Gene Review:
Cbs - cystathionine beta-synthase
Mus musculus
Synonyms:
AI047524, AI303044, Beta-thionase, Cystathionine beta-synthase, HIP4, ...
- Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Wang, H., Jiang, X., Yang, F., Gaubatz, J.W., Ma, L., Magera, M.J., Yang, X., Berger, P.B., Durante, W., Pownall, H.J., Schafer, A.I. Blood (2003)
- The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia. Robert, K., Santiard-Baron, D., Chassé, J.F., Paly, E., Aupetit, J., Kamoun, P., London, J., Janel, N. J. Neurochem. (2004)
- Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Pacheco-Quinto, J., Rodriguez de Turco, E.B., DeRosa, S., Howard, A., Cruz-Sanchez, F., Sambamurti, K., Refolo, L., Petanceska, S., Pappolla, M.A. Neurobiol. Dis. (2006)
- Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Wang, L., Chen, X., Tang, B., Hua, X., Klein-Szanto, A., Kruger, W.D. Hum. Mol. Genet. (2005)
- Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Robert, K., Nehmé, J., Bourdon, E., Pivert, G., Friguet, B., Delcayre, C., Delabar, J.M., Janel, N. Gastroenterology (2005)
- Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. Eberhardt, R.T., Forgione, M.A., Cap, A., Leopold, J.A., Rudd, M.A., Trolliet, M., Heydrick, S., Stark, R., Klings, E.S., Moldovan, N.I., Yaghoubi, M., Goldschmidt-Clermont, P.J., Farber, H.W., Cohen, R., Loscalzo, J. J. Clin. Invest. (2000)
- Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. Namekata, K., Enokido, Y., Ishii, I., Nagai, Y., Harada, T., Kimura, H. J. Biol. Chem. (2004)
- Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Lentz, S.R., Erger, R.A., Dayal, S., Maeda, N., Malinow, M.R., Heistad, D.D., Faraci, F.M. Am. J. Physiol. Heart Circ. Physiol. (2000)
- Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Dayal, S., Wilson, K.M., Leo, L., Arning, E., Bottiglieri, T., Lentz, S.R. Blood (2006)
- The gene for cystathionine beta-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17. Münke, M., Kraus, J.P., Ohura, T., Francke, U. Am. J. Hum. Genet. (1988)
- The alpha-A-crystallin and cystathionine beta-synthase genes are physically very closely linked in proximal mouse chromosome 17. Stubbs, L., Kraus, J., Lehrach, H. Genomics (1990)
- Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Vitvitsky, V., Dayal, S., Stabler, S., Zhou, Y., Wang, H., Lentz, S.R., Banerjee, R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain. Robert, K., Vialard, F., Thiery, E., Toyama, K., Sinet, P.M., Janel, N., London, J. J. Histochem. Cytochem. (2003)
- Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Watanabe, M., Osada, J., Aratani, Y., Kluckman, K., Reddick, R., Malinow, M.R., Maeda, N. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia. Robert, K., Maurin, N., Ledru, A., Delabar, J., Janel, N. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2004)
- Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. Enokido, Y., Suzuki, E., Iwasawa, K., Namekata, K., Okazawa, H., Kimura, H. FASEB J. (2005)
- Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Oh, G.S., Pae, H.O., Lee, B.S., Kim, B.N., Kim, J.M., Kim, H.R., Jeon, S.B., Jeon, W.K., Chae, H.J., Chung, H.T. Free Radic. Biol. Med. (2006)
- Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia. Sood, H.S., Hunt, M.J., Tyagi, S.C. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Schwahn, B.C., Wendel, U., Lussier-Cacan, S., Mar, M.H., Zeisel, S.H., Leclerc, D., Castro, C., Garrow, T.A., Rozen, R. Metab. Clin. Exp. (2004)
- Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Dayal, S., Arning, E., Bottiglieri, T., Böger, R.H., Sigmund, C.D., Faraci, F.M., Lentz, S.R. Stroke (2004)
- Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Zhang, H., Zhi, L., Moore, P.K., Bhatia, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Altered gene expression in liver from a murine model of hyperhomocysteinemia. Robert, K., Chassé, J.F., Santiard-Baron, D., Vayssettes, C., Chabli, A., Aupetit, J., Maeda, N., Kamoun, P., London, J., Janel, N. J. Biol. Chem. (2003)
- Plasma albumin cysteinylation is regulated by cystathionine beta-synthase. Bar-Or, D., Curtis, C.G., Sullivan, A., Rael, L.T., Thomas, G.W., Craun, M., Bar-Or, R., Maclean, K.N., Kraus, J.P. Biochem. Biophys. Res. Commun. (2004)
- Correlation between induction of duodenal tumor by hydrogen peroxide and catalase activity in mice. Ito, A., Watanabe, H., Naito, M., Naito, Y., Kawashima, K. Gann = Gan. (1984)
- Effect of hyperhomocysteinemia on protein C activation and activity. Lentz, S.R., Piegors, D.J., Fernández, J.A., Erger, R.A., Arning, E., Malinow, M.R., Griffin, J.H., Bottiglieri, T., Haynes, W.G., Heistad, D.D. Blood (2002)