The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Dopexamina     4-[2-[6-(phenethylamino) hexylamino]ethyl]b...

Synonyms: Dopexamine, Dopexaminum, CHEMBL77622, SureCN122233, FPL-60278, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FPL 60278

  • In this multicenter, parallel design, placebo-controlled study, 45 patients with functional class III or IV chronic congestive heart failure were randomized to receive a placebo infusion or one of three different doses of dopexamine [1].
  • During this 6-h period, dopexamine was infused at rates of 1, 2 and 4 micrograms/kg body weight per min in the low, intermediate and high dose groups, respectively [1].
  • Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine [2].
  • Protecting the gut and the liver in the critically ill: effects of dopexamine [3].
  • The main effect of dopexamine infusion in the sepsis group was the attenuation of the rhythmic blood flow patterns (flow motion) observed during saline infusion [4].

High impact information on FPL 60278


Chemical compound and disease context of FPL 60278


Biological context of FPL 60278

  • In patients randomized to receive dopexamine, right atrial, systemic arterial, pulmonary artery and pulmonary capillary wedge pressures showed minimal change from baseline and did not differ statistically from the placebo response [1].
  • Then dopexamine infusion was titrated (1-4 microg x kg(-1) x min(-1)) to increase cardiac output by approximately 25% (20-30%) [7].
  • The study demonstrates the mechanism of action of dopexamine on cardiac function and peripheral perfusion during cardiac surgery and shows that the inodilator properties during cardiac surgery are useful haemodynamically and facilitate early reversal of tissue hypoperfusion and oxygen debt in this environment [12].
  • The study demonstrated that dopexamine significantly increased cardiac index compared with the control group (P < 0.05) and that this effect was mediated through an increase in both left ventricular stroke volume index and heart rate (P < 0.05) [12].
  • Dopexamine increased mean arterial pressure, heart rate, and hindlimb blood flow during anaesthesia in controls, but not in CHF [13].

