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Gene Review

CASP3  -  caspase 3, apoptosis-related cysteine...

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Disease relevance of CASP3


High impact information on CASP3


Chemical compound and disease context of CASP3


Biological context of CASP3

  • The porcine caspase-3 cDNA isolated in this study will be useful for the study of apoptotic cell death in pigs and will lead to the discovery of therapeutic uses of caspases and their inhibitors in the prevention of viral and bacterial diseases and tissue injury associated with xenotransplantation and allotransplantation [11].
  • Changes in caspase-3 activation and c-Jun phosphorylation were most marked in the proximal region of the jejunum [1].
  • The open reading frame (ORF) of porcine caspase-3 cDNA was 834 base pairs (bp) in length and encoded 277 amino acids [11].
  • Cellular proliferation and apoptosis were measured [apoptosis by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP) nick end-labeling (TUNEL) assay or by caspase-3 activity] [12].
  • Brain cell injury was assessed with caspase-3 activity, histology, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end (TUNEL)-labeling [13].

Anatomical context of CASP3


Associations of CASP3 with chemical compounds

  • PDE4A11 differs from PDE4A4 in sensitivity to cleavage by caspase-3, interaction with LYN SH3 domain, redistribution upon long-term rolipram challenge, and sensitivity to certain PDE4 inhibitors [15].
  • In addition, beraprost sodium reversed the ioversol-induced increase in bax mRNA with a concomitant decrease in bcl-2 mRNA and subsequent activation of caspase-3 and -9, thereby resulting in the inhibition of the nuclear damage [16].
  • HO-1 overexpressing cells were markedly resistant to apoptosis induced by TNFalpha/cycloheximide or staurosporine as assessed by the caspase-3 activity assay [17].
  • Finally, bezafibrate prevented cisplatin-induced release of cytochrome c from the mitochondria to the cytosol, and the cleavage of procaspase-3 to active caspase-3 [18].
  • UVB also increased activated caspase-3, in a manner suppressible by mono-dansyl cadaverine [19].

Regulatory relationships of CASP3


Other interactions of CASP3

  • The effects of hypoxia on the neonatal brain were characterized through a time-course analysis of levels of various proteins such as heat shock proteins (HSP27, 70, and 90), hypoxia inducible factor-1alpha (HIF-1alpha), neuronal nitric oxide synthase (nNOS), hemeoxygenase-2 (HO-2), and caspase-3 [5].
  • The permeable exogenous C(2)-ceramide reproduces IL-1beta effects on: (i) inhibition of adenylyl cyclase activity, (ii) down-regulation of ERK1/2 phosphorylation, (iii) activation of caspase-3, and (iv) apoptosis in pig thyroid cells [24].
  • Only at the highest dose (200 ng/ml) when leptin was added with IGF-I did P4 secretion decrease with no effect on the caspase-3 activity [25].
  • Instead, they produced increasing amounts of MMP-9, MMP-13, COX-2, activated caspase-3 and underwent apoptosis [26].
  • RESULTS: Our results indicated that linoleic acid and TNF-alpha independently, but more markedly in concert, up-regulated caspase-3 activity and induced annexin V binding and DNA fragmentation [27].

