The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

PCNA  -  proliferating cell nuclear antigen

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PCNA


High impact information on PCNA


Biological context of PCNA


Anatomical context of PCNA

  • Scattered cells labelled with anti-BrdUrd or anti-PCNA antibodies were detected within the ES whereas labelled cells were not found in either the cochlea or the vestibule [13].
  • These findings were associated with increased frequency of hepatocytes with apoptotic bodies and positivity for proliferating cell nuclear antigen (PCNA) in livers from ethanol-fed minipigs [14].
  • PCNA staining of 1-week vein grafts confirmed in vivo anti-proliferative effects of paclitaxel (21+/-2 vs. 36+/-3%, n=5, p<0.01) and rapamycin (32+/-1 vs. 57+/-6%, n=6, p<0.005); neither agent stimulated loss of endothelium at these concentrations [15].
  • PCNA staining was prominent within tubular primordia and was higher in testes from Yorkshire than from Meishan fetuses on all days examined [16].
  • Abundance of IGF-I and PCNA mRNAs was increased by E and inhibited by coaddition of either T or N in Day 10 pregnant pig endometrium [17].

Associations of PCNA with chemical compounds

  • PCNA labeling increased opposite to the injury site in both control and capsaicin animals over the first 72 h [18].
  • To evaluate a role for AR in uterine gene regulation, the levels of mRNAs for insulin-like growth factor-I (IGF-I), proliferative cell nuclear antigen (PCNA), and AR itself were assessed in uterine endometrial explant cultures treated with estradiol-17beta (E), testosterone (T), and 19-nortestosterone (N) [17].
  • In contrast, PCNA mRNA abundance was suppressed by all steroid treatments in these explants [17].
  • In the presence of deferoxamine, [3H] methyl-thymidine incorporation, expression of nuclear proteins (p34cdc2 and PCNA) and H1 kinase activity were drastically reduced [19].
  • RESULTS: at 24 h, PCNA-positive nuclei revealed 33+/-14 and 12+/-3 proliferating cells/mm2 at placebo and molsidomine PTA-LDD sites, respectively (p<0.001) [20].