Anatomical context of FPL 60278


Associations of FPL 60278 with other chemical compounds


Gene context of FPL 60278


Analytical, diagnostic and therapeutic context of FPL 60278


  1. Efficacy and safety of a short-term (6-h) intravenous infusion of dopexamine in patients with severe congestive heart failure: a randomized, double-blind, parallel, placebo-controlled multicenter study. Gollub, S.B., Elkayam, U., Young, J.B., Miller, L.W., Haffey, K.A. J. Am. Coll. Cardiol. (1991) [Pubmed]
  2. Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine. Temmesfeld-Wollbrück, B., Szalay, A., Mayer, K., Olschewski, H., Seeger, W., Grimminger, F. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  3. Protecting the gut and the liver in the critically ill: effects of dopexamine. Smithies, M., Yee, T.H., Jackson, L., Beale, R., Bihari, D. Crit. Care Med. (1994) [Pubmed]
  4. Dopexamine attenuates flow motion in ileal mucosal arterioles in normotensive sepsis. Madorin, W.S., Martin, C.M., Sibbald, W.J. Crit. Care Med. (1999) [Pubmed]
  5. Human internal thoracic artery reactivity to dopaminergic agents. Myers, M.L., Li, G.H., Yaghi, A., McCormack, D. Circulation (1993) [Pubmed]
  6. Laser Doppler flowmetry is useful in the clinical management of small bowel transplantation. The Liver Transplant Group. Corbett, E.J., Barry, B.N., Pollard, S.G., Lodge, J.P., Bellamy, M.C. Gut (2000) [Pubmed]
  7. Effect of a dopexamine-induced increase in cardiac index on splanchnic hemodynamics in septic shock. Kiefer, P., Tugtekin, I., Wiedeck, H., Bracht, H., Geldner, G., Georgieff, M., Radermacher, P. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  8. Effects of dobutamine and dopexamine on hepatic micro- and macrocirculation during experimental endotoxemia: an intravital microscopic study in the rat. Secchi, A., Ortanderl , J.M., Schmidt, W., Walther, A., Gebhard, M.M., Martin, E., Schmidt, H. Crit. Care Med. (2001) [Pubmed]
  9. Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors. Brown, R.A., Dixon, J., Farmer, J.B., Hall, J.C., Humphries, R.G., Ince, F., O'Connor, S.E., Simpson, W.T., Smith, G.W. Br. J. Pharmacol. (1985) [Pubmed]
  10. Effect of dopexamine on intestinal tissue concentrations of high-energy phosphates and intestinal release of purine compounds in endotoxemic rats. Schmidt, H., Weigand, M.A., Schmidt, W., Plaschke, K., Martin, E., Bardenheuer, H.J. Crit. Care Med. (2000) [Pubmed]
  11. Adrenergic agents modify cerebral edema and microvessel ultrastructure in porcine sepsis. Moss, R.F., Parmar, N.K., Tighe, D., Davies, D.C. Crit. Care Med. (2004) [Pubmed]
  12. The haemodynamic effect of prophylactic peri-operative dopexamine in coronary artery bypass patients. Hurley, J., McDonagh, P., Cahill, M., White, M., Luke, D., McGovern, E., Phelan, D. Eur. Heart J. (1995) [Pubmed]
  13. Regional blood flow effects of dopexamine versus enalaprilat during propofol anaesthesia in rabbits with experimental chronic heart failure. Blake, D.W., Way, D., Trigg, L., McGrath, B.P. Cardiovasc. Res. (1994) [Pubmed]
  14. Dopexamine hydrochloride in the human heart: receptor binding and effects on cAMP generation. Napoleone, P., Ricci, A., Ferrante, F., Amenta, F. Eur. Heart J. (1992) [Pubmed]
  15. Inotropic treatment and intestinal mucosal tissue oxygenation in a model of porcine endotoxemia. Germann, R., Haisjackl, M., Schwarz, B., Deusch, E., Meusburger, S., Gruber, E., Pajk, W., Hausdorfer, H., Bonatti, J., Furtner, B., Ulmer, H., Hasibeder, W. Crit. Care Med. (1997) [Pubmed]
  16. Dopexamine attenuates endotoxin-induced microcirculatory changes in rat mesentery: role of beta2 adrenoceptors. Schmidt, W., Häcker, A., Gebhard, M.M., Martin, E., Schmidt, H. Crit. Care Med. (1998) [Pubmed]
  17. Effect of pharmacological interventions in the prevention of lipid peroxidation and respiratory depression induced by oxygen free radicals in anesthetized rats. Jacinto, S.M., Lokhandwala, M.F., Jandhyala, B.S. Free Radic. Biol. Med. (1996) [Pubmed]
  18. Goal-directed therapy with dopexamine, dobutamine, and volume expansion: effects of systemic oxygen transport on hepatic ultrastructure in porcine sepsis. Tighe, D., Moss, R., Heywood, G., al-Saady, N., Webb, A., Bennett, D. Crit. Care Med. (1995) [Pubmed]
  19. Dopexamine but not dopamine increases gastric mucosal oxygenation during mechanical ventilation in dogs. Scheeren, T.W., Schwarte, L.A., Loer, S.A., Picker, O., Fournell, A. Crit. Care Med. (2002) [Pubmed]
  20. Metabolic and calorigenic effects of dopexamine in healthy volunteers. Geisser, W., Träger, K., Hähn, A., Georgieff, M., Ensinger, H. Crit. Care Med. (1997) [Pubmed]
  21. Effects of dopexamine on creatinine clearance, systemic inflammation, and splanchnic oxygenation in patients undergoing coronary artery bypass grafting. Berendes, E., Möllhoff, T., Van Aken, H., Schmidt, C., Erren, M., Deng, M.C., Weyand, M., Loick, H.M. Anesth. Analg. (1997) [Pubmed]
  22. Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury. Dhingra, V.K., Uusaro, A., Holmes, C.L., Walley, K.R. Anesthesiology (2001) [Pubmed]
  23. Dopexamine reverses colonic but not gastric mucosal perfusion defects in lethal endotoxin shock. Tenhunen, J.J., Martikainen, T.J., Uusaro, A., Ruokonen, E. British journal of anaesthesia. (2003) [Pubmed]
  24. Short-term haemodynamic effects of dopexamine in patients with chronic congestive heart failure. Svensson, G., Sjögren, A., Erhardt, L. Eur. Heart J. (1986) [Pubmed]
  25. Dopexamine improves liver oxygenation during crystalloid resuscitation from experimental hemorrhagic shock. Nordin, A., Mäkisalo, H., Mildh, L., Höckerstedt, K. Crit. Care Med. (1997) [Pubmed]
  26. Cardiovascular actions of dopexamine in anaesthetized and conscious dogs. Einstein, R., Abdul-Hussein, N., Wong, T.W., Chang, D.H., Matthews, R., Richardson, D.P. Br. J. Pharmacol. (1994) [Pubmed]
WikiGenes - Universities