Analytical, diagnostic and therapeutic context of CASP3


  1. Salmonella typhimurium infection in the porcine intestine: evidence for caspase-3-dependent and -independent programmed cell death. Schauser, K., Olsen, J.E., Larsson, L.I. Histochem. Cell Biol. (2005) [Pubmed]
  2. Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. Wang, J., Ladrech, S., Pujol, R., Brabet, P., Van De Water, T.R., Puel, J.L. Cancer Res. (2004) [Pubmed]
  3. African swine fever virus IAP-like protein induces the activation of nuclear factor kappa B. Rodríguez, C.I., Nogal, M.L., Carrascosa, A.L., Salas, M.L., Fresno, M., Revilla, Y. J. Virol. (2002) [Pubmed]
  4. Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection. Perfettini, J.L., Reed, J.C., Israël, N., Martinou, J.C., Dautry-Varsat, A., Ojcius, D.M. Infect. Immun. (2002) [Pubmed]
  5. Effects of hypoxia on stress proteins in the piglet brain at birth. Chiral, M., Grongnet, J.F., Plumier, J.C., David, J.C. Pediatr. Res. (2004) [Pubmed]
  6. Caspase inhibition reduces apoptotic death of cryopreserved porcine hepatocytes. Yagi, T., Hardin, J.A., Valenzuela, Y.M., Miyoshi, H., Gores, G.J., Nyberg, S.L. Hepatology (2001) [Pubmed]
  7. Down-regulation of osteoclast differentiation by daidzein via caspase 3. Rassi, C.M., Lieberherr, M., Chaumaz, G., Pointillart, A., Cournot, G. J. Bone Miner. Res. (2002) [Pubmed]
  8. Exogenous nitric oxide inhibits apoptosis in guinea pig gastric mucous cells. Potter, C.L., Hanson, P.J. Gut (2000) [Pubmed]
  9. The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells. Zhan, Y., van de Water, B., Wang, Y., Stevens, J.L. Oncogene (1999) [Pubmed]
  10. Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia. Peeters-Scholte, C., Koster, J., Veldhuis, W., van den Tweel, E., Zhu, C., Kops, N., Blomgren, K., Bär, D., van Buul-Offers, S., Hagberg, H., Nicolay, K., van Bel, F., Groenendaal, F. Stroke (2002) [Pubmed]
  11. Porcine caspase-3: its cloning and activity during apoptosis of PK15 cells induced by porcine Fas ligand. Muneta, Y., Shimoji, Y., Mori, Y. J. Interferon Cytokine Res. (2001) [Pubmed]
  12. Cytoprotection by darbepoetin/epoetin alfa in pig tubular and mouse mesangial cells. Fishbane, S., Ragolia, L., Palaia, T., Johnson, B., Elzein, H., Maesaka, J.K. Kidney Int. (2004) [Pubmed]
  13. Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia. Peeters-Scholte, C., Braun, K., Koster, J., Kops, N., Blomgren, K., Buonocore, G., van Buul-Offers, S., Hagberg, H., Nicolay, K., van Bel, F., Groenendaal, F. Pediatr. Res. (2003) [Pubmed]
  14. Increased neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet brainstem. Machaalani, R., Waters, K.A. Brain Res. (2003) [Pubmed]
  15. Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. Wallace, D.A., Johnston, L.A., Huston, E., MacMaster, D., Houslay, T.M., Cheung, Y.F., Campbell, L., Millen, J.E., Smith, R.A., Gall, I., Knowles, R.G., Sullivan, M., Houslay, M.D. Mol. Pharmacol. (2005) [Pubmed]
  16. A prostacyclin analog beraprost sodium attenuates radiocontrast media-induced LLC-PK1 cells injury. Yano, T., Itoh, Y., Kubota, T., Sendo, T., Oishi, R. Kidney Int. (2004) [Pubmed]
  17. Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis. Inguaggiato, P., Gonzalez-Michaca, L., Croatt, A.J., Haggard, J.J., Alam, J., Nath, K.A. Kidney Int. (2001) [Pubmed]
  18. Fibrate prevents cisplatin-induced proximal tubule cell death. Nagothu, K.K., Bhatt, R., Kaushal, G.P., Portilla, D. Kidney Int. (2005) [Pubmed]
  19. Transglutaminase Participates in UVB-Induced Cell Death Pathways in Human Corneal Epithelial Cells. Tong, L., Chen, Z., De Paiva, C.S., Beuerman, R., Li, D.Q., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  20. Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1. Teshima, S., Kutsumi, H., Kawahara, T., Kishi, K., Rokutan, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  21. Cellular glutathione status modulates polychlorinated biphenyl-induced stress response and apoptosis in vascular endothelial cells. Slim, R., Toborek, M., Robertson, L.W., Lehmler, H.J., Hennig, B. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  22. Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture. Tsutsumi, S., Tomisato, W., Takano, T., Rokutan, K., Tsuchiya, T., Mizushima, T. Biochim. Biophys. Acta (2002) [Pubmed]
  23. Thyroid hormone synergizes with follicle stimulating hormone to inhibit apoptosis in porcine granulosa cells selectively from small follicles. Asahara, S., Sato, A., Aljonaid, A.A., Maruo, T. The Kobe journal of medical sciences. (2003) [Pubmed]
  24. Interleukin-1beta-induced apoptosis through adenylyl cyclase and ERK1/2 inhibition in primary cultured thyroid cells. El Btaouri, H., Rath, G., Morjani, H., Schneider, C., Petitfrere, E., Antonicelli, F., Martiny, L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  25. In vitro effect of leptin on growth hormone (GH)- and insulin-like growth factor-I (IGF-I)-stimulated progesterone secretion and apoptosis in developing and mature corpora lutea of pig ovaries. Gregoraszczuk, E.Ł., Ptak, A. J. Reprod. Dev. (2005) [Pubmed]
  26. Development and phenotypic characterization of a high density in vitro model of auricular chondrocytes with applications in reconstructive plastic surgery. Haisch, A., Marzahn, U., Mobasheri, A., Schulze-Tanzil, G., Shakibaei, M. Histol. Histopathol. (2006) [Pubmed]
  27. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. Meerarani, P., Ramadass, P., Toborek, M., Bauer, H.C., Bauer, H., Hennig, B. Am. J. Clin. Nutr. (2000) [Pubmed]
  28. Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells. Terada, Y., Inoshita, S., Hanada, S., Shimamura, H., Kuwahara, M., Ogawa, W., Kasuga, M., Sasaki, S., Marumo, F. Kidney Int. (2001) [Pubmed]
  29. Protection of porcine oocytes against apoptotic cell death caused by oxidative stress during In vitro maturation: role of cumulus cells. Tatemoto, H., Sakurai, N., Muto, N. Biol. Reprod. (2000) [Pubmed]
  30. Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2. Resendes, A.R., Majó, N., Segalés, J., Mateu, E., Calsamiglia, M., Domingo, M. J. Gen. Virol. (2004) [Pubmed]
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