Disease relevance of LGALS12

• RESULTS: Grip strength was most strongly associated with birth weight in men (r = 0.19, p < .001) and women (r = 0.16, p < .001) [1].
• Limited impairments, probably due to peripheral neuropathy, were in evidence on the Grooved Pegboard, Finger Tapping (females), and Grip Strength (females) measures [2].
• PATIENTS: 92 children, born since 1976, who had meningomyelocele and hydrocephalus and were treated at the University of Rochester Medical Center. METHODS: Grip and pinch strength were measured between July, 1991, and June, 2003 [3].
• The effectiveness of the homoeopathic remedy Gripp-Heel was compared with that of conventional treatments in a prospective, observational cohort study in 485 patients with mild viral infections and symptoms such as fever, headache, muscle pain, cough or sore throat [4].
• Furthermore, these cell lines, especially A.t. GRIP-1, were more sensitive than the Aedes aegypti (L.) (ATC 10) cell line for detection of small amounts of delta-endotoxin of Bacillus thuringiensis serovar. israelensis (de Barjac) [5].

Psychiatry related information on LGALS12

• A group of children (primarily learning disabled) was divided into analysis (n = 488) and cross-validation (n = 400) samples and the following measures were taken for both the LH and the RH Tactile Perception, Finger Agnosia, Fingertip Number Writing, Tactile Form Recognition, Finger Tapping, Grip Strength, Grooved Pegboard, and Mazes [6].

High impact information on LGALS12

• Here we report on the identification of a galectin-like molecule, galectin-12, in a human adipose tissue cDNA library [7].
• Cell cycle regulation by galectin-12, a new member of the galectin superfamily [8].
• Immunocytochemical analysis revealed that galectin-12 was localized in the nucleus of adipocytes, and transfection with galectin-12 cDNA induced apoptosis of COS-1 cells [7].
• Caloric restriction and treatment of obese animals with troglitazone increased galectin-12 mRNA levels and decreased the average size of the cells in adipose tissue [7].
• The induction of galectin-12 expression by the thiazolidinedione, troglitazone, was paralleled by an increase in the number of apoptotic cells in adipose tissue [7].

Biological context of LGALS12

• Ectopic expression of galectin-12 in cancer cells causes cell cycle arrest at the G(1) phase and cell growth suppression [8].
• We conclude that galectin-12 is a novel regulator of cellular homeostasis [8].
• However, GRIP-1 does not compete with AF3 but rather acts to synergize these two transactivation domains [9].
• RESULTS: Grip strength declined in all groups, and lower extremity range of motion showed limited but statistically significant changes [10].
• These findings imply a role for galectin-12 in the pathogenesis of insulin resistance [11].

Anatomical context of LGALS12

• Galectin-12 mRNA was predominantly expressed in adipose tissue of human and mouse and in differentiated 3T3-L1 adipocytes [7].
• Galectin-12 mRNA is sparingly expressed or undetectable in many tissues and cell lines tested, but it is up-regulated in cells synchronized at the G(1) phase or the G(1)/S boundary of the cell cycle [8].
• RESULTS: Treatment of 3T3-L1 cells for 16 h with 10 micromol/l isoproterenol, 100 nmol/l insulin, 0.6 nmol/l tumor necrosis factor alpha (TNFalpha), and 100 nmol/l dexamethasone reduced galectin-12 gene expression between 47% and 85% [11].
• Upper limb impairment was assessed by bilateral power handgrip using the MIE Digital Grip Analyser, goniometry measures of bilateral metacarpophalangeal (MCP) joint ulnar deviation and bilateral active motion of the wrist [12].
• BACKGROUND: Grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality [13].

Associations of LGALS12 with chemical compounds

• Negative regulation of adipose-expressed galectin-12 by isoproterenol, tumor necrosis factor alpha, insulin and dexamethasone [11].
• METHODS: Coated split crimpable hooks (Never-Slip Grip, TP Orthodontics, LaPorte, Ind), ribbed crimpable hooks (TP Orthodontics), and .032-in brass soldered hooks/notched electrodes (Ormco/Sybron Dental Specialties, Orange, Calif) were attached to a 0.019 x 0.025-in stainless steel archwire [14].
• Development of Hand Function and Precision Grip Control in Individuals With Cerebral Palsy: A 13-Year Follow-up Study [15].

Analytical, diagnostic and therapeutic context of LGALS12

• RESULTS: Grip strength improved by 25% in the JPE group (right hand, P < 0.0001; left hand, P = 0.0005), but not in the control group [16].
• The outcome of trochanteric reattachment in revision total hip arthroplasty with a Cable Grip System: mean 6-year follow-up [17].
• METHODS: Grip strength (n = 986) and appendicular muscle mass (n = 328, using dual-energy x-ray absorptiometry) were obtained in 1995 and 1996 and repeated after a 3-year follow-up [18].
• MATERIALS AND METHODS: Samples were collected from saliva and maxillary dentures of 12 patients who wore existing dentures without adhesives for 2 weeks, then wore dentures with adhesive (Poly Grip Free; Glaxo Smith Kline, U.K.) for 2 weeks [19].

References