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Gene Review

B3gat1  -  beta-1,3-glucuronyltransferase 1...

Mus musculus

Synonyms: 0710007K08Rik, AI846286, Beta-1,3-glucuronyltransferase 1, Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, GlcAT-P, ...
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Disease relevance of B3gat1


High impact information on B3gat1


Biological context of B3gat1


Anatomical context of B3gat1


Associations of B3gat1 with chemical compounds

  • The HNK-1 glycan synthesis is initiated by the addition of beta1,3-linked GlcA to N-acetyllactosamine followed by sulfation of the C-3 position of GlcA [9].
  • The most straightforward interpretation of these observations is that the L2/HNK-1 carbohydrate and the sulfated carbohydrates, sulfatide and heparin, act as ligands in cell adhesion [10].
  • These results suggested that the HNK-1 carbohydrate without sulfate (non-sulfated HNK-1 carbohydrate) is expressed in the kidney [15].
  • The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed characteristically on a series of cell adhesion molecules and is synthesized through a key enzyme, glucuronyltransferase (GlcAT-P) [11].
  • The characteristic structural feature of the HNK-1 carbohydrate is 3-sulfo-glucuronyl residues attached to lactosamine structures (Gal beta1-4GlcNAc) on glycoproteins and glycolipids [15].

Other interactions of B3gat1

  • By contrast, HNK-1 glycan was much more efficiently added to N-glycans than O-glycans when NCAM was used as an acceptor [9].
  • Using synthetic oligosaccharides as acceptors, we found that GlcAT-P and HNK-1ST almost equally act on oligosaccharides, mimicking N- and O-glycans [9].
  • This is the first study indicating the presence of the non-sulfated HNK-1 carbohydrate being synthesized by GlcAT-S in the kidney [15].
  • These results provide first evidence that tenascin-R and its associated HNK-1 carbohydrate modulate perisomatic inhibition and synaptic plasticity in the hippocampus [16].
  • This protein is post-translationally modified with oligosaccharides, including the HNK-1 epitope, but, unlike phosphacan, it is not a proteoglycan [17].

Analytical, diagnostic and therapeutic context of B3gat1

  • Since indirect evidence indicated that the L2/HNK-1 carbohydrate is not present on all molecules within a particular species of glycoproteins, it seemed pertinent to investigate this more directly by sequential immunoprecipitations [18].
  • Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitope [19].
  • HNK-1 immunohistochemistry revealed that clusters of HNK-1-positive cells (presumptive migrating neural crest cells) are frequently located around the developing eyes and in the posterior region of the silver embryonic eye [20].
  • These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R [21].
  • Western blot analyses of the neural cell adhesion molecules (N-CAMs) during development of the rat cortex with a polyclonal anti-N-CAM antibody showed that the major HNK-1-reactive protein bands were not N-CAMs [22].


