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Dbn1  -  drebrin 1

Rattus norvegicus

Synonyms: Developmentally-regulated brain protein, Drebrin
 
 
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Disease relevance of Dbn1

 

Psychiatry related information on Dbn1

  • We investigated the effects of drebrin in vivo knockdown on spatial memory in a water-maze task, sensorimotor gating in a pre-pulse-inhibition test, adaptive behaviors in an open-field test, and sensitivity to psychostimulant in an amphetamine-induced locomotor response [1].
  • Rats with drebrin A in vivo knockdown displayed a stronger preference for a previous event due to perseverative behavior, impaired pre-pulse inhibition (PPI), increased locomotor activity, anxiety-like behavior, and an increased sensitivity to psychostimulant, suggesting behaviors related to schizophrenia [1].
 

High impact information on Dbn1

 

Biological context of Dbn1

 

Anatomical context of Dbn1

  • These results demonstrate that drebrin A accumulates spine-resident proteins via protein-protein interaction in filopodia, and suggest that the spine formation requires the concurrence of the increase of drebrin-A expression and the functional presynaptic contact [9].
  • In this study, we expressed drebrin A tagged with green fluorescent protein (GFP-DA) in hippocampal neurons at 7-9 days in vitro when presynaptic terminals are not fully maturated [4].
  • Here we examine the molecular mechanisms responsible for the changes in spine morphology, focusing on drebrin, an actin-binding protein that is known to change the properties of actin filaments [2].
  • Drebrin is a development-associated neuroprotein whose cDNA into fibroblasts causes the formation of dendrite-like structures (Shirao, T., Kojima, N., and Obata, K. (1992) Neuroreport 3, 109-112) [5].
  • Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones [10].
 

Associations of Dbn1 with chemical compounds

 

Physical interactions of Dbn1

 

Regulatory relationships of Dbn1

  • Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions [9].
 

Other interactions of Dbn1

  • In contrast, no changes occurred during the course of IH exposures in the expression of the synaptic proteins synaptophysin, SNAP25, and drebrin [12].
  • The adult-type isoform of drebrin was detected by Western blotting after seventh day in primary cultured cortical neurons and the expression was coincidental with that of synaptophysin [13].
  • These data indicated that the synaptic clustering of drebrin is necessary for that of PSD-95 in developing neurons [8].
 

Analytical, diagnostic and therapeutic context of Dbn1

References

  1. Antisense knockdown of drebrin A, a dendritic spine protein, causes stronger preference, impaired pre-pulse inhibition, and an increased sensitivity to psychostimulant. Kobayashi, R., Sekino, Y., Shirao, T., Tanaka, S., Ogura, T., Inada, K., Saji, M. Neurosci. Res. (2004) [Pubmed]
  2. Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. Hayashi, K., Ishikawa, R., Ye, L.H., He, X.L., Takata, K., Kohama, K., Shirao, T. J. Neurosci. (1996) [Pubmed]
  3. Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1. Fucini, R.V., Chen, J.L., Sharma, C., Kessels, M.M., Stamnes, M. Mol. Biol. Cell (2002) [Pubmed]
  4. Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions. Mizui, T., Takahashi, H., Sekino, Y., Shirao, T. Mol. Cell. Neurosci. (2005) [Pubmed]
  5. Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments. Ishikawa, R., Hayashi, K., Shirao, T., Xue, Y., Takagi, T., Sasaki, Y., Kohama, K. J. Biol. Chem. (1994) [Pubmed]
  6. Effect of a neuron-specific actin-binding protein, drebrin A, on cell-substratum adhesion. Ikeda, K., Shirao, T., Toda, M., Asada, H., Toya, S., Uyemura, K. Neurosci. Lett. (1995) [Pubmed]
  7. Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress. Yang, H.J., Li, Y.F., Zhang, H.T., Zhang, F.Q., Zhao, N., Gong, Z.H., Luo, Z.P. Neurosci. Lett. (2003) [Pubmed]
  8. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. Takahashi, H., Sekino, Y., Tanaka, S., Mizui, T., Kishi, S., Shirao, T. J. Neurosci. (2003) [Pubmed]
  9. Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions. Mizui, T., Takahashi, H., Sekino, Y., Shirao, T. Mol. Cell. Neurosci. (2005) [Pubmed]
  10. Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. Sasaki, Y., Hayashi, K., Shirao, T., Ishikawa, R., Kohama, K. J. Neurochem. (1996) [Pubmed]
  11. Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses. Aoki, C., Sekino, Y., Hanamura, K., Fujisawa, S., Mahadomrongkul, V., Ren, Y., Shirao, T. J. Comp. Neurol. (2005) [Pubmed]
  12. Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis. Gozal, D., Row, B.W., Gozal, E., Kheirandish, L., Neville, J.J., Brittian, K.R., Sachleben, L.R., Guo, S.Z. Eur. J. Neurosci. (2003) [Pubmed]
  13. Rapid conversion of drebrin isoforms during synapse formation in primary culture of cortical neurons. Hayashi, K., Suzuki, K., Shirao, T. Brain Res. Dev. Brain Res. (1998) [Pubmed]
 
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