Kubota, H., Avarbock, M.R., Brinster, R.L. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases. Okui, M., Yamaki, A., Takayanagi, A., Kudoh, J., Shimizu, N., Shimizu, Y. Exp. Cell Res. (2005)
- A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2. Yamaki, A., Kudoh, J., Shimizu, N., Shimizu, Y. Biochem. Biophys. Res. Commun. (2004)
- Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. Probst, M.R., Fan, C.M., Tessier-Lavigne, M., Hankinson, O. J. Biol. Chem. (1997)
- The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. Yamaki, A., Noda, S., Kudoh, J., Shindoh, N., Maeda, H., Minoshima, S., Kawasaki, K., Shimizu, Y., Shimizu, N. Genomics (1996)
- Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry reveal a remarkable degree of structural damage in the DNA of wild fish exposed to toxic chemicals. Malins, D.C., Gunselman, S.J. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Comparison of microemulsion and conventional formulations of cyclosporine A in preventing acute rejection in de novo kidney transplant patients. The U.K. Neoral Renal Study Group. Pollard, S.G., Lear, P.A., Ready, A.R., Moore, R.H., Johnson, R.W. Transplantation (1999)
- Overexpression of transcription factor BACH1 in fetal Down syndrome brain. Ferrando-Miguel, R., Cheon, M.S., Yang, J.W., Lubec, G. J. Neural Transm. Suppl. (2003)
- The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. Hogenesch, J.B., Gu, Y.Z., Moran, S.M., Shimomura, K., Radcliffe, L.A., Takahashi, J.S., Bradfield, C.A. J. Neurosci. (2000)
- A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region. Osoegawa, K., Okano, S., Kato, Y., Nishimura, Y., Soeda, E. DNA Res. (1996)
- Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Ansari-Lari, M.A., Oeltjen, J.C., Schwartz, S., Zhang, Z., Muzny, D.M., Lu, J., Gorrell, J.H., Chinault, A.C., Belmont, J.W., Miller, W., Gibbs, R.A. Genome Res. (1998)
- Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. Wang, J., Xiong, S., Xie, C., Markesbery, W.R., Lovell, M.A. J. Neurochem. (2005)