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Gene Review

Fabp3  -  fatty acid binding protein 3, muscle and...

Rattus norvegicus

Synonyms: Fatty acid-binding protein 3, Fatty acid-binding protein, heart, H-FABP, Heart-type fatty acid-binding protein
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Disease relevance of Fabp3

  • We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis and c-jun expression [1].
  • In order to explore the function of aortic H-FABP, we examined whether a quantitative change in aortic H-FABP occurred in diabetes mellitus, since this pathological state has been shown to cause abnormalities in fatty acid metabolism [2].
  • It was observed that as early as 15 min after ischemia, the depletion of H-FABP could be detected in model rats [3].
  • In all human cases with myocardial infarction, absent H-FABP staining could be found in infarcted area [3].
  • One-step purification of rat heart-type fatty acid-binding protein expressed in Escherichia coli [4].

High impact information on Fabp3


Chemical compound and disease context of Fabp3

  • Mepacrine, a membrane stabilizer and a phospholipase inhibitor, reduced the release of H-FABP from the heart and prevented the accumulation of nonesterified fatty acids in the tissue during ischemia and reperfusion [9].

Biological context of Fabp3


Anatomical context of Fabp3


Associations of Fabp3 with chemical compounds

  • Transfer of 2AP from HFABP mutants involving K22, located on alpha-helix I (alpha-I) of the helical cap region, was 3-fold slower than transfer from wild-type protein, whereas rates from a mutant involving the K59 residue, located on the beta 2-turn of the barrel near the helical cap, were 2-fold faster than those of wild type [10].
  • In the present study, the expression of H-FABP was measured in red and white skeletal muscle under two conditions in which fatty acid utilization is known to be increased: streptozotocin-induced diabetes and fasting [12].
  • The ratio of [14C]palmitic acid incorporation into phosphatidylcholine and phosphatidylethanolamine of A-FABP-cDNA-transfected clones changed in the opposite direction in differentiation medium from that of mock- and H-FABP-cDNA-transfected clones [11].
  • To directly examine the role of charged lysine residues on the HFABP surface in specific interactions with membranes, chemical modification and selective mutagenesis of HFABP were used [10].
  • Therefore, the stimulatory effect of cold exposure on the transcript of H-FABP in BAT was concluded to be mediated by NE, like that of the uncoupling protein (UCP) [14].

Other interactions of Fabp3

  • H-FABP immunoreactivity was first detected at embryonic day 20 (E20), with predominant localization in the parietal cells, whereas I-FABP immunoreactivity was detected at the day of birth in the surface mucous cells [15].
  • Interestingly, we found that both HFABP and UCP2 mRNA levels were significantly reduced in cafeteria-obese rats when compared to control animals [16].
  • Highly sensitive immunochemical assays (sandwich ELISAs) using specific antibodies raised against rat H- or L-FABP showed the contents of these FABP-types in endothelial cells to be 1-5 ng/mg cytosolic protein, which is more than three orders of magnitude lower than the contents of H-FABP in heart or L-FABP in liver [13].
  • In the presence of DEHP, MEHP, and EHA, the expression of PPARalpha, PPARgamma, FATP1, and HFABP were up-regulated in a dose- and time- dependent manner, while PPARbeta and FABPpm demonstrated variable expression [17].