Other interactions of PCNA


Analytical, diagnostic and therapeutic context of PCNA


  1. The effect of Erigeron breviscapus on proliferation of pulmonary artery smooth muscle cells in hypoxic porcines. Ding, Y., Xu, Y., Zhang, Z. J. Tongji Med. Univ. (2001) [Pubmed]
  2. Effects of Helicobacter pylori infection on porcine gastric epithelial cell proliferation. Song, H., Sun, G.H., Huang, X.R., Lai, R.Q., Luo, Z.Q., Zhang, W., Tian, Y., Deng, Y.J. Di Yi Jun Yi Da Xue Xue Bao (2002) [Pubmed]
  3. Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model. Suzuki, T., Kopia, G., Hayashi , S., Bailey, L.R., Llanos, G., Wilensky, R., Klugherz, B.D., Papandreou, G., Narayan, P., Leon, M.B., Yeung, A.C., Tio, F., Tsao, P.S., Falotico, R., Carter, A.J. Circulation (2001) [Pubmed]
  4. Apoptosis and cell proliferation after porcine coronary angioplasty. Malik, N., Francis, S.E., Holt, C.M., Gunn, J., Thomas, G.L., Shepherd, L., Chamberlain, J., Newman, C.M., Cumberland, D.C., Crossman, D.C. Circulation (1998) [Pubmed]
  5. Local delivery of ethanol inhibits intimal hyperplasia in pig coronary arteries after balloon injury. Liu, M.W., Anderson, P.G., Luo, J.F., Roubin, G.S. Circulation (1997) [Pubmed]
  6. Inhibition of neointimal proliferation with low-dose irradiation from a beta-particle-emitting stent. Laird, J.R., Carter, A.J., Kufs, W.M., Hoopes, T.G., Farb, A., Nott, S.H., Fischell, R.E., Fischell, D.R., Virmani, R., Fischell, T.A. Circulation (1996) [Pubmed]
  7. Adventitial remodeling after coronary arterial injury. Shi, Y., Pieniek, M., Fard, A., O'Brien, J., Mannion, J.D., Zalewski, A. Circulation (1996) [Pubmed]
  8. Morphologic characteristics of lesion formation and time course of smooth muscle cell proliferation in a porcine proliferative restenosis model. Carter, A.J., Laird, J.R., Farb, A., Kufs, W., Wortham, D.C., Virmani, R. J. Am. Coll. Cardiol. (1994) [Pubmed]
  9. PGE(2) stimulates vascular smooth muscle cell proliferation via the EP2 receptor. Yau, L., Zahradka, P. Mol. Cell. Endocrinol. (2003) [Pubmed]
  10. Effect of growth factors on proliferation, apoptosis and protein kinase A expression in cultured porcine cumulus oophorus cells. Sirotkin, A.V., Dukesová, J., Pivko, J., Makarevich, A.V., Kúbek, A. Reprod. Nutr. Dev. (2002) [Pubmed]
  11. The use of proliferating cell nuclear antigen immunohistochemistry with a unique functional marker to detect postnatal neurogenesis in paraffin-embedded sections of the mature pig brain. Rankin, S.L., Partlow, G.D., McCurdy, R.D., Giles, E.D., Fisher, K.R. Brain Res. Brain Res. Protoc. (2004) [Pubmed]
  12. Effects of energy and purines in the diet on proliferation, differentiation, and apoptosis in the small intestine of the pig. Raab, S., Leiser, R., Kemmer, H., Claus, R. Metab. Clin. Exp. (1998) [Pubmed]
  13. S-phase cells in the guinea pig endolymphatic sac. Takahashi, M., Hokunan, K., Unno, T. Acta Otolaryngol. (1994) [Pubmed]
  14. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Halsted, C.H., Villanueva, J., Chandler, C.J., Stabler, S.P., Allen, R.H., Muskhelishvili, L., James, S.J., Poirier, L. Hepatology (1996) [Pubmed]
  15. Short- and long-term effects of cytochalasin D, paclitaxel and rapamycin on wall thickening in experimental porcine vein grafts. Murphy, G.J., Johnson, T.W., Chamberlain, M.H., Rizvi, S.I., Wyatt, M., George, S.J., Angelini, G.D., Karsch, K.R., Oberhoff, M., Newby, A.C. Cardiovasc. Res. (2007) [Pubmed]
  16. Development and differentiation of the interstitial and tubular compartments of fetal porcine testes. Kaminski, M.A., Corbin, C.J., Conley, A.J. Biol. Reprod. (1999) [Pubmed]
  17. Uterine androgen receptors: roles in estrogen-mediated gene expressionand DNA synthesis. Kowalski, A.A., Vale-Cruz, D.S., Simmen, F.A., Simmen, R.C. Biol. Reprod. (2004) [Pubmed]
  18. Proliferation and repair of guinea pig tracheal epithelium after neuropeptide depletion and injury in vivo. Kim, J.S., McKinnis, V.S., Adams, K., White, S.R. Am. J. Physiol. (1997) [Pubmed]
  19. Deferoxamine arrests in vitro the proliferation of porcine hepatocyte in G1 phase of the cell cycle. Chenoufi, N., Baffet, G., Drénou, B., Cariou, S., Desille, M., Clément, B., Brissot, P., Lescoat, G., Loréal, O. Liver (1998) [Pubmed]
  20. Local delivery of NO-donor molsidomine post-PTA improves haemodynamics, wall mechanics and histomorphometry in atherosclerotic porcine SFA. Rolland, P.H., Bartoli, J.M., Piquet, P., Mekkaoui, C., Nott, S.H., Moulin, G., Amabile, P., Mesana, T. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2002) [Pubmed]
  21. The effect of basic fibroblast growth factor on the regeneration of guinea pig olfactory epithelium. Nakamura, H., Higuchi, Y., Kondoh, H., Obata, M., Takahashi, S. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. (2002) [Pubmed]
  22. Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis. Manikkam, M., Li, Y., Mitchell, B.M., Mason, D.E., Freeman, L.C. Biol. Reprod. (2002) [Pubmed]
  23. Effects of DDPH on HECCM-induced proliferation and immunophenotypes of the pulmonary vascular pericytes. Yuan, Y., Che, D., Xiong, M. J. Tongji Med. Univ. (2001) [Pubmed]
  24. The role of oxytocin, protein kinase A, and ERK-related MAP-kinase in the control of porcine ovarian follicle functions. Makarevich, A.V., Sirotkin, A.V., Franek, J., Kwon, H.B., Bulla, J. Exp. Clin. Endocrinol. Diabetes (2004) [Pubmed]
  25. Proliferation of masseter myocytes after distraction osteogenesis of the porcine mandible. Castaño, F.J., Troulis, M.J., Glowacki, J., Kaban, L.B., Yates, K.E. J. Oral Maxillofac. Surg. (2001) [Pubmed]
WikiGenes - Universities