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Gene Review

BACH1  -  BTB and CNC homology 1, basic leucine...

Homo sapiens

Synonyms: BACH-1, BTB and CNC homolog 1, BTBD24, HA2303, Transcription regulator protein BACH1
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Disease relevance of BACH1


Psychiatry related information on BACH1


High impact information on BACH1


Chemical compound and disease context of BACH1


Biological context of BACH1


Anatomical context of BACH1


Associations of BACH1 with chemical compounds


Regulatory relationships of BACH1

  • More specifically, BACH1 suppresses expression of HO1 [1].
  • Diamide showed restricted Nrf2 nuclear translocation and ARE-driven reporter activity but reversed the ARE transcriptional activity suppressed by ectopically expressed Bach1 [15].

Other interactions of BACH1


Analytical, diagnostic and therapeutic context of BACH1

  • Brain homogenates were subject to immunoblotting using goat-anti-BACH1, rabbit anti-heme oxygenase 1 (HO1), rabbit anti-ERG, rabbit anti-RUNX1 and goat anti-SIM2 l [1].
  • Several hydrogen bonds and salt bridges that stabilize the BRCA1-BACH1 complex are missing in the BRCA1-CtIP interaction, offering a structural basis for the approximately 5-fold lower affinity of BRCA1 for CtIP compared to that of BACH1, as determined by isothermal titration calorimetry [17].
  • The association of nocturia with cardiac disease, diabetes, body mass index, age and diuretic use: results from the BACH survey [20].
  • Cohort and case-control studies were performed on all adult and pediatric AES patients admitted to the Neurology Service of Bach Mai Hospital between June 5 and August 3, 1995 [21].
  • Bach recently surveyed 273 MDA clinic directors and co-directors from 167 clinics, to evaluate their current use of mechanical ventilation [22].


  1. Overexpression of transcription factor BACH1 in fetal Down syndrome brain. Ferrando-Miguel, R., Cheon, M.S., Yang, J.W., Lubec, G. J. Neural Transm. Suppl. (2003) [Pubmed]
  2. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P.R., Cantor, S.B. Cancer Cell (2005) [Pubmed]
  3. Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. Kitamuro, T., Takahashi, K., Ogawa, K., Udono-Fujimori, R., Takeda, K., Furuyama, K., Nakayama, M., Sun, J., Fujita, H., Hida, W., Hattori, T., Shirato, K., Igarashi, K., Shibahara, S. J. Biol. Chem. (2003) [Pubmed]
  4. HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. Ghaziani, T., Shan, Y., Lambrecht, R.W., Donohue, S.E., Pietschmann, T., Bartenschlager, R., Bonkovsky, H.L. J. Hepatol. (2006) [Pubmed]
  5. BACH1 517C-->T transition impairs protein translocation to nucleus: a role in breast cancer susceptibility? Lei, H., Vorechovsky, I. Int. J. Cancer (2003) [Pubmed]
  6. Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease. Shim, K.S., Ferrando-Miguel, R., Lubec, G. J. Neural Transm. Suppl. (2003) [Pubmed]
  7. Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Bourquin, J.P., Subramanian, A., Langebrake, C., Reinhardt, D., Bernard, O., Ballerini, P., Baruchel, A., Cavé, H., Dastugue, N., Hasle, H., Kaspers, G.L., Lessard, M., Michaux, L., Vyas, P., van Wering, E., Zwaan, C.M., Golub, T.R., Orkin, S.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. Gupta, R., Sharma, S., Sommers, J.A., Jin, Z., Cantor, S.B., Brosh, R.M. J. Biol. Chem. (2005) [Pubmed]
  9. Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. Shan, Y., Lambrecht, R.W., Ghaziani, T., Donohue, S.E., Bonkovsky, H.L. J. Biol. Chem. (2004) [Pubmed]
  10. Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. Tahara, T., Sun, J., Igarashi, K., Taketani, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. Blouin, J.L., Duriaux Saïl, G., Guipponi, M., Rossier, C., Pappasavas, M.P., Antonarakis, S.E. Hum. Genet. (1998) [Pubmed]
  12. Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells. Udono-Fujimori, R., Takahashi, K., Takeda, K., Furuyama, K., Kaneko, K., Takahashi, S., Tamai, M., Shibahara, S. Eur. J. Biochem. (2004) [Pubmed]
  13. beta-Carotene and Cigarette Smoke Condensate Regulate Heme Oxygenase-1 and Its Repressor Factor Bach1: Relationship with Cell Growth. Palozza, P., Serini, S., Currò, D., Calviello, G., Igarashi, K., Mancuso, C. Antioxid. Redox Signal. (2006) [Pubmed]
  14. Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. Gorlatov, S., Medved, L. Biochemistry (2002) [Pubmed]
  15. Redox regulation of the transcriptional repressor Bach1. Ishikawa, M., Numazawa, S., Yoshida, T. Free Radic. Biol. Med. (2005) [Pubmed]
  16. Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Ryter, S.W., Choi, A.M. Antioxid. Redox Signal. (2005) [Pubmed]
  17. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Varma, A.K., Brown, R.S., Birrane, G., Ladias, J.A. Biochemistry (2005) [Pubmed]
  18. Novel potential ALL low-risk markers revealed by gene expression profiling with new high-throughput SSH-CCS-PCR. Qiu, J., Gunaratne, P., Peterson, L.E., Khurana, D., Walsham, N., Loulseged, H., Karni, R.J., Roussel, E., Gibbs, R.A., Margolin, J.F., Gingras, M.C. Leukemia (2003) [Pubmed]
  19. BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. Reichard, J.F., Sartor, M.A., Puga, A. J. Biol. Chem. (2008) [Pubmed]
  20. The association of nocturia with cardiac disease, diabetes, body mass index, age and diuretic use: results from the BACH survey. Fitzgerald, M.P., Litman, H.J., Link, C.L., McKinlay, J.B. J. Urol. (2007) [Pubmed]
  21. Japanese encephalitis among hospitalized pediatric and adult patients with acute encephalitis syndrome in Hanoi, Vietnam 1995. Lowry, P.W., Truong, D.H., Hinh, L.D., Ladinsky, J.L., Karabatsos, N., Cropp, C.B., Martin, D., Gubler, D.J. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
  22. Noninvasive ventilation in neuromuscular disease. Bonekat, H.W. Critical care clinics. (1998) [Pubmed]
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