Analytical, diagnostic and therapeutic context of Fabp3


  1. Heart fatty acid binding protein is a novel regulator of cardiac myocyte hypertrophy. Burton, P.B., Hogben, C.E., Joannou, C.L., Clark, A.G., Hsuan, J.J., Totty, N.F., Sorensen, C., Evans, R.W., Tynan, M.J. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  2. Tissue-specific suppression of aortic fatty-acid-binding protein in streptozotocin-induced diabetic rats. Sakai, K., Fujii, H., Yamamoto, T., Sakakibara, J., Izumi, T., Shibata, A., Ono, T. Eur. J. Biochem. (1995) [Pubmed]
  3. Heart fatty acid binding protein as a marker for postmortem detection of early myocardial damage. Meng, X., Ming, M., Wang, E. Forensic Sci. Int. (2006) [Pubmed]
  4. One-step purification of rat heart-type fatty acid-binding protein expressed in Escherichia coli. Schaap, F.G., Specht, B., van der Vusse, G.J., Börchers, T., Glatz, J.F. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  5. Mechanism of free fatty acid transfer from rat heart fatty acid-binding protein to phospholipid membranes. Evidence for a collisional process. Kim, H.K., Storch, J. J. Biol. Chem. (1992) [Pubmed]
  6. Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Wu, Y., Liu, Z., Xiang, Z., Zeng, C., Chen, Z., Ma, X., Li, L. Endocrinology (2006) [Pubmed]
  7. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. Widstrom, R.L., Norris, A.W., Spector, A.A. Biochemistry (2001) [Pubmed]
  8. Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes. van der Lee, K.A., Vork, M.M., De Vries, J.E., Willemsen, P.H., Glatz, J.F., Reneman, R.S., Van der Vusse, G.J., Van Bilsen, M. J. Lipid Res. (2000) [Pubmed]
  9. Release of fatty acid-binding protein from ischemic-reperfused rat heart and its prevention by mepacrine. Das, D.K., Barua, P.K., Jones, R.M. Biochim. Biophys. Acta (1991) [Pubmed]
  10. Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes. Herr, F.M., Aronson, J., Storch, J. Biochemistry (1996) [Pubmed]
  11. Transfection of L6 myoblasts with adipocyte fatty acid-binding protein cDNA does not affect fatty acid uptake but disturbs lipid metabolism and fusion. Prinsen, C.F., Veerkamp, J.H. Biochem. J. (1998) [Pubmed]
  12. Transcriptional regulation of muscle fatty acid-binding protein. Carey, J.O., Neufer, P.D., Farrar, R.P., Veerkamp, J.H., Dohm, G.L. Biochem. J. (1994) [Pubmed]
  13. Fatty acid transfer across the myocardial capillary wall: no evidence of a substantial role for cytoplasmic fatty acid-binding protein. Van Nieuwenhoven, F.A., Verstijnen, C.P., Van Eys, G.J., Van Breda, E., De Jong, Y.F., Van der Vusse, G.J., Glatz, J.F. J. Mol. Cell. Cardiol. (1994) [Pubmed]
  14. Dramatic enhancement of the specific expression of the heart-type fatty acid binding protein in rat brown adipose tissue by cold exposure. Daikoku, T., Shinohara, Y., Shima, A., Yamazaki, N., Terada, H. FEBS Lett. (1997) [Pubmed]
  15. Ontogenic appearance of three fatty acid binding proteins in the rat stomach. Iseki, S., Kanda, T., Hitomi, M., Ono, T. Anat. Rec. (1991) [Pubmed]
  16. Down-regulation of heart HFABP and UCP2 gene expression in diet-induced (cafeteria) obese rats. Marti, A., Vaquerizo, J., Zulet, M.A., Moreno-Aliaga, M.J., Martínez, J.A. Journal of physiology and biochemistry. (2002) [Pubmed]
  17. Effects of di-(2-ethylhexyl)-phthalate (DEHP) and its metabolites on fatty acid homeostasis regulating proteins in rat placental HRP-1 trophoblast cells. Xu, Y., Cook, T.J., Knipp, G.T. Toxicol. Sci. (2005) [Pubmed]
  18. Effects of aging and denervation on the expression of uncoupling proteins in slow- and fast-twitch muscles of rats. Kontani, Y., Wang, Z., Furuyama, T., Sato, Y., Mori, N., Yamashita, H. J. Biochem. (2002) [Pubmed]
  19. A sandwich enzyme linked immuno-sorbent assay for the determination of rat heart fatty acid-binding protein using the streptavidin-biotin system. Application to tissue and effluent samples from normoxic rat heart perfusion. Vork, M.M., Glatz, J.F., Surtel, D.A., Knubben, H.J., Van der Vusse, G.J. Biochim. Biophys. Acta (1991) [Pubmed]
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