  1. The HNK-1 reactive sulfoglucuronyl glycolipids are ligands for L-selectin and P-selectin but not E-selectin. Needham, L.K., Schnaar, R.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Regulation of expression of sulfoglucuronyl carbohydrate (HNK-1), Amphoterin and RAGE in retinoic acid-differentiated P19 embryonal carcinoma cells. Chou, D.K., Henion, T.R., Jungalwala, F.B. J. Neurochem. (2003) [Pubmed]
  3. The epitope(s) recognized by HNK-1 antibody and IgM paraprotein in neuropathy is present on several N-linked oligosaccharide structures on human P0 and myelin-associated glycoprotein. Burger, D., Simon, M., Perruisseau, G., Steck, A.J. J. Neurochem. (1990) [Pubmed]
  4. Neuronal influence on antigenic marker profile, cell shape and proliferation of cultured astrocytes obtained by microdissection of distinct layers from the early postnatal mouse cerebellum. Nagata, I., Keilhauer, G., Schachner, M. Brain Res. (1986) [Pubmed]
  5. The J1 glycoprotein--a novel nervous system cell adhesion molecule of the L2/HNK-1 family. Kruse, J., Keilhauer, G., Faissner, A., Timpl, R., Schachner, M. Nature (1985) [Pubmed]
  6. Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1. Kruse, J., Mailhammer, R., Wernecke, H., Faissner, A., Sommer, I., Goridis, C., Schachner, M. Nature (1984) [Pubmed]
  7. Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1. McGarry, R.C., Helfand, S.L., Quarles, R.H., Roder, J.C. Nature (1983) [Pubmed]
  8. Interaction of astrochondrin with extracellular matrix components and its involvement in astrocyte process formation and cerebellar granule cell migration. Streit, A., Nolte, C., Rásony, T., Schachner, M. J. Cell Biol. (1993) [Pubmed]
  9. Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM. Ong, E., Suzuki, M., Belot, F., Yeh, J.C., Franceschini, I., Angata, K., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (2002) [Pubmed]
  10. The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions. Künemund, V., Jungalwala, F.B., Fischer, G., Chou, D.K., Keilhauer, G., Schachner, M. J. Cell Biol. (1988) [Pubmed]
  11. Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. Yamamoto, S., Oka, S., Inoue, M., Shimuta, M., Manabe, T., Takahashi, H., Miyamoto, M., Asano, M., Sakagami, J., Sudo, K., Iwakura, Y., Ono, K., Kawasaki, T. J. Biol. Chem. (2002) [Pubmed]
  12. Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach. Thomas, S.N., Soreghan, B.A., Nistor, M., Sarsoza, F., Head, E., Yang, A.J. J. Neurochem. (2005) [Pubmed]
  13. Specific expression of an HNK-1 carbohydrate epitope and NCAM on femoral nerve Schwann cells in mice. Saito, H., Nakao, Y., Takayama, S., Toyama, Y., Asou, H. Neurosci. Res. (2005) [Pubmed]
  14. Regulation of neural cell adhesion molecule expression on cultured mouse Schwann cells by nerve growth factor. Seilheimer, B., Schachner, M. EMBO J. (1987) [Pubmed]
  15. A non-sulfated form of the HNK-1 carbohydrate is expressed in mouse kidney. Tagawa, H., Kizuka, Y., Ikeda, T., Itoh, S., Kawasaki, N., Kurihara, H., Onozato, M.L., Tojo, A., Sakai, T., Kawasaki, T., Oka, S. J. Biol. Chem. (2005) [Pubmed]
  16. The extracellular matrix molecule tenascin-R and its HNK-1 carbohydrate modulate perisomatic inhibition and long-term potentiation in the CA1 region of the hippocampus. Saghatelyan, A.K., Gorissen, S., Albert, M., Hertlein, B., Schachner, M., Dityatev, A. Eur. J. Neurosci. (2000) [Pubmed]
  17. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. Garwood, J., Heck, N., Reichardt, F., Faissner, A. J. Biol. Chem. (2003) [Pubmed]
  18. Monoclonal antibody detects carbohydrate microheterogeneity on the murine cell adhesion molecule L1. Faissner, A. Neurosci. Lett. (1987) [Pubmed]
  19. Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitope. Yamamoto, S., Oka, S., Saito-Ohara, F., Inazawa, J., Kawasaki, T. J. Biochem. (2002) [Pubmed]
  20. Epithelia-mesenchyme interaction plays an essential role in transdifferentiation of retinal pigment epithelium of silver mutant quail: localization of FGF and related molecules and aberrant migration pattern of neural crest cells during eye rudiment formation. Araki, M., Takano, T., Uemonsa, T., Nakane, Y., Tsudzuki, M., Kaneko, T. Dev. Biol. (2002) [Pubmed]
  21. Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. Gurevicius, K., Gureviciene, I., Sivukhina, E., Irintchev, A., Schachner, M., Tanila, H. Mol. Cell. Neurosci. (2007) [Pubmed]
  22. Developmental expression of HNK-1-reactive antigens in rat cerebral cortex and molecular heterogeneity of sulfoglucuronylneolactotetraosylceramide in CNS versus PNS. Chou, D.K., Prasadarao, N., Koul, O., Jungalwala, F.B. J. Neurochem. (1991) [Pubmed]
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