The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lipf  -  lipase, gastric

Rattus norvegicus

Synonyms: GL, Gastric lipase, Gastric triacylglycerol lipase, Lingual lipase, RNLIP, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lipf


High impact information on Lipf


Chemical compound and disease context of Lipf


Biological context of Lipf


Anatomical context of Lipf

  • In contrast, the dorsal GL was disrupted, and Schwann cells were seen within the dorsal funiculus [14].
  • The ventral GL of the rat lumbosacral spinal cord is a more substantial structure than the dorsal GL during normal development [14].
  • However, our observations suggest that subpial astrocytes of the dorsal GL are more susceptible to radiation damage at three DP than the subpial astrocytes and radial glia of the ventral GL [14].
  • This inactivation is not prevented by colipase but is partially averted by lipids and protein, suggesting that lingual lipase can remain active in the duodenum [12].
  • A substantial portion of rat milk triglycerides was hydrolyzed in the ligated stomach of suckling rats with excised lingual gland and pancreas, due to the action of gastric lipase [15].

Associations of Lipf with chemical compounds

  • Purified rat lingual lipase (EC3113), a glycoprotein of approximate molecular weight 52,000, was used to generate polyclonal antibodies which were able to recognise the denatured and deglycosylated enzyme [7].
  • We focused on the gustatory sense and investigated the significance of lingual lipase in the perception of a fat taste by using orlistat, a potent lipase inhibitor [10].
  • Radioactive triolein applied on rats' circumvallate papilla revealed that lingual lipase was released continuously to generate significant amounts of fatty acids and other lipolytic products within 1-5 s, which was enough time to taste fat [10].
  • The effect of guanethidine was found to be transient, in that the lingual lipase activity showed complete recovery upon withdrawal of the treatment for 1 week [16].
  • The results suggest a unique bimodal regulation of lingual lipase by dexamethasone in the rat serous glands [17].

Regulatory relationships of Lipf


Other interactions of Lipf


Analytical, diagnostic and therapeutic context of Lipf


  1. Lingual lipase: an important lipase in the digestion of dietary lipids in cystic fibrosis? Fredrikzon, B., Bläckberg, L. Pediatr. Res. (1980) [Pubmed]
  2. Influence of the glia limitans on pial arteriolar relaxation in the rat. Xu, H.L., Koenig, H.M., Ye, S., Feinstein, D.L., Pelligrino, D.A. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  3. The role of gastric lipolysis on fat absorption and bile acid metabolism in the rat. Roy, C.C., Roulet, M., Lefebvre, D., Chartrand, L., Lepage, G., Fournier, L.A. Lipids (1979) [Pubmed]
  4. The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction. Okabe, H., Hasunuma, M., Hashimoto, Y. Pharm. Res. (2003) [Pubmed]
  5. Lingual lipase: immunocytochemical localization in the rat von Ebner gland. Roberts, I.M., Jaffe, R. Gastroenterology (1986) [Pubmed]
  6. Purification and characterization of rat lingual lipase. Field, R.B., Scow, R.O. J. Biol. Chem. (1983) [Pubmed]
  7. Molecular cloning and nucleotide sequence of rat lingual lipase cDNA. Docherty, A.J., Bodmer, M.W., Angal, S., Verger, R., Riviere, C., Lowe, P.A., Lyons, A., Emtage, J.S., Harris, T.J. Nucleic Acids Res. (1985) [Pubmed]
  8. Thyroidal regulation of lingual lipase development in suckling rats. Lee, P.C., Fu, C.L., Borysewicz, R., Werlin, S.L. Biol. Neonate (1993) [Pubmed]
  9. Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat. Fernandez, E., Borgström, B. Biochim. Biophys. Acta (1989) [Pubmed]
  10. Importance of lipolysis in oral cavity for orosensory detection of fat. Kawai, T., Fushiki, T. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  11. Studies on fat digestion, absorption, and transport in the suckling rat. II. Triacylglycerols: molecular species, stereospecific analysis, and specificity of hydrolysis by lingual lipase. Staggers, J.E., Fernando-Warnakulasuriya, G.J., Wells, M.A. J. Lipid Res. (1981) [Pubmed]
  12. Fat digestion by lingual lipase: mechanism of lipolysis in the stomach and upper small intestine. Liao, T.H., Hamosh, P., Hamosh, M. Pediatr. Res. (1984) [Pubmed]
  13. Molecular cloning of a human gastric lipase and expression of the enzyme in yeast. Bodmer, M.W., Angal, S., Yarranton, G.T., Harris, T.J., Lyons, A., King, D.J., Pieroni, G., Riviere, C., Verger, R., Lowe, P.A. Biochim. Biophys. Acta (1987) [Pubmed]
  14. Dorsal-ventral differences in the glia limitans of the spinal cord: an ultrastructural study in developing normal and irradiated rats. Sims, T.J., Gilmore, S.A., Waxman, S.G., Klinge, E. J. Neuropathol. Exp. Neurol. (1985) [Pubmed]
  15. Gastric lipase in the newborn rat. Levy, E., Goldstein, R., Freier, S., Shafrir, E. Pediatr. Res. (1982) [Pubmed]
  16. Developmental delay of lingual lipase expression after guanethidine-induced sympathectomy. Lee, P.C., Purcell, E.S., Borysewicz, R., Klein, R.M., Werlin, S.L. Proc. Soc. Exp. Biol. Med. (1992) [Pubmed]
  17. Modulation of lingual lipase development by glucocorticoid in the rat. Lee, P.C., Struve, M.F., Werlin, S.L. Pediatr. Res. (1991) [Pubmed]
  18. Neuromodulators of the lingual von Ebner gland: an immunocytochemical study. Roberts, I.M., Solomon, S.E., Brusco, O.A., Goldberg, W., Bernstein, J.J. Histochemistry (1991) [Pubmed]
  19. Effect of substance P and receptor antagonists on secretion of lingual lipase and amylase from rat von Ebner's gland. Field, R.B., Chirtel, S.J., Redman, R.S. Peptides (1997) [Pubmed]
  20. Decrease in contents of pancreatic carboxyl ester lipase, phospholipase A2, and lingual lipase in rats with streptozotocin-induced diabetes. Duan, R.D., Sternby, B. Scand. J. Gastroenterol. (1993) [Pubmed]
  21. Immunohistochemical localization and mRNA detection of Rab3D and/or Rab3B in rat von Ebner's glands, parotid gland, pancreas, and liver. Field, R.B., Kruse, D.H., Redman, R.S. Histochem. J. (2001) [Pubmed]
  22. The effects of histamine, pyrilamine, cimetidine, and ranitidine on secretion of lingual lipase and amylase from rat von Ebner's glands. Field, R.B., Chirtel, S.J. Agents Actions (1992) [Pubmed]
  23. Immunocytochemical localization of lingual lipase in serous cells of the developing rat tongue. Roberts, I.M., Nochomovitz, L.E., Jaffe, R., Hanel, S.I., Rojas, M., Agostini, R.A. Lipids (1987) [Pubmed]
WikiGenes - Universities