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FABP3  -  fatty acid binding protein 3, muscle and...

Homo sapiens

Synonyms: FABP11, Fatty acid-binding protein 3, Fatty acid-binding protein, heart, H-FABP, Heart-type fatty acid-binding protein, ...
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Disease relevance of FABP3


Psychiatry related information on FABP3


High impact information on FABP3


Chemical compound and disease context of FABP3


Biological context of FABP3


Anatomical context of FABP3


Associations of FABP3 with chemical compounds


Physical interactions of FABP3


Regulatory relationships of FABP3


Other interactions of FABP3

  • A comparison of the three-dimensional structure of human muscle fatty acid-binding protein and rat intestinal fatty acid-binding protein shows strong similarity [25].
  • In adult brain, B-FABP was significantly increased in occipital cortex of DS, and H-FABP was significantly decreased in DS (frontal, occipital and parietal cortices) and AD (frontal, temporal, occipital and parietal cortices) [4].
  • The finding that the change in UCP3 protein content correlates with the change in skeletal muscle fatty acid-binding protein content, suggests a role for UCPs in the handling of lipids as a fuel [26].
  • In ECT, serum B-FABP was increased in 6% of all samples (2 of 14 patients), whereas H-FABP was above its upper reference limit (6 microg/L) in 17% of all samples (8 of 14 patients), and S100B was above its upper reference limit (0.3 microg/L) in 0.4% of all samples [6].
  • A scenario is discussed in which FABPpm, FAT/CD36, and H-FABP, probably assisted by an albumin-binding protein, cooperate in the translocation of FA across the sarcolemma [27].

Analytical, diagnostic and therapeutic context of FABP3

  • By logistic and multiple regression analysis, one insertion/deletion polymorphism in the 3' end (c.634+483delT) of FABP3 appeared to be weakly associated with increased risk of type 2 diabetes (OR=1.78-1.94, P=0.03-0.04) and waist/hip ratio (WHR) (P=0.03) [1].
  • METHODS: Immunohistochemistry with anti-H-FABP antibody was performed in 669 gastric carcinomas and 60 tubular adenomas of the stomach [17].
  • Evaluation of a strategy combining biomarker testing with echocardiography revealed that patients with a negative H-FABP test had an excellent prognosis regardless of echocardiographic findings [28].
  • CONCLUSION: Serum H-FABP is a potential independent predictor of cardiac events within 6 months of patient admission and may provide prognostic information superior to cTnT in the early hours of ACS [29].
  • METHODS: Serum concentrations of H-FABP and cTnT were measured on admission in 328 consecutive patients hospitalized for ACS within 6 h after the onset of chest pain [AMI, 241 (73.5%) patients; ST-segment elevation myocardial infarction, 154 (47.0%) patients; and emergent coronary angiography within 24 h after admission, 287 (87.5%) patients] [29].


  1. Polymorphisms in fatty acid-binding protein-3 (FABP3) - putative association with type 2 diabetes mellitus. Shin, H.D., Kim, L.H., Park, B.L., Jung, H.S., Cho, Y.M., Moon, M.K., Lee, H.K., Park, K.S. Hum. Mutat. (2003) [Pubmed]
  2. Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor. Huynh, H.T., Larsson, C., Narod, S., Pollak, M. Cancer Res. (1995) [Pubmed]
  3. Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct. Watanabe, K., Wakabayashi, H., Veerkamp, J.H., Ono, T., Suzuki, T. J. Pathol. (1993) [Pubmed]
  4. Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer's disease. Cheon, M.S., Kim, S.H., Fountoulakis, M., Lubec, G. J. Neural Transm. Suppl. (2003) [Pubmed]
  5. A genetically engineered fusion protein with horseradish peroxidase as a marker enzyme for use in competitive immunoassays. Grigorenko, V., Andreeva, I., Börchers, T., Spener, F., Egorov, A. Anal. Chem. (2001) [Pubmed]
  6. Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility. Pelsers, M.M., Hanhoff, T., Van der Voort, D., Arts, B., Peters, M., Ponds, R., Honig, A., Rudzinski, W., Spener, F., de Kruijk, J.R., Twijnstra, A., Hermens, W.T., Menheere, P.P., Glatz, J.F. Clin. Chem. (2004) [Pubmed]
  7. Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases. Steinacker, P., Mollenhauer, B., Bibl, M., Cepek, L., Esselmann, H., Brechlin, P., Lewczuk, P., Poser, S., Kretzschmar, H.A., Wiltfang, J., Trenkwalder, C., Otto, M. Neurosci. Lett. (2004) [Pubmed]
  8. Members of the fatty acid binding protein family are differentiation factors for the mammary gland. Yang, Y., Spitzer, E., Kenney, N., Zschiesche, W., Li, M., Kromminga, A., Müller, T., Spener, F., Lezius, A., Veerkamp, J.H. J. Cell Biol. (1994) [Pubmed]
  9. Silencing of the mammary-derived growth inhibitor (MDGI) gene in breast neoplasms is associated with epigenetic changes. Huynh, H., Alpert, L., Pollak, M. Cancer Res. (1996) [Pubmed]
  10. Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria. Ehrhardt, S., Wichmann, D., Hemmer, C.J., Burchard, G.D., Brattig, N.W. Trop. Med. Int. Health (2004) [Pubmed]
  11. The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells. Xu, Y., Mirmalek-Sani, S.H., Yang, X., Zhang, J., Oreffo, R.O. Exp. Cell Res. (2006) [Pubmed]
  12. Identification of a human heart FABP pseudogene located on chromosome 13. Prinsen, C.F., Weghuis, D.O., Kessel, A.G., Veerkamp, J.H. Gene (1997) [Pubmed]
  13. Structure, linkage mapping and expression of the heart-type fatty acid-binding protein gene (fabp3 ) from zebrafish (Danio rerio). Liu, R.Z., Denovan-Wright, E.M., Wright, J.M. Eur. J. Biochem. (2003) [Pubmed]
  14. Dinucleotide repeat in the third intron of the FABP3/MDGI putative tumor suppressor gene. Arlt, M.F., Goodfellow, P.J., Rottman, J.N. Dis. Markers (1996) [Pubmed]
  15. Fatty acid binding protein 4 in human skeletal muscle. Fischer, H., Gustafsson, T., Sundberg, C.J., Norrbom, J., Ekman, M., Johansson, O., Jansson, E. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  16. Characteristics of fatty acid-binding proteins and their relation to mammary-derived growth inhibitor. Spener, F., Unterberg, C., Börchers, T., Grosse, R. Mol. Cell. Biochem. (1990) [Pubmed]
  17. Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis. Hashimoto, T., Kusakabe, T., Sugino, T., Fukuda, T., Watanabe, K., Sato, Y., Nashimoto, A., Honma, K., Kimura, H., Fujii, H., Suzuki, T. Pathobiology (2004) [Pubmed]
  18. Use of cytosolic and myofibril markers in the detection of ongoing myocardial damage in patients with chronic heart failure. Setsuta, K., Seino, Y., Ogawa, T., Arao, M., Miyatake, Y., Takano, T. Am. J. Med. (2002) [Pubmed]
  19. Protein-ligand NOE matching: a high-throughput method for binding pose evaluation that does not require protein NMR resonance assignments. Constantine, K.L., Davis, M.E., Metzler, W.J., Mueller, L., Claus, B.L. J. Am. Chem. Soc. (2006) [Pubmed]
  20. Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids. Young, A.C., Scapin, G., Kromminga, A., Patel, S.B., Veerkamp, J.H., Sacchettini, J.C. Structure (1994) [Pubmed]
  21. Stabilization of mammary-derived growth inhibitor messenger RNA by antiestrogens. Huynh, H., Pollak, M. Clin. Cancer Res. (1997) [Pubmed]
  22. Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma. Park, K.S., Ciaraldi, T.P., Lindgren, K., Abrams-Carter, L., Mudaliar, S., Nikoulina, S.E., Tufari, S.R., Veerkamp, J.H., Vidal-Puig, A., Henry, R.R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  23. Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog. Baillie, A.G., Coburn, C.T., Abumrad, N.A. J. Membr. Biol. (1996) [Pubmed]
  24. Expression of human liver fatty acid-binding protein in Escherichia coli and comparative analysis of its binding characteristics with muscle fatty acid-binding protein. Maatman, R.G., van Moerkerk, H.T., Nooren, I.M., van Zoelen, E.J., Veerkamp, J.H. Biochim. Biophys. Acta (1994) [Pubmed]
  25. Three-dimensional structure of recombinant human muscle fatty acid-binding protein. Zanotti, G., Scapin, G., Spadon, P., Veerkamp, J.H., Sacchettini, J.C. J. Biol. Chem. (1992) [Pubmed]
  26. The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects. Schrauwen, P., Schaart, G., Saris, W.H., Slieker, L.J., Glatz, J.F., Vidal, H., Blaak, E.E. Diabetologia (2000) [Pubmed]
  27. Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins. Luiken, J.J., Schaap, F.G., van Nieuwenhoven, F.A., van der Vusse, G.J., Bonen, A., Glatz, J.F. Lipids (1999) [Pubmed]
  28. Heart-type fatty acid-binding protein permits early risk stratification of pulmonary embolism. Puls, M., Dellas, C., Lankeit, M., Olschewski, M., Binder, L., Geibel, A., Reiner, C., Schäfer, K., Hasenfuss, G., Konstantinides, S. Eur. Heart J. (2007) [Pubmed]
  29. Prognostic value of serum concentration of heart-type fatty acid-binding protein relative to cardiac troponin T on admission in the early hours of acute coronary syndrome. Ishii, J., Ozaki, Y., Lu, J., Kitagawa, F., Kuno, T., Nakano, T., Nakamura, Y., Naruse, H., Mori, Y., Matsui, S., Oshima, H., Nomura, M., Ezaki, K., Hishida, H. Clin. Chem. (2005) [Pubmed